膝レントゲンデジタル処理による変形性関節症の重症度定量システムの確立

2008 年度 研究成果報告書

• 研究課題/領域番号: 18689031
• 研究種目: 若手研究(A)
• 配分区分: 補助金
• 研究分野: 放射線科学
• 研究機関: 東京大学
• 研究代表者: 岡 敬之 東京大学, 医学部附属病院, 特任助教 (60401064)
• 研究期間 (年度): 2006 – 2008
• キーワード: 画像診断学(含放射線診断学、核医学)

研究概要

現在、変形性関節症(osteoarthritis:OA)のX線画像評価基準として、カテゴリカルな評価法であるKellgren-Lawrenceグレードが広く用いられているが、読影者の主観で評価が異なり、微細な変化を検出することができない。このため、X線画像を一定の基準で自動的に評価できるソフトウエアの開発を行った。本システムは、関節裂隙・骨棘などの6項目について計測し、OAの診断に際して客観的な数値を表すことができるため、評価基準の明確化に寄与するものと考えている。

研究成果

• [雑誌論文] Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features (2009)
  • 著者名/発表者名: Shoda N, Seichi A, Takeshita K, Chikuda H, Ono T, Oka H, Kawaguchi H, Nakamura K
  • 雑誌名: Eur Spine J (in press)
  • 査読あり
• [雑誌論文] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts: the ROAD study (2009)
  • 著者名/発表者名: Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Ann Rheum Dis (in press)
  • 査読あり
• [雑誌論文] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis, or vice-versa?: The Miyama Study (2009)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kinoshita H, Yoshida M, Mabuchi A, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: Osteoporos Int (in press)
  • 査読あり
• [雑誌論文] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in the elderly of population-based cohorts: the ROAD study (2009)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Arthritis Care & Research (in press)
  • 査読あり
• [雑誌論文] Prevalence of knee osteoarthritis, lumbar spondylosis and osteoporosis in Japanese men and women: The Research on Osteoarthritis/osteoporosis Against Disability (ROAD) (2009)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: J Bone Miner Metab (in press)
  • 査読あり
• [雑誌論文] アジア諸国における脊椎椎体骨折有病率の比較:The Asian Vertebral Osteoporosis Study (AVOS) (2009)
  • 著者名/発表者名: 吉村典子, 阿久根徹, 村木重之, 岡敬之, 川口浩, 中村耕三, Edith MC Lau, Anthony Kwok, Ping-chung Leung
  • 雑誌名: Osteoporos Jpn 17 (in press)
  • 査読あり
• [雑誌論文] Association between height loss and bone loss, cumulative incidence of vertebral fractures and future QOL: The Miyama Study (2008)
  • 著者名/発表者名: Yoshimura N, Kinoshita H, Oka H, Muraki S, Mabuchi A, Kawaguchi H, Nakamura K, Nakamura T
  • 雑誌名: Osteoporos Int 19 ページ: 21-28
  • 査読あり
• [雑誌論文] Fully automatic quantification of knee osteoarthritis severity on standard radiographs (2008)
  • 著者名/発表者名: Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H
  • 雑誌名: Osteoarthritis and Cartilage 16 ページ: 1300-1306
  • 査読あり
• [雑誌論文] 骨粗鬆症の発生率と骨代謝マーカー、内因性ホルモンとの関連:漁村コホート10年間の追跡 (2008)
  • 著者名/発表者名: 吉村典子, 岡敬之, 村木重之, 阿久根徹, 馬淵昭彦, 川口浩, 中村耕三
  • 雑誌名: Osteoporos Jpn 16 ページ: 40-44
  • 査読あり
• [雑誌論文] コンピュータを用いた大腿骨頸部骨形態自動計測法の開発 (2008)
  • 著者名/発表者名: 村木重之, 阿久根徹, 岡敬之, 吉村典子
  • 雑誌名: Osteoporos Jpn 16 ページ: 644-647
  • 査読あり
• [雑誌論文] Diet and lifestyle associated with increased bone mineral density: cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic (2007)
  • 著者名/発表者名: Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K
  • 雑誌名: J Orthop Sci 12 ページ: 317-320
  • 査読あり
• [雑誌論文] Risk factors for knee osteoarthritis in Japanese men: A case control study (2006)
  • 著者名/発表者名: Yoshimura N, Kinoshita H, Hori N, Nishioka T, Ryujin M, Mantani Y, Miyake M, Takeshita T, Ichinose M, Yoshida M, Oka H, Kawaguchi H, Nakamura K, Cooper C
  • 雑誌名: Modern Rheumatology 16 ページ: 24-29
  • 査読あり
• [雑誌論文] Decreased activities of daily living and associations with bone loss among aged residents in a rural Japanese community: The Miyama Study (2006)
