変形性関節症の病因解明・治療標的分子同定のための統合研究:ROADプロジェクト

2009 年度 自己評価報告書

• 研究課題/領域番号: 19109007
• 研究種目: 基盤研究(S)
• 配分区分: 補助金
• 研究分野: 整形外科学
• 研究機関: 国立障害者リハビリテーションセンター(研究所) (2011); 東京大学 (2007-2010)
• 研究代表者: 中村 耕三 東京大学, 医学部附属病院, 教授 (60126133)
• 研究期間 (年度): 2007 – 2011
• キーワード: 変形性関節症 / 遺伝子 / ゲノム

研究概要

変形性関節症(OA)の予防・治療法の確立に対する社会的ニーズの高まりは疑いの余地がない。我々は最近、OAの分子メカニズム解明から画期的な予防・治療法の開発を目指した戦略的OA統合研究計画として、ROADプロジェクトを樹立した。本研究課題では、1)軟骨変性制御分子のクローニングと分子ネットワークの解明、2)重症度評価システムの開発、3)遺伝・環境因子の網羅的・系統的探索、の3テーマについての研究を行う。

研究成果

• [雑誌論文] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions (2010)
  • 著者名/発表者名: Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: Arthritis Rheum 62 ページ: 826-836
• [雑誌論文] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells (2010)
  • 著者名/発表者名: Shinoda Y, Kawaguchi H, Higashikawa A, Hirata M, Miura T, Saito T, Nakamura K, Chung UI, Ogata N
  • 雑誌名: J Cell Biochem 109 ページ: 755-763
• [雑誌論文] Locomotive syndrome : disability-free life expectancy and locomotive organ health in a "super-aged" society (2009)
  • 著者名/発表者名: Nakamura K
  • 雑誌名: J Orthop Sci 14 ページ: 1-2
• [雑誌論文] Regulation of osteoarthritis development by Wnt-β-catenin signaling through the endochondral ossification process (2009)
  • 著者名/発表者名: Kawaguchi H
  • 雑誌名: J Bone Miner Res 24 ページ: 8-11
• [雑誌論文] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene (2009)
  • 著者名/発表者名: Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: Arthritis Rheum 60 ページ: 166-178
• [雑誌論文] C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2> (2009)
  • 著者名/発表者名: Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: PLoS ONE 4 ページ: e4543
• [雑誌論文] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : A large-scale population-based study (2009)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Arthritis Rheum 61 ページ: 779-786
• [雑誌論文] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study (2009)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kinoshita H, Yoshida M, Mabuchi A, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: Osteoporosis Int 20 ページ: 999-1008
• [雑誌論文] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells (2009)
  • 著者名/発表者名: Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, Kawaguchi H
  • 雑誌名: Osteoarthritis Cartilage 17 ページ: 1065-1075
• [雑誌論文] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts : the ROAD study (2009)
  • 著者名/発表者名: Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Ann Rheum Dis 68 ページ: 1401-1406
• [雑誌論文] Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study (2009)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: J Bone Miner Metab 27 ページ: 620-628
• [雑誌論文] Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts : The ROAD study (2009)
  • 著者名/発表者名: Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Osteoarthritis Cartilage 17 ページ: 1137-1143
• [雑誌論文] Screening of chondrogenic factors by a real-time fluorescence monitoring cell line ATDC5-C2ER : Identification of sorting nexin 19 as a novel factor (2009)
  • 著者名/発表者名: Kan A, Ikeda T, Saito T, Yano F, Fukai A, Ogata N, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: Arthritis Rheum 60 ページ: 3314-3323
• [雑誌論文] Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly : Dietary survey in a population-based cohort of the ROAD study (2009)
  • 著者名/発表者名: Oka H, Akune T, Muraki S, Mabuchi A, En-yo Y, Yoshida M, Saika A, Sasaki S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: J Orthop Sci 14 ページ: 687-692
• [雑誌論文] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates (2009)
  • 著者名/発表者名: Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
  • 雑誌名: J Biomed Mater Res A 92 ページ: 1273-1282
• [雑誌論文] Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method (2009)
  • 著者名/発表者名: Imai K, Ohnishi I, Matsumoto T, Yamamoto S, Nakamura K
  • 雑誌名: Osteoporos Int 20 ページ: 801-810
• [雑誌論文] Prediction of vertebral strength under loading conditions occurring in activities of daily living using a computed tomography-based nonlinear finite element method (2009)
