研究課題
The targets in proposed plan have been well fulfilled specified as following:1. A low-attachment substrates have been designed and optimized to create cardiac tissue ring with spontaneous traveling wave. 2. The cardiomyocytes trained by traveling wave demonstrated matured sarcomere structure, up-regulated gene expression, improved calcium handling properties and mitochondrial function. 3. A systems compatible to 24-well cell culture dish have been created for up scaled production of ring. 4. One Japanese patent has been submitted. “Circulating traveling waves enhance the maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring” has been sent out for review in Science Advance. Two other papers supported by the grant have been also published.
すべて 2019 2018 その他
すべて 国際共同研究 (1件) 雑誌論文 (2件) (うち国際共著 2件、 査読あり 2件、 オープンアクセス 1件) 学会発表 (1件) 産業財産権 (1件)
Advanced Healthcare Materials
巻: In press ページ: In press
Stem Cell Reports
巻: 11 ページ: 142-156
https://doi.org/10.1016/j.stemcr.2018.06.003
