| 研究実績の概要 |
In a large-scale prospective birth cohort, we investigated the association of early life allergic conditions (wheeze, rhinoconjunctivitis, and eczema) with overweight/obesity risk in children at age 7. Also, we assessed the association of 3 urinary inflammatory biomarkers including 8-hydroxy-2 deoxyguanosine (8-OHdG), hexanoyl-lysin (HEL), and 4-hydroxynonenal (4-HNE) with the risk of allergic diseases at age 7 (n=568) and 10 years (n=428). With a longitudinal analysis, we found the prevalence of rhinoconjunctivitis (3.3 to 21.2%) and eczema (11.3% to 22.4%) significantly increased from early life to age 10. The prevalence of wheeze peaked at 4 years of age (21.6%) with a consequent decline at age 7 (13.3%) and 10 (9.2%). Among children aged 10, 41.5% had at least of the allergic diseases, 46.0% had FeNO >20 parts per billion (p.p.b), and 38.5% had blood eosinophil number >300/µl. At age 10, 70.5% and 22.3% of children were sensitized to inhaled and food allergens, respectively. Wheeze at age 0-2, 4 and 7 years of age was significantly associated with the risk of overweight/obesity at age 7. In contrast, rhinoconjunctivitis and eczema did not show any significant associations with the risk of overweight/obesity at age 7. Among examined urinary biomarkers, HEL had higher levels among children with wheeze at age 7. Currently, I am examining the association of urinary biomarkers and the development of allergic diseases at age 10. Among adult asthma patients, we found the association of abdominal visceral fat with urinary HEL and HNE biomarkers (n=206).
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