| 研究課題/領域番号 |
17F17093
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| 研究機関 | 京都大学 |
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研究代表者 |
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| 研究分担者 |
DUBOSCQ JULIE 京都大学, 霊長類研究所, 外国人特別研究員
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| 研究期間 (年度) |
2017-10-13 – 2020-03-31
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| キーワード | social transmission / simian foamy virus / macaque / strain genetic profile |
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| 研究実績の概要 |
The aim of the research is to foster a better understanding of pathogen transmission in social animals. The study of pathogens expressing enough genetic diversity that different strains can be identified helps tracking transmission characteristics, e.g. simian foamy virus (SFV) and E. coli. Strain genetic profile is then linked to individual social profile: individuals more frequently in contact with each other should share more similar strains than others. The fellow collected data on two groups of two species of socially-housed captive macaques at the PRI. Early analyses show that young macaques seem not infected by SFV before reaching 2 yo. Strain sharing within a dyad seems related to similarity in age and to grooming frequency, indicating horizontal or oblique transmission.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
This project is a development of a previous study conducted at PRI with the same host and collaborators so its feasibility was assessed as high. Unfortunately, several issues impeded significant progress: 1/ whole-group sampling of saliva, necessary to get virus genetic material, from the socially-housed captive groups where behavioral observation was also conducted did not take place in fall 2017. Only a limited number of monkeys have been re-sampled this year; 2/ virus genetic profiling turned out to be efficient and specific only for Japanese macaques, not for Rhesus macaques, so molecular analyses have stalled; 3/ The fellow became pregnant, which prevented some types of lab work, again slowing down progress.
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| 今後の研究の推進方策 |
The major activities in 2018 were planned as 1/ behavioural observations, 2/ DNA/RNA extraction, genotyping and sequencing and 3/ analysis of these data together. The end of the year was to be devoted to another saliva sampling during the annual health check. The plan was also to participate in an international conference to present this work. Major costs should have concerned consumables and travels.
This plan is postponed as I will be on maternity leave from June 26th until spring next year. In the meantime, the fellow is analysing the data already collected and supervising student projects on related topics.
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