| 研究実績の概要 |
Mice were treated eith normal diet or 5%, 10%, 20% RB supplemented diet, and administered DSS from days 0 to 10. In Control group, body weight was decreased as colitis developed. This was suppressed by RB intake. We also observed that the abundance of Clostridiaceae was higher in RB-fed mice.
Next,normal diet-fed mice feces or RB-fed mice feces were transplanted into germ-free mice, and normal diets was given, and the same DSS experiment was performed. Fecal microbiota transplantation from RB-fed mice suppressed colitis. This strongly suggests that RB suppresses colitis through gut microbiota modulation.
The fecal metabolome profile was dynamically changed by RB intake. Enrichment analysis revealed that RB intervention enriched the tryptophan metabolism pathway.
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