| 研究課題/領域番号 |
18K03473
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
PIGOLOTTI Simone 沖縄科学技術大学院大学, 生物複雑性ユニット, 准教授 (30812193)
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| 研究分担者 |
CHIUCHIU Davide 沖縄科学技術大学院大学, 生物複雑性ユニット, 研究員 (40817491) [辞退]
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| 研究期間 (年度) |
2018-04-01 – 2022-03-31
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| キーワード | Information processing / Polymerization / Kinetic Proofreading / Speed-error tradeoff / Chemical networks / Information theory |
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| 研究実績の概要 |
In the third year of the project, we worked on characterizing the tradeoffs between speed, error, and dissipation in biological error correction. These results will permit to understand how close biological systems are to optimality, which is the main research question of the project.
To achieve this goal, we developed a computational optimization scheme using state of the art numerical algorithms and high-performance computers supported by the project. Thanks to these tools, we were able to characterize the "front" of optimal solutions (in terms of speed, error, and dissipation) for biological error correction.
The PI of the project has also been working on a collaborative Perspective article which explores cellular energetics and, in particular, the energetics of information processing.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
The numerical code for characterizing optimal error correction is now functioning and the vast majority of the results have been already obtained. The project has slowed down due COVID and due to the departure of the co-PI (Davide Chiuchiu) who left OIST a few months ago. Given the advanced status of the project, we are confident that will be able to finish it within FY2021.
The perspective paper on cellular energetics has been already submitted and we expect to have it published during this fiscal year.
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| 今後の研究の推進方策 |
The plan for this fiscal year is to run additional numerical simulations to complement the results for the optimal error correction (in particular for the protein translation model), write and submit a paper with the results, and present the results at international conferences.
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| 次年度使用額が生じた理由 |
The remaining budget will be used for publication expenses, to publish our results in a broad audience, open-access journal. Additional, we plan to disseminate our results at international conferences (either in person or virtually, depending on the evolution of the COVID pandemic).
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