| 研究課題/領域番号 |
17K09666
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| 研究機関 | 慶應義塾大学 |
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研究代表者 |
ヒガブ中井 アハマド 慶應義塾大学, 医学部(信濃町), 特任講師 (00507915)
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| 研究期間 (年度) |
2017-04-01 – 2020-03-31
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| キーワード | lung stem cells / rachea stem cells / calorie restriction / aging |
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| 研究実績の概要 |
We have identified the effect of aging on lung tissue stem cells. We found that aging reduced number of basal stem cells in the trachea. We have achieved a successful calorie restriction protocol that caused both young and old mice to lose weight. We found that calorie restriction increased the number of basal stem cells in the trachea both in young and old mice.
We successfully created a 3D cell culture technique that could mimic the in vivo calorie restriction.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The calorie restriction protocol went successfully so we did not need to repeat it several times to adjust.
Samples collected showed clear statistical significance.
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| 今後の研究の推進方策 |
We will examine the roles played by Sirt and mTOR genes, that are known to be related to calorie management. We will verify their roles in animal samples and in 3D culture system.
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| 次年度使用額が生じた理由 |
ほとんど残っていません。
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