  • 著者名/発表者名: Oka H, Yoshimura N, Kinoshita H, Saika A, Kawaguchi H, Nakamura K
  • 雑誌名: J Bone Miner Metab 24 ページ: 307-313
  • 査読あり
• [雑誌論文] Cumulative Incidence and Changes in Prevalence of Vertebral Fractures in a Rural Japanese Community: A 10-year Follow-up of the Miyama Cohort (2006)
  • 著者名/発表者名: Yoshimura N, Kinoshita H, Oka H, Muraki S, Mabuchi A, Kawaguchi H, Nakamura K
  • 雑誌名: Archives Osteoporos, DOI 10 ページ: 1007/s11657-006-0007-0
  • 査読あり
• [雑誌論文] Prognostic factors for patients with spinal metastases from lung cancer (2006)
  • 著者名/発表者名: Ogihara S, Seichi A, Hozumi T, Oka H, Ieki R, Namamura K, Kondoh T
  • 雑誌名: Journal Article Spine 31(14) ページ: 1585-90
  • 査読あり
• [雑誌論文] Incidence and prognostic factors of Japanese breast cancer patients with bone metastasis (2006)
  • 著者名/発表者名: Oka H, Kondoh T, Seichi A, Hozumi T, Nakamura K
  • 雑誌名: J Orthop Sci. 11 ページ: 13-9
  • 査読あり
• [雑誌論文] 骨粗鬆症と変形性関節症の因果関係に関する研究(報告) (2006)
  • 著者名/発表者名: 吉村典子, 雑賀明宏, 岡敬之
  • 雑誌名: Osteoporos Jpn 14 ページ: 25-29
  • 査読あり
• [学会発表] Association of Radiographic Severity of Knee Osteoarthritis with Symptomatic Parameters: The ROAD Study (2008)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: APLAR 2008-The 13th International Congress of the Asia Pacific League of Associations for Rheumatism
  • 発表場所: Yokohama, Japan
  • 年月日: 20080923-27
• [学会発表] Association of Radiographic Severity of Knee Osteoarthritis with Symptomatic Parameters: The ROAD (Research on Osteoarthritis Against Disability) Study (2008)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: OARSI 2008 World Congress on Osteoarthritis
  • 発表場所: Rome, Italy
  • 年月日: 20080918-21
• [学会発表] Predictive Capacity of Biochemical Markers of Bone Turnover and Endogenous Hormones for Osteoporosis in Men: Ten-year Follow-up of a Japanese Cohort (2008)
  • 著者名/発表者名: Yoshimura N, Oka H, Muraki T, Akune T, Kawaguchi H, Nakamura N
  • 学会等名: 30th Annual Meeting of American Society for Bone and Mineral Research
  • 発表場所: Canada, USA
  • 年月日: 20080900
• [学会発表] Lateral joint srace narrowing on radiographs predicts pain progression in knee osteoarthritis patients: application of fully automatic KOACAD system to OAI public data (2008)
  • 著者名/発表者名: Oka H, Akune T, Muraki S, Nakamura K, Yoshimura N, Kawaguchi H
  • 学会等名: Osteoarthritis Research Society International
  • 発表場所: Roma, Italy
  • 年月日: 20080900
• [学会発表] Fully automatic quantification of knee osteoarthritis severity on standard radiographs by a novel computer assisted system (2007)
  • 著者名/発表者名: Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • 学会等名: OARSI for the 2007 World Congress on Osteoarthritis
  • 発表場所: Ft. Lauderdale, Florida
  • 年月日: 20071200
• [学会発表] Risk factors for radiographic knee osteoarthritis and lumbar spondylosis: the road study (2007)
  • 著者名/発表者名: Muraki S, Oka H, Mabuchi A, En-yo Y, Suzuki M, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: OARSI for the 2007 World Congress on Osteoarthritis
  • 発表場所: Ft. Lauderdale, Florida
  • 年月日: 20071200
• [学会発表] Is osteoporosis related to future incidence of osteoarthritis over 10 years, or vice-versa? (2007)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Kawaguchi H, Nakamura K
  • 学会等名: nnual Meeting of American Society for Bone and Mineral Research
  • 発表場所: Honolulu, USA
