| 研究実績の概要 |
2019年は、研究「日本で行われた抗うつ剤のプラセボ対象臨床試験8本、約4000人分の個人データを元に、IPD-MAを実施する」について3本の原著論文（Maruo K, et al (in press) Qualitative treatment-subgroup interactions in the antidepressant treatment of major depression: Application of QUINT to individual participant data from seven placebo-controlled randomized controlled trials. Personalized Medicine in Psychiatry.; Shinohara K, et al (2019) Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data. Evidence-Based Mental Health, 22, 10-16.; Noma H, et al (2019) Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials. Journal of Affective Disorders, 250, 419-424.)を、研究「上記の具体例を通じ、IPD-MAおよびIPD-NMAにおける統計学的方法を検証・解決する」について3本の原著論文(Noma H, et al (2019) Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models. BMC Medical Research Methodology, 19, 33.; Noma H, et al (in press) Permutation inference methods for multivariate meta-analysis. Biometrics.; Nagashima K, et al (2019) Prediction intervals for random-effects meta-analysis: A confidence distribution approach. Statistical Methods in Medical Research, 28, 1689-1702.)
を発表した。
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