冠動脈MRAと心筋パーフュージョンMRI定量解析による冠動脈疾患の総合的評価

2008 年度 研究成果報告書

• 研究課題/領域番号: 18591340
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 放射線科学
• 研究機関: 三重大学
• 研究代表者: 佐久間 肇 三重大学, 医学部附属病院, 准教授 (60205797)
• 研究分担者: 竹田 寛 三重大学, 大学院・医学系研究科, 教授 (70106988)
• 連携研究者: 加藤 憲幸 三重大学, 大学院・医学系研究科, 准教授 (40214390) ; 須澤 尚久 三重大学, 医学部附属病院, 医員 (80378372)
• 研究期間 (年度): 2006 – 2008
• キーワード: MRI / 冠動脈疾患 / 心筋血流 / 冠動脈MRA / 狭心症 / 心筋梗塞

研究概要

冠動脈MRAと心筋パーフュージョンMRI定量解析による冠動脈疾患の総合的評価を行った。MRIによる心筋血流量(ml/min/g)はアンモニア心筋血流PET による結果とよく一致し、負荷心筋パーフュージョンMRI の有意冠動脈狭窄診断感度は89%、特異度は91%であった。冠動脈MRA は放射線被曝を伴わない非侵襲的な冠動脈評価を可能とし、その診断感度は92%、特異度は90%と高かった。冠動脈MRAと心筋パーフュージョンMRI を実施することは、冠動脈病変の鋭敏な検出と、虚血の有無に基づく的確な冠動脈インターベンションの適応決定に役立つ。

