| 研究実績の概要 |
We found that bilateral electrical stimulation of the ACC on MIT gradually reduced MIT. Next, the bilateral ACC of Thy1-channelrhodopsin2(ChR2)-EFYP mouse, in which deep layer pyramidal neurons express ChR2, was optogenetically activated. Optical stimulation (5 ms pulses at 50 Hz for 60 s duration) consistently increased bladder pressure with the latency and the peak time of 6.7 s and 30.2 s after the stimulation, respectively (N=3 mice).
These results indicate that activation of the ACC outputs induces micturition.
Our results demonstrated the novel role of the ACC in the regulation of micturition; the ACC is not only involved in the filling phase but also in the voiding phase. Further selective manipulation of neuronal activity in the ACC may precisely regulate micturition process.
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