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2019 年度 実績報告書

コモンマーモセットにおける視覚的恐怖信号の皮質下処理機構

研究課題

研究課題/領域番号 18F18105
研究機関京都大学

研究代表者

伊佐 正  京都大学, 医学研究科, 教授 (20212805)

研究分担者 CHEN CHIH-YANG  京都大学, 医学(系)研究科(研究院), 外国人特別研究員
研究期間 (年度) 2018-04-25 – 2020-03-31
キーワードmarmoset / innate fear / amygdala / superior colliculus / pupillometry / eye movement
研究実績の概要

I have finished my JSPS fellow and am grateful that JSPS gave me such a good opportunity with funding to support my research. I have achieved several important milestones regarding my research. First, I have recorded eye movements from head-restrained marmosets while they were viewing fearful and non-fearful pictures. It was clear that they spent more time looking at the fearful pictures. I have also successfully tested several different 3D printed implants on the marmosets. Furthermore, I have trained the marmosets with saccade tasks and I am currently writing a manuscript on the results. As a side product, I have also successfully performed microstimulation in marmoset cortex and identified an important brain area related to saccade. I have finished the data acquisition and will start to write the manuscript soon. I also successfully established method for brain microinjection on marmosets and successfully traced the superior colliculus. This is very important result. As what stated last year, I have also performed double injection, one anterograde in the superior colliculus and one retrograde in the amygdala in the same marmoset to exploring the connection between the two brain areas. I am currently testing several types of AAV virus to have good expression for future optogenetic experiments. With the grant provided by JSPS, I have also participated several local and international conferences to present my work and got feedbacks from other researchers. Overall, I believe I have reached several goals I set before and I would like to continue my research about innate fear.

現在までの達成度 (段落)

令和元年度が最終年度であるため、記入しない。

今後の研究の推進方策

令和元年度が最終年度であるため、記入しない。

  • 研究成果

    (7件)

すべて 2019 その他

すべて 雑誌論文 (1件) (うち国際共著 1件、 査読あり 1件) 学会発表 (5件) (うち国際学会 2件、 招待講演 1件) 備考 (1件)

  • [雑誌論文] The Foveal Visual Representation of the Primate Superior Colliculus,2019

    • 著者名/発表者名
      Chih-Yang Chen, Klaus-Peter Hoffmann, Claudia Distler, Ziad M. Hafed
    • 雑誌名

      Current Biology

      巻: 29 ページ: 2109-2119

    • DOI

      10.1016/j.cub.2019.05.040

    • 査読あり / 国際共著
  • [学会発表] Topographic representation of saccade vector in frontal eye field of common marmoset2019

    • 著者名/発表者名
      Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Tadashi Isa
    • 学会等名
      29th NCM Annual Meeting
    • 国際学会
  • [学会発表] Topographic representation of saccade vector in frontal eye field of common marmoset2019

    • 著者名/発表者名
      Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Hirotaka Onoe, Tadashi Isa
    • 学会等名
      Annual Meeting of Japan Neuroscience Society
  • [学会発表] Mapping saccade representation in the frontal cortex of common marmoset2019

    • 著者名/発表者名
      Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Hirotaka Onoe, Tadashi Isa
    • 学会等名
      Annual Meeting of Society for Neuroscience
    • 国際学会
  • [学会発表] Eye movement tracking in head-fixed common marmosets2019

    • 著者名/発表者名
      Chih-Yang Chen, Denis Matrov, Richard Veale, Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Kenichi Miura, Tadashi Isa
    • 学会等名
      第9回日本マーモセット研究会
    • 招待講演
  • [学会発表] Mapping saccadic representation in the frontal cortex of common marmoset2019

    • 著者名/発表者名
      Chih-Yang Chen, Denis Matrov, ,Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Tadashi Isa
    • 学会等名
      第9回日本マーモセット研究会
  • [備考] 京都大学大学院医学研究科高次脳科学講座神経生物学分野

    • URL

      https://nscinbiol.med.kyoto-u.ac.jp/

URL: 

公開日: 2021-01-27  

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