  • 著者名/発表者名: Matsumoto T, Ohnishi I, Bessho M, Imai K, Ohashi S, Nakamura K
  • 雑誌名: Spine 34 ページ: 1464-1469
• [雑誌論文] Prediction of proximal femur strength using a CT-based nonlinear finite element method : differences in predicted fracture load and site with changing load and boundary conditions (2009)
  • 著者名/発表者名: Bessho M, Ohnishi I, Matsumoto T, Ohashi S, Matsuyama J, Tobita K, Kaneko M, Nakamura K
  • 雑誌名: Bone 45 ページ: 226-231
• [雑誌論文] The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis (2009)
  • 著者名/発表者名: Matsudaira K, Seichi A, Kunogi J, Yamazaki T, Kobayashi A, Anamizu Y, Kishimoto J, Hoshi K, Takeshita K, Nakamura K
  • 雑誌名: Spine 34 ページ: 115-120
• [雑誌論文] Modified fenestration with restorative spinoplasty for lumbar spinal stenosis (2009)
  • 著者名/発表者名: Matsudaira K, Yamazaki T, Seichi A, Hoshi K, Hara N, Ogiwara S, Terayama S, Chikuda H, Takeshita K, Nakamura K
  • 雑誌名: J Neurosurg Spine 10 ページ: 587-594
• [雑誌論文] A "super-aged" society and the "locomotive syndrome" (2008)
  • 著者名/発表者名: Nakamura K
  • 雑誌名: J Orthop Sci 13 ページ: 1-2
• [雑誌論文] Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models (2008)
  • 著者名/発表者名: Kawaguchi H
  • 雑誌名: Mol Cells 25 ページ: 1-6
• [雑誌論文] Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator (2008)
  • 著者名/発表者名: Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung UI, Choi JY
  • 雑誌名: Gene 416 ページ: 53-60
• [雑誌論文] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders (2008)
  • 著者名/発表者名: Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H
  • 雑誌名: Arthritis Rheum 58 ページ: 172-183
• [雑誌論文] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity (2008)
  • 著者名/発表者名: Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI
  • 雑誌名: Dev Cell 14 ページ: 689-699
• [雑誌論文] Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes (2008)
  • 著者名/発表者名: Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: J Clin Invest 118 ページ: 2506-2515
• [雑誌論文] The Distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration : Findings in murine models and in human disease (2008)
  • 著者名/発表者名: Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S
  • 雑誌名: Arthritis Rheum 58 ページ: 2764-2775
• [雑誌論文] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9 (2008)
  • 著者名/発表者名: Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: J Biol Chem 283 ページ: 24682-24689
• [雑誌論文] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis (2008)
  • 著者名/発表者名: Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S
  • 雑誌名: J Biol Chem 283 ページ: 26499-26508
• [雑誌論文] Fully automatic quantification of knee osteoarthritis severity on plain radiographs (2008)
  • 著者名/発表者名: Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H
  • 雑誌名: Osteoarthritis Cartilage 16 ページ: 1300-1306
• [雑誌論文] In vivo assessment of lumbar vertebral strength in elderly women using computed tomography-based nonlinear finite element model (2008)
  • 著者名/発表者名: Imai K, Ohnishi I, Yamamoto S, Nakamura K
  • 雑誌名: Spine 33 ページ: 27-32
• [雑誌論文] A new method for evaluation of fracture healing by echo tracking (2008)
  • 著者名/発表者名: Matsuyama J, Ohnishi I, Sakai R, Bessho M, Matsumoto T, Miyasaka K, Harada A, Ohashi S, Nakamura K
  • 雑誌名: Ultrasound Med Biol 34 ページ: 775-783
• [雑誌論文] Control of fracture reduction robot using force/torque measurement (2008)
  • 著者名/発表者名: Douke T, Nakajima Y, Mori Y, Onogi S, Sugita N, Mitsuishi M, Bessho M, Ohhashi S, Tobita K, Ohnishi I, Sakuma I, Dohi T, Maeda Y, Koyama T, Sugano N, Yonenobu K, Matsumoto Y, Nakamura K
  • 雑誌名: Conf Proc IEEE Eng Med Biol Soc 2008 ページ: 3265-3268
• [雑誌論文] Early functional improvement after a modified ligament reconstruction tendon interposition arthroplasty for thumb basal joint arthritis (2008)
  • 著者名/発表者名: Miura T, Osuka K, Itoh S, Nakagawa T, Kawano H, Nakamura K
  • 雑誌名: Hand Surg 13 ページ: 153-158
• [雑誌論文] Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways (2008)
