| 研究課題/領域番号 |
18K03473
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
PIGOLOTTI Simone 沖縄科学技術大学院大学, 生物複雑性ユニット, 准教授 (30812193)
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| 研究分担者 |
CHIUCHIU Davide 沖縄科学技術大学院大学, 生物複雑性ユニット, ポストドクトラルスカラー (40817491) [辞退]
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| 研究期間 (年度) |
2018-04-01 – 2023-03-31
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| キーワード | Information processing / Polymerization / Kinetic Proofreading / Speed-error tradeoff / Chemical networks / Information theory |
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| 研究実績の概要 |
Our work on characterizing the tradeoffs between speed, error, and dissipation in biological error correction using optimization theory is nearly finalized. Our work reveals novel non-trivial properties of optimal error correction, and we expect it to have a broad impact in this field. We currently have a working manuscript that we expect to submit in summer.
Our collaborative work on exploring the role of error correction in the context of cellular energetics has been finalized and published (Yang et al., Proceedings of the National Academy of Sciences 118 (26), 2021).
We also initiated a collaboration with Prof. Toyabe (Tohoku university) who is working to experimentally test our theoretical predictions.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
Our work on the tradeoffs between speed, error, and dissipation has been slowed down because of a delay in hiring a new postdoc in charge of finalizing the project (due to COVID-19 restrictions). We now have a postdoc (Shrabani Mondal) that is working on the manuscript and therefore we do not expect any further delays.
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| 今後の研究の推進方策 |
In the last year of the project, we plan to finalize our manuscript on tradeoffs between speed, error, and dissipation, submit it to an open access interdisciplinary journal, and present the results at international conferences.
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| 次年度使用額が生じた理由 |
The remaining budget will be used for publication expenses, to publish our results in an open-access journal. Additionally, we plan to use part of the budget to participate to international conferences, where we will present our results.
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