がんの骨転移に対する包括的分子生物学治療

2008 年度 研究成果報告書

• 研究課題/領域番号: 18390412
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 整形外科学
• 研究機関: 三重大学
• 研究代表者: 内田 淳正 三重大学, 大学院・医学系研究科, 教授 (40176681)
• 研究分担者: 楠崎 克之 三重大学, 医学部・附属病院, 診療等従事者 (30177993) ; 松峯 昭彦 三重大学, 医学部・附属病院, 講師 (00335118) ; 明田 浩司 三重大学, 医学部・附属病院, 助教 (20422826)
• 研究期間 (年度): 2006 – 2008
• キーワード: 転移性骨腫瘍 / 温熱療法 / 光線力学療法 / 磁性体 / アクリジンオレンジ

研究概要

四肢や骨盤部および肩甲帯に発生する転移性骨腫瘍に対して低侵襲で有効性の高い治療法の開発は進行期の癌患者のQOLを高めるのに重要である。そのため、磁性体温熱療法およびアクリジン光線力学療法の有効性を検討した。その結果、腫瘍局所制御の効果は長期間維持されていた。患者の活動性はADL評価で著しい向上がみられた。治療後の副作用を全く認めない点に置いて放射線治療群より有用と考えられた。

研究成果

• [雑誌論文] A new therapeutic modality involvingacridine orange excitation by photonenergy used during reduction surgeryfor rhabdomyosarcomas (2008)
  • 著者名/発表者名: Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shintani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Uchida A
  • 雑誌名: Oncol Rep 21 ページ: 89-94
• [雑誌論文] Differentiation betweenneurofibromas and malignantperipheral nerve sheath tumors inneurofibromatosis 1 evaluated by MRIa (2008)
  • 著者名/発表者名: Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Niimi R, Matsubara T, Uchida K, Murata T, Kudawara I, UedaT, Naka N, Araki N, Maeda M, Uchida A
  • 雑誌名: J Cancer Res Clin Oncol (Epub aheadof print)
• [雑誌論文] Usefulness of limb salvage surgery forbone and soft tissue sarcomas of thedistal lower leg (2008)
  • 著者名/発表者名: Niimi R, Matsumine A, Kusuzaki K,Kuratsu S, Araki N, Aoki Y, Ueda T,Kudawara I, Myoui A, Ieguchi M,Hashimoto N, Yoshikawa H, Uchida A
  • 雑誌名: J Cancer Res ClinOncolc 134 ページ: 1087-95
• [雑誌論文] Flash wave light strongly enhanced thecytocidal effect of photodynamictherapy with acridine orange on amouse osteosarcoma cell line (2007)
  • 著者名/発表者名: Satonaka H, Kusuzaki K, Matsubara T,Shintani K, Wakabayashi T, Nakamura T,Matsumine A, Uchida A
  • 雑誌名: Anticancer Res 27 ページ: 3339-44
• [雑誌論文] Novel hyperthermia for metastaticbone tumors with magnetic materials bygenerating an alternatingelectromagnetic field (2007)
  • 著者名/発表者名: Matsumine A, Kusuzaki K, Matsubara T, Shintani K, Satonaka H, Wakabayashi T, Miyazaki S, Morita K, Takegami K,Uchida A
  • 雑誌名: Clin ExpMetastasis 24 ページ: 191-200
• [雑誌論文] Expression of hypoxia-induciblefactor (HIF)-1alpha as a biomarker ofoutcome in soft-tissue sarcomas (2006)
  • 著者名/発表者名: Shintani K, Matsumine A, Kusuzaki K,Matsubara T, Satonaka H, WakabayashiT, Hoki Y, Uchida A
  • 雑誌名: Virchows Arch 449 ページ: 673-81
• [雑誌論文] Calcium phosphate cement in musculoskeletal tumor surgery (2006)
  • 著者名/発表者名: Matsumine A, Kusuzaki K, Matsubara T, Okamura A, Okuyama N, Myyazaki S, Shintani K, Uchida A
  • 雑誌名: J Surg Oncol 93 ページ: 212-220
• [雑誌論文] Low-dose methotrexate inhibits lungmetastasis and lengthens survival inrat osteosarcomae (2006)
  • 著者名/発表者名: Tomoda R, Seto M, Hioki Y, Sonoda J,Matsumine A, Kusuzaki K, Uchida A
  • 雑誌名: Clin Exp Metastasis 22 ページ: 559-564
• [雑誌論文] Acridine orange used for photodynamic therapy accumulates in malignant musculoskeletal tumors depending on pHgradient (2006)
  • 著者名/発表者名: Matsubara T, Kusuzaki K, MatsumineA, Shintani K, Satonaka H, Uchida A
  • 雑誌名: Anticancer Res 26 ページ: 187-194
• [雑誌論文] Lung radiofrequency ablation inpatients with pulmonary metastasesfrom musculoskeletal sarcomas : Aninitial experience