  • 年月日: 20070900
• [学会発表] Prevalence of radiographic osteoarthritis of knee and lumbar spine and its association with pain: the research on osteoarthritis against disability (ROAD) study (2007)
  • 著者名/発表者名: Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: Annual Meeting of American Society for Bone and Mineral Research
  • 発表場所: Honolulu, USA
  • 年月日: 20070900
• [学会発表] Fullautomatic measurement of knee osteoarthritis parameters by a novel computer assisted system on standard radiograph (2007)
  • 著者名/発表者名: Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • 学会等名: Osteoarthritis Reseach Society International
  • 発表場所: Salzburg, Austria
  • 年月日: 20070700
• [学会発表] Osteoporosis and osteoarthritis. Is osteoporosis a predictor of the incidence of osteoarthritis, or vice-versa? (2007)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguchi H, Nakamura K
  • 学会等名: Annual meeting of the Europena Calcified Tissue Society
  • 発表場所: Copenhagen, Denmark
  • 年月日: 20070500
• [学会発表] Association of radiographic osteoarthritis of knee and lmbar spine with pain (2007)
  • 著者名/発表者名: Muraki S, Yoshimura N, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • 学会等名: Annual meeting of the Europena Calcified Tissue Society
  • 発表場所: Copenhagen, Denmark
  • 年月日: 20070500
• [学会発表] Prevalence of radiographic osteoarthritis of knee and lumbar spine, and its association wih pain: The research on osteoarthritis against disability (ROAD) studyP (2006)
  • 著者名/発表者名: Kawaguchi H, Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K
  • 学会等名: OARSI 11th World Congress on Osteoarthritis
  • 発表場所: Prague_Czech Republic
  • 年月日: 20061200
• [学会発表] itamin K intake is lower in knee osteoarthritispatients -A general population-based cohort study- The ROAD project (2006)
  • 著者名/発表者名: Oka H, Yoshimura N, Muraki S, Mabuchi A, En-yo Y, Yoshida M, Saiga A, Kawaguchi H, Nakamura K
  • 学会等名: 3rd IOF Asia-Pacific Regional Conference on Osteoporosis and 16th Annual Meeting of the Australian &New Zealand Bone & Mineral Society
  • 発表場所: PortDouglas-Australia
  • 年月日: 20061000
• [学会発表] Prevalence of osteoarthritis at knee and lumbar spine in urban and rural communities: The research on osteoarthritis against disability (ROAD) study (2006)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • 学会等名: Annual Meeting of American Society for Bone and Mineral Research
  • 発表場所: Philadelphia-USA
  • 年月日: 20060900
• [学会発表] Incidence and change of prevalence of vertebral fractures in a rural Japanese community: A 10-year follow-up of The Miyama Cohort (2006)
  • 著者名/発表者名: Yoshimura N, Kinoshita H, Oka H, Muraki S, Kawaguchi H, Nakamura K
  • 学会等名: IOF World Congress onOsteoporosis
  • 発表場所: Toronto-Canada
  • 年月日: 20060600
• [学会発表] Factors associated with mortality following hip fracture (2006)
  • 著者名/発表者名: Oka H, Muraki S, Yoshimura N, Yamamoto S, Kawaguchi H, Nakamura K
  • 学会等名: IOF World Congress on Osteoporosis
  • 発表場所: Toronto-Canada
  • 年月日: 20060600
• [学会発表] Epidemiology of osteoarthritis of the knee in arural Japanese population (2006)
  • 著者名/発表者名: Oka H, Yoshimura N, Suzuki T, Yoshida H, Muraki S, Mabuchi A, Matsudaira K, Kawaguchi H, Nakamura K
  • 学会等名: IOF World Congress on Osteoporosis
  • 発表場所: Toronto-Canada
  • 年月日: 20060600
• [図書] 6章. 生化学的検査.マーカーによる検査. 軟骨代謝マーカー整形外科学大系2巻 (2008)
  • 著者名/発表者名: 岡敬之, 川口浩
  • 総ページ数: pp257-259