| 研究実績の概要 |
We developed introductory model of dual pathway between sinoatrial and atrioventricular nodes in Matlab/Simulink; environment incorporated into our heterogeneous oscillator cardiac conduction model. The dial pathway model is based on Aliev-Panfilov type nonlinear differential equation.
The model demonstrated its capability to reproduce different AV dual pathway conduction phenomena without changing the model’s parameters and number of its units, such as normal fast and slow pathways behavior, AV node pacemaking, AV node reentry, S1-S2 excitation propagation decay.
We also developed computer code for extended heterogeneous oscillator model of cardiac conduction system for generation of realistic 12 lead ECG waveforms, which includes artificial RR-tachogram with the specific statistics of heart rate, the frequency-domain characteristics of heart rate variability (HRV) produced by Mayer and respiratory sinus arrhythmia waves, normally distributed additive noise and a baseline wander that couple the respiratory frequency. Pertinent research paper and open source Matlab/Simulink code were published.
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| 今後の研究の推進方策 |
We are going to tune the dual pathway model parameters to obtain atrioventricular node slow and fast pathways conduction velocities and other properties corresponding to human heart.
Next, we will apply the developed model to simulate well-known clinical cases, such as bundle branch blocks, WPW syndrome.
We also are going to begin initial development of cardiac conduction system model reproducing intracardiac potentials which could be used for ICD testing, similar to recent works by Oxford University and Auckland University groups.
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