| 研究実績の概要 |
Our mechanistic understanding of gastric cancer remains limited, hampering the development of more effective therapeutics.
Using proprietary new mouse models and ex vivo culture assays, we will i) evaluate the contribution of Lgr5-expressing corpus stem cells to inflammation-driven cancer initiation ii) generate the first inflammation driven mouse models of metastatic gastric cancer to functionally evaluate Lgr5-expressing tumor cells as cancer stem cells iii) evaluate the contribution of TCGA derived driver mutations such as RhoA and RNF43 to in vivo gastric cancer formation.
These research avenues will deliver invaluable mechanistic insight into gastric cancer progression and will reveal novel opportunities for therapeutic intervention.
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