| 研究実績の概要 |
We characterized the role of IFN-γ-inducible immunity-related GTPase Irgb6 in the cell-autonomous response against Toxoplasma gondii (T. gondii), which involves vacuole ubiquitination and breakdown. We show that Irgb6 is capable of binding a specific phospholipid on the parasitophorous vacuole (PV)membrane. Furthermore, the absence of Irgb6 causes reduced targeting of other effector IRG proteins to the PV. This suggests that Irgb6 has a role as a pioneer in the process by which multiple IRG proteins access the PV.
|
