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2018 年度 実施状況報告書

Development of an acoustic imaging modality for absolute and real-time radiotherapy dosimetry

研究課題

研究課題/領域番号 18K18394
研究機関北海道大学

研究代表者

ワン ジェフリー  北海道大学, 国際連携研究教育局, 博士研究員 (80754829)

研究期間 (年度) 2018-04-01 – 2020-03-31
キーワードDosimetry / Acoustic Imaging / Radiotherapy
研究実績の概要

System design for collecting acoustic signals induced by irradiation was completed and hardware procured. A local research LINAC radiotherapy system has been characterized and considerations taken for use in study.

A framework for numerical simulation of both stages of radiotherapy and induced acoustics for the purposes of dosimetry was developed: The 4D human XCAT phantom and GATE/Geant4 Monte Carlo photon/physics simulator for modeling dose deposition, as well as the k-Wave acoustics wave simulator and MATLAB for modeling acoustic wave signal production. Advanced image processing techniques are being reviewed and investigated to deform patient CT scans acquired during the planning stage of therapy, in order to adapt this CT for use during actual irradiation in real-time. Knowledge of exact tissue properties is critical for quantitative acoustic imaging as a method of dosimetry, especially as the tissues deform during 4D treatment due to breathing and movement. Hence, to develop a method of reconstructing the CT image accurately has become the main focus for the project. Current state of the art techniques, as well as the newest technologies for solving such inverse problems are being investigated. Advanced algorithms are also being considered for performance improvements in terms of acoustic signal enhancement.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

System design and development of framework were completed without issue. Experiments are being conducted at scheduled pace.

今後の研究の推進方策

Continue investigation and comparison of methods useful for reconstruction of CT and acoustic imaging for absolute dosimetry, aiming for real-time calculations. Report findings accordingly at academic meetings and scientific journals.

次年度使用額が生じた理由

2018年度に購入希望であった機器の発売が遅れたため、次年度使用額が生じた。
このため、機器の購入を次年度に行うこととし、未使用額はその経費に充てることとしたい。機器の発売が遅れたが、研究は進んでおり、進捗に支障は生じていない。

2018年度に購入希望であった機器の使用目的:body surface as surrogate for internal tissue deformation, required for real-time quantitative acoustic imaging

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公開日: 2019-12-27  

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