  • 著者名/発表者名: Nakamura T, Matsumine A, Yamakado K, Nakazora S, Kusuzaki K, Matsubara T,Takaki H, Nakatsuka A, Takeda K , Abo D, Shimizu T, Uchida A
  • 雑誌名: Cancer (in press)
• [学会発表] A new Limb Salvage Surgery in Cases ofHigh-Grade Soft Tissue Sarcoma usingPhotodynamic Surgery, followed byPhoto- and Radiodynamic Therapy withAcridine Orange (2008)
  • 著者名/発表者名: Nakamura T, Kusuzaki K, Niimi R,Nakazora S, Matsubara T, Matsumine A,Murata H, Uchida A
  • 学会等名: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • 年月日: 20080926-28
• [学会発表] In Vivo Antitumor Effect Of Photodynamic Therapy With AcridineOrange Using Flash Wave Light On MouseOsteosarcoma (2008)
  • 著者名/発表者名: Satonaka H, Kusuzaki K, Matsubara T,Shintani K, Wakabayashi T, NakamuraT, Matsumine A, Uchida A
  • 学会等名: 7th Asia Pacific Musculoskeletal Tumor Society Meeting
  • 年月日: 20080926-28
• [学会発表] Limb Salvage Surgery for Bone And SoftTissue of The Distal Lower Leg7th (2008)
  • 著者名/発表者名: Niimi R, Matsumine A, Kusuzaki K,Nakamura T, Nakazora S, Kuratsu N.Araki Y, Aoki T, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N ,Yoshikawa H , Uchida A
  • 学会等名: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • 年月日: 20080926-28
• [学会発表] Novel Hyperthermia for MetastaticBone Tumors with Magnetic Materials (2008)
  • 著者名/発表者名: Matsumine A, Kusuzaki K, Nakamura T,Niimi R, Nakazora S, Matsubara T,Satonaka H, Uchida A
  • 学会等名: 7th. Asia Pacific MusculoskeletalTumor Society Meeting
  • 年月日: 20080926-28
• [学会発表] Total Femoral Replacement afterResection of Malignant Musculoskeletal Tumors (2008)
  • 著者名/発表者名: Nakazora S, Matsumine A, Nakamura T,Niimi R, Kusuzaki K, Uchida A
  • 学会等名: 7th. Asia Pacific MusculoskeletalTumor Society Meeting
  • 年月日: 20080926-28
• [学会発表] Transfection of Naked NF kappa B DecoyOligodeoxynucleotide SuppressesPulmonary Metastasis by MurineOsteosarcoma in theAlginate-encapsulated Tumor Spheroid Model (2008)
  • 著者名/発表者名: Nishimura A, Akeda A, Matsubara T,Kusuzaki K, Matsumine A, Kasai K,Gemba T, Uchida A
  • 学会等名: 54th Annual Meeting of the OrthopaedicResearch Society
  • 年月日: 20080302-05
• [学会発表] Injection of Naked DecoyOligodeoxynucleotide against Nuclear Factorkappa B into a MurineOsteosarcoma in a SpontaneousPulmonary Metastasis Mode (2008)
  • 著者名/発表者名: Matsubara T, Akeda K, Nishimura A,Kusuzaki K, Matsumine A, Shintani K,Satonaka H, Kasai Y, Gemba T, Uchida A
  • 学会等名: 54th Annual Meeting of the OrthopaedicResearch Society
  • 年月日: 20080302-05
• [学会発表] Novel hyperthermia for metastasisbone tumors with magnetic materials bygenerating an alternatingelectromagnetic field 14th (2007)
  • 著者名/発表者名: Matsumine A, Kusuzaki K, Matsubara T, Morita K, Takegami K, Uchida A
  • 学会等名: International Symposium on Limb Salvage
  • 年月日: 20070911-14
• [学会発表] Calcium Phosphate Cement InMusculoskeletal Tumor Surgery (2006)
  • 著者名/発表者名: Matsumine A, Kusuzaki K, Matsubara T, Okamura A, Okuyama N, Miyazaki S, Shintani K, Uchida A
  • 学会等名: 58th Annual International Congress of the Egyptian Orthopaedic Association
  • 発表場所: Cairo
  • 年月日: 20061200
• [学会発表] Prevention of bone metastasis by thethrombin inhibitor (2006)
  • 著者名/発表者名: Asanuma K, Yoshikawa T, WakabayashiH, Hayashi T, Matsumine A, KusuzakiK, Suzuki K, Uchida A
  • 学会等名: 52th Annual Meeting of the Orthopaedic Research Society
  • 発表場所: Chicago
  • 年月日: 20060300