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2018 年度 実施状況報告書

Synthesis of Lactones and Amino Acids via Reductive Carboxylation Reactions

研究課題

研究課題/領域番号 18K05099
研究機関東京大学

研究代表者

ユー ウージン  東京大学, 大学院理学系研究科(理学部), 特任講師 (70626077)

研究期間 (年度) 2018-04-01 – 2021-03-31
キーワードcarbon dioxide / mutli-component coupling / lactone / lactam / fluorine
研究実績の概要

Our research goal is to develop new multi-component coupling reactions with carbon dioxide to prepare complex organic compounds. We have found that propargyl alcohols can undergo a sequential trans-hydrometallation reaction, and these intermediates can be utilized as substrates for catalytic carboxylation reactions, using copper or silver salts as catalysts, to furnish various lactones. The corresponding propargyl amines were also shown to undergo similar transformations to generate lactams. We also developed a fluorocarboxylation reaction of gem-difluoroalkenes using cesium fluoride and carbon dioxide as coupling partners. We found that this multi-component reaction can be achieved without any additives or catalysts, and various trifluoromethyl carboxylic acids could be obtain in good yields.

現在までの達成度 (区分)
現在までの達成度 (区分)

1: 当初の計画以上に進展している

理由

We were able to get positive results earlier than expected and one project has been published and another project is in the advance stages of completion.

今後の研究の推進方策

The future plan is to continue our investigations into developing multi-component carboxylation reactions. We will finish up our project for the synthesis of lactones and lactams using propargyl alcohols and amines as substrates. In particular, we will focus on using this synthetic methodology to prepare biologically active natural products. Once this project is completed, then we will continue to investigate the general strategy of combining efficient metallation with catalytic carboxylation reactions to prepare complex carboxylic acids and its derivatives. We will also focus our efforts to develop fluorine-based carboxylic acids using gem-difluoroalkenes and carbon dioxide as substrates, and our current focus is on the synthesis fluorinated amino acids.

  • 研究成果

    (4件)

すべて 2019

すべて 雑誌論文 (1件) (うち国際共著 1件、 査読あり 1件) 学会発表 (3件)

  • [雑誌論文] Efficient Synthesis of α-Trifluoromethyl Carboxylic Acids and Esters through Fluorocarboxylation of gem-Difluoroalkenes2019

    • 著者名/発表者名
      Woo-Jin Yoo, Junpei Kondo, Jose A. Rodriguez-Santamaria, Thanh V. Q. Nguyen, Shu Kobayashi
    • 雑誌名

      Angewandte Chemie International Edition

      巻: 58 ページ: 6772-6775

    • DOI

      10.1002/anie.201902779

    • 査読あり / 国際共著
  • [学会発表] Sequential trans-Hydroalumination and Metal-Catalyzed Carboxylation of Propargyl Alcohols and Amines2019

    • 著者名/発表者名
      Wenlong Chen, Woo-Jin Yoo, Shu Kobayashi
    • 学会等名
      The 99th Chemical Society of Japan Annual Meeting
  • [学会発表] gem-ジフルオロアルケンのフルオロカルボキシル化によるトリフルオロメチルカルボン酸及びエステルの合成2019

    • 著者名/発表者名
      近藤 潤平, Jose Alberto Rodriguez-Santamaria, Woo-Jin Yoo, 小林 修
    • 学会等名
      The 99th Chemical Society of Japan Annual Meeting
  • [学会発表] Synthesis of Benzoic Acid Derivatives via Copper-Catalyzed Carboxylation of Unactivated Aryl Silanes2019

    • 著者名/発表者名
      Woo-Jin Yoo, Shu Kobayashi
    • 学会等名
      The 99th Chemical Society of Japan Annual Meeting

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公開日: 2019-12-27  

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