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2021 年度 実績報告書

Microbiome mining: machine learning for discovery of genetic dark matter, metabolic pathways, and ecological processes from metagenomes

研究課題

研究課題/領域番号 18H03367
研究機関国立研究開発法人産業技術総合研究所

研究代表者

延 優  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (40805644)

研究期間 (年度) 2018-04-01 – 2023-03-31
キーワードGenomics / Metabolism / Evolution
研究実績の概要

Through synthesis of machine-learning and phylogenetic analyses, plastics xenobiotics degrading genes in soil bacteria were identified and their evolutionary history/origin was predicted. Through comparison with bacteria living in engineering environments, their evolutionary trends were found to be nearly opposite - one depending on ancient inheritances and the other recent innovations. As a parallel project, combining phylogenetic, genomic, and thermodynamic analyses, a novel recently evolved metabolism in methanogenic archaea was discovered.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

There have been major setbacks due to COVID-19, but progress is being made at a satisfactory pace.

今後の研究の推進方策

In the coming year, further analyses will be performed to identify novel genes evolved recently, presumably to degrade xenobiotic compounds. Through machine learning-facilitated data mining, we will search for operons of novel genes phylogenetically restricted to specific lineages and environmentally restricted to environments exposed to xenobiotic pollutants. The results will also be used to identify lineages that tend to make evolutionary breakthroughs in pollutant remediation.

  • 研究成果

    (1件)

すべて 2021

すべて 雑誌論文 (1件)

  • [雑誌論文] Methanogenic archaea use a bacteria-like methyltransferase system to demethoxylate aromatic compounds2021

    • 著者名/発表者名
      Kurth Julia M.、Nobu Masaru K.、Tamaki Hideyuki、de Jonge Nadieh、Berger Stefanie、Jetten Mike S. M.、Yamamoto Kyosuke、Mayumi Daisuke、Sakata Susumu、Bai Liping、Cheng Lei、Nielsen Jeppe Lund、Kamagata Yoichi、Wagner Tristan、Welte Cornelia U.
    • 雑誌名

      The ISME Journal

      巻: 15 ページ: 3549~3565

    • DOI

      10.1038/s41396-021-01025-6

URL: 

公開日: 2022-12-28  

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