| 研究課題/領域番号 |
18K15934
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| 研究機関 | 慶應義塾大学 |
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研究代表者 |
尾崎 真理 慶應義塾大学, 医学部(信濃町), 研究員 (90772286)
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| 研究期間 (年度) |
2018-04-01 – 2021-03-31
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| キーワード | Lung stem cells / High fat diet / aging / alveolar cells |
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| 研究実績の概要 |
In the past year, we have examined previously-unexplored aspects of the negative effects of a HFD on lung stem cells. We have shown that 1)High fat diet (HFD) caused an increase in the number of alveolar type-2 cells. 2)Both aging and HFD caused an increase in inflammatory cell infiltration of the lung. 3)Both aging and HFD impaired various aspects of mitochondrial function. 4)HFD promoted in vitro colony formation by lung stem cells, while aging inhibited it. 5)Switching the diet to a low FD reversed several of the HFD-induced effects.
These results have been published as follows:'High fat diet activates adult mouse lung stem cells and accelerates several aging-induced effects'. Ozaki M et al. Stem Cell Res. 2018 Dec;33:25-35
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
We have completed the first part of our study and have managed to publish. We are now looking more deeply into the mechanisms etc of the study.
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| 今後の研究の推進方策 |
We are now looking more deeply into the mechanisms of our study and are also looking into the effects of a high fat diet with specific lung diseases such as cancer and fibrosis
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