研究成果

• [雑誌論文] Quantitative analysis of first-pass contrast-enhanced myocardial perfusion MRI using a patlak plot method and blood saturation correction (2009)
  • 著者名/発表者名: Ichihara T, Ishida M, Kitagawa K, Ichikawa Y, Natsume T, Yamaki N, Maeda H, Takeda K, Sakuma H.
  • 雑誌名: Magn Reson Med (Epub ahead of print)
• [雑誌論文] Tanigawa T, Kitamura T, Takeda K, Ito M. Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire (2009)
  • 著者名/発表者名: Kurita T, Sakuma H, Onishi K, Ishida M, Kitagawa K, Yamanaka T, Tanigawa T, Kitamura T, Takeda K, Ito M.
  • 雑誌名: Eur Heart J. 30 ページ: 444-452
• [雑誌論文] Absolute blood contrast concentration and blood signal saturation on myocardial perfusion MRI : estimation from CT data (2009)
  • 著者名/発表者名: Ishida M, Sakuma H, Murashima S, Nishida J, Senga M, Kobayasi S, Takeda K, Kato N.
  • 雑誌名: J Magn Reson Imaging 29 ページ: 205-210
• [雑誌論文] Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : a multicenter study (2008)
  • 著者名/発表者名: Kitagawa K, Sakuma H, Nagata M, Okuda S, Hirano M, Tanimoto A, Matsusako M, Lima JA, Kuribayashi S, Takeda K.
  • 雑誌名: Eur Radiol 18 ページ: 2808-2816
• [雑誌論文] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging (2008)
  • 著者名/発表者名: Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H.
  • 雑誌名: Circ J. 72 ページ: 378-383
• [雑誌論文] Magnetic resonance imaging for ischemic heart disease (2007)
  • 著者名/発表者名: Sakuma H.
  • 雑誌名: J Magn Reson Imaging 26 ページ: 3-13
• [雑誌論文] Diagnostic value of late gadolinium-enhanced MRI and first-pass dynamic MRI for predicting functional recovery in patients after acute myocardial infarction (2007)
  • 著者名/発表者名: Kitagawa K, Ichikawa Y, Hirano T, Makino K, Kobayashi S, Takeda K, Sakuma H.
  • 雑誌名: Radiat Med 25 ページ: 263-271
• [雑誌論文] Detection of coronary artery stenosis with whole-heart coronary magnetic resonance angiography (2006)
  • 著者名/発表者名: Sakuma H, Ichikawa Y, Chino S, Hirano T, Makino K, Takeda K.
  • 雑誌名: J Am Coll Cardiol 48 ページ: 1946-1950
• [学会発表] Quantification of Rest and Stress Myocardial Blood Flow with Prospectively Gated Dynamic Multi-slice CT : Comparison with 13N-ammonium Myocardial Perfusion PET (2008)
  • 著者名/発表者名: Ishida M, Sakuma H, Nagata M, Ishida N, Ichihara T, Nakajima H, Ito M, Takeda K.
  • 学会等名: 93th RSNA
  • 発表場所: Chicago
  • 年月日: 20081130-1205
• [学会発表] Whole heart coronary magnetic resonance angiography acquired with 32-channel cardiac coils and high parallel imaging factor (2008)
  • 著者名/発表者名: Nagata M, Sakuma H, Ishida N, Ishida M, Nakajima H, Ito M, Takeda K.
  • 学会等名: 93th RSNA
  • 発表場所: Chicago
  • 年月日: 20081130-1205
• [学会発表] Subendmyocardial Perfusion Reserve Correlated with Left Ventricular Diastolic Function in Patients with Various Types of Left Ventricular Hypertrophy (2008)
  • 著者名/発表者名: Kurita T, Onishi K, Sakuma H, Takamura T, Nagata M, Nakajima H, Ishida M, Fujimoto N, Dohi K, Takeda K, Ito M.
  • 学会等名: AHA scientific sessions 2008
  • 発表場所: New Orleans
  • 年月日: 20081109-11
• [学会発表] Coronary Artery Evaluation Using Magnetic Resonance Angiography : A Multicenter study (2008)
  • 著者名/発表者名: Kato S, Sakuma H, Ishida M, Nagata M, Ishida M, Ichikawa Y, Katahira K, Matsumoto Y, Seo K, Ochiai R, Kobayashi Y.
  • 学会等名: AHA scientific sessions 2008
  • 発表場所: New Orleans
  • 年月日: 20081109-11
• [学会発表] Adenosine-stress CT Myocardial Perfusion Imaging : Comparison with Stress Myocardial Perfusion MRI in Patients with Coronary Artery Disease (2008)
  • 著者名/発表者名: Ishida M, Sakuma H, Kato S, Nagata M, Ishida N, Nakamura M, Nakajima H, Ito M, Takeda K
  • 学会等名: AHA scientific sessions 2008
  • 発表場所: New Orleans
  • 年月日: 20081109-11
• [学会発表] Absolute quantification of myocardial blood flow from rest perfusion MRI can provide improved sensitivity for predicting myocardial viability in patients early after myocardial infarction (2008)
  • 著者名/発表者名: Nagata M, Sakuma H, Kurita T, Ishida N, Ishida M, Mikami Y, Nakajima H, Ito M, Takeda K
  • 学会等名: ECR
  • 発表場所: Vienna, Austria
  • 年月日: 20080306-10
• [学会発表] Rest and stress myocardial blood flow (MBF) measured by fully quantitative analysis of first-pass perfusion MRI showed good agreement with rest and stress MBF by radio-water PET (2007)
  • 著者名/発表者名: Ishida M, Sakuma H, Nagata M,Ishida N, Mikami Y, Ichihara T, Maeda H,Goko Y, Parkka J, Kunuuti J, Haltiala J, Takeda K
  • 学会等名: 92th RSNA
  • 発表場所: Chicago
  • 年月日: 20071126-1201
• [学会発表] Long Term Prognostic Value of Stress Perfusion CMR and Late Gadolinium Enhanced CMR for The Prediction of Major Adverse Cardiac Events (2007)
  • 著者名/発表者名: Kurita T, Sakuma H, Onishi K, Nagata M, Takamura T, Ishida M, Fujimoto N, Dohi k, Takeda K, Ito M.
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
  • 年月日: 20071104-07
• [学会発表] Absolute Quantification of Rest Myocardial Blood Flow by Cardiac Magnetic Resonance can provide Improved Prediction of Functional Recovery in Patients with Acute Myocardial Infarction (2007)
  • 著者名/発表者名: Kurita T, Sakuma H, Nagata M, Ishida M, Tanigawa T, Onishi K, Isaka N, Takeda K, Ito M.
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
  • 年月日: 20071104-07
• [学会発表] Myocardial Perfusion Reserve Determined by Model Based Quantitative Analysis of Stress-Rest Perfusion MRI Permits Improved Accuracy in Predicting Coronary Artery Diseases When Compared with Semiquantitative Analysis (2007)
  • 著者名/発表者名: Ishida M, Sakuma H, Shi Y, Nagata M, Ishida N, Mikami Y, Ichihara T, Maeda H, Goko Y, Kurita T, Ito M, Takeda K.
  • 学会等名: AHA scientific sessions2007
  • 発表場所: Orlando
  • 年月日: 20071104-07
• [学会発表] Comparison between Radio-water PET and Model Based Quantitative Analysis of Myocardial Perfusion Magnetic Resonance (2007)
  • 著者名/発表者名: Ishida M, Parkka JP, Sakuma H, Nagata M, Ishida N, Mikami Y, Ichihara T, Takeda K, Maeda H, Goko Y, Kunuuti J, Hartiala JJ
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
  • 年月日: 20071104-07
• [学会発表] Absolute quantification of myocardial blood flow in patients with acute myocardial infarction after successful percutaneous coronary interventions (2007)
  • 著者名/発表者名: Nagata M, Sakuma H, Ishida M, Kurita T, Ishida N, Tanigawa T, Onishi K, Ichihara T, Ito M, Takeda K
  • 学会等名: 15th ISMRM
  • 発表場所: Berlin
  • 年月日: 20070520-25
• [学会発表] Absolute Quantification of Myocardial Blood Flow Using First-Pass Perfusion MRI : Extraction Fraction of Gd-DTPA Varies with Myocardial Blood Flow in Human Myocardium (2007)
  • 著者名/発表者名: Ishida M, Sakuma H, Ichihara T, Goko Y, Ishida N, Nagata M, Kitagawa K, Maeda H, Kurita T, Teraoka K, Takeda K
  • 学会等名: 15th ISMRM
  • 発表場所: Berlin
  • 年月日: 20070520-25
• [学会発表] MR quantification of altered subebdocardia myocardial blood flow in patients with diastolic heart failure (2006)
  • 著者名/発表者名: Kurita T, Onishi K, Sakuma H, Ishida N, Fujimoto N, Dohi K, Ito M, Takeda K.
  • 学会等名: AHA
  • 発表場所: American Heart Association in Chicago
  • 年月日: 20061112-15
• [学会発表] Regional Myocardial Perfusion Reserve Determined by Patlak Analysis of Myocardial Perfusion MRI Showed a Good Correlation with Coronary Flow Velocity Reserve Measured by Doppler Flow Wire (2006)
  • 著者名/発表者名: Kurita T, Kitagawa K, Onishi K, Takeda k, Nakano T, Sakuma H.
  • 学会等名: ISMRM : International society of magnetic resonance in medicine (Scientific conference)
  • 発表場所: Seattle, USA
  • 年月日: 20060508-12