| 研究実績の概要 |
In 2020, we found that homocarnosine and its derivative imidazole dipeptides (carnosine and anserine) are involved in muscle regeneration process. After the muscle injury by cardiotoxin injection, those imidazole dipeptides in the skeletal muscles were rapidly degraded within 12 hr, a long with an up-regulation of its degrading enzyme (carnosinase), while muscle-protein amino acids were not released until 48 hr after the muscle injury. This suggests that imidazole peptides may be involved in energy metabolism in the acute phase during skeletal muscle injury. This suggests a physiological function that protects against excessive degradation of skeletal muscle proteins in sarcopenia.
In addition to the above finding, we found that imidazole dipeptides, carnosine and homocarnosine, possibly prevent cell death of satellite cells upon being activated, implying that these imidazole peptides had a function in supporting satellite cells to undergo myogenesis more efficiently.
These findings suggest new roles of imidazole dipeptides in muscle functions and preventing sarcopenia.
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