| 研究実績の概要 |
We have conducted trainings to research nurses for data collection, data entry, and management in the hospital. One lab technician has been trained for specimen storage, lab data management and DNA extraction. We have installed a deep freezer (-40°C) in the lab.
We had meetings with the local collaborators (Doctors in the hospital and members of Nepal Paediatric Society) on the research site as well as online in Polycom. We decided to modify the research plan so as to get ethical approval from the Ethical Review Board of Nepal Health Research Council. We planned for the assessment of the impact of PCV-10 vaccine on bacterial load and multiple serotypes on children at the age of 6, and 10 weeks and 9 months when they come for PCV-10 vaccination in the hospital.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Meetings with the local collaborators, training to the research nurses and lab technician in the hospital have been finished. Preparation of the lab for the specimen storage is completed.
Now, we need to apply for the Nepal Health Research Council for the ethical clearance to start the research project, along with the ethical clearance in the School of Tropical Medicine and Global Health, Nagasaki University. It took some time as we had to modify the original research plan, which needed to have many meetings.
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| 今後の研究の推進方策 |
The followings are the plan to carryout the research:
* May-July, 2018: Ethical clearance in TMGH and Nepal Health Research Council, along with preparation of questionnaire in Epi Info, informed consent forms, Standard Operating Procedures for nasopharyngeal sample taking and storage.
*Aug, 2018-April, 2019: Enrollment of children, data and sample collection. The research progress will be monitored every month by checking the number of enrolments of children, completion of necessary documents, follow up of SOPs by the nurses and lab technician.
*May-Sep, 2019: Sample processing (DNA extraction, and serotyping and bacterial load determination) and data cleaning.
*Oct 2019-Mar 2020: Data-analysis, manuscript preparation and publication.
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