Elucidation of the functions of Ywhag and Ywhae in bone development using their knockout mice

2018 年度 研究成果報告書

• 研究課題/領域番号: 17K17094
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 機能系基礎歯科学
• 研究機関: 長崎大学
• 研究代表者: 姜 晴 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (00790007)
• 研究期間 (年度): 2017-04-01 – 2019-03-31
• キーワード: 骨代謝学

研究成果の概要

Wild-type and Ywhag-/-, Ywhae-/- and Ywhae+/- samples were collected at E15.5, E18.5, 3 weeks and 8 weeks of age. Ywhae-/- embryos showed mild dwarfism, body weight and bone volume of Ywhag-/- mice and Ywhae+/- mice were lower than that of wild-type mice.

自由記述の分野

医歯薬学

研究成果の学術的意義や社会的意義

Elucidation of the molecular mechanisms of 14-3-3s will hopefully provide novel insights into the therapy of many diseases, such as osteoporosis, and is useful for new drugs development for osteoporosis and bone regeneration.