  • 著者名/発表者名: Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S
  • 雑誌名: Mod Rheumatol 18 ページ: 366-378
• [雑誌論文] S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes (2007)
  • 著者名/発表者名: Saito T, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 雑誌名: EMBO Rep 8 ページ: 504-509
• [雑誌論文] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor (2007)
  • 著者名/発表者名: Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI
  • 雑誌名: FASEB J 21 ページ: 1777-1787
• [雑誌論文] A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner (2007)
  • 著者名/発表者名: Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI
  • 雑誌名: Biochem Biophys Res Commun 357 ページ: 854-860
• [雑誌論文] Identification and characterization of the human SOX6 promoter (2007)
  • 著者名/発表者名: Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI
  • 雑誌名: Biochem Biophys Res Commun 357 ページ: 383-390
• [雑誌論文] Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes (2007)
  • 著者名/発表者名: Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto JI, Takahashi T, Chung UI, Yamaoka H, Asato H, Nakamura K, Takato T, Hoshi K
  • 雑誌名: J Biol Chem 282 ページ: 20407-20415
• [雑誌論文] Diet and lifestyle associated with increased bone mineral density : cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic (2007)
  • 著者名/発表者名: Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K
  • 雑誌名: J Orthop Sci 12 ページ: 317-320
• [雑誌論文] GSK-3β controls osteogenesis through regulating Runx2 activity (2007)
  • 著者名/発表者名: Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI
  • 雑誌名: PLoS ONE 2 ページ: e837
• [雑誌論文] Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis (2007)
  • 著者名/発表者名: Shimizu S, Asou Y, Itoh S, Cung UI, Kawaguchi H, Shinomiya K, Muneta T
  • 雑誌名: Arthritis Rheum 56 ページ: 3358-3365
• [雑誌論文] Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation (2007)
  • 著者名/発表者名: Ogata N, Kawaguchi H, Chung UI, Roth SI, Segre GV
  • 雑誌名: J Biol Chem 282 ページ: 35757-64
• [雑誌論文] Prediction of strength and strain of the proximal femur by a CT-based finite element method (2007)
  • 著者名/発表者名: Bessho M, Ohnishi I, Matsuyama J, Matsumoto T, Imai K, Nakamura K
  • 雑誌名: J Biomech 40 ページ: 1745-1753
• [雑誌論文] Redifferentiation of dedifferentiated bovine articular chondrocytes enhanced by cyclic hydrostatic pressure under a gas-controlled system (2007)
  • 著者名/発表者名: Kawanishi M, Oura A, Furukawa K, Fukubayashi T, Nakamura K, Tateishi T, Ushida T
  • 雑誌名: Tissue Eng 13 ページ: 957-964
• [雑誌論文] Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development
  • 著者名/発表者名: Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H
  • 雑誌名: Nature Med (in press)
• [雑誌論文] Health-related quality of life with vertebral fracture, lumbar spondylosis and knee osteoarthritis in Japanese men : the ROAD study
  • 著者名/発表者名: Muraki S, Akune T, Oka H, En-yo Y, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Arch Osteoporos (in press)
• [雑誌論文] Cohort profile : Research on Osteoarthritis/Osteoporosis Against Disability study
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: Int J Epidemiol (in press)
• [雑誌論文] Title : Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system
  • 著者名/発表者名: Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI
  • 雑誌名: J Bone Miner Metab (in press)
• [学会発表] Molecular backgrounds of cartilage degradation during osteoarthritis progression (Invited Lecture) (2010)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: 2010 Anti-aging and Well-being International Symposium
  • 発表場所: Daegu, Korea
  • 年月日: 2010-02-19
• [学会発表] Therapeutic target molecules for cartilage degradation in osteoarthritis progression (Invited Lecture) (2010)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: System Biology and Drug Discovery
  • 発表場所: Seoul, Korea
  • 年月日: 2010-02-09
• [学会発表] A novel thienoindazole-derivative small compound induces chondrogenic differentiation without promoting hypertrophy through Runx1 (Young Investigator Award) (2009)
  • 著者名/発表者名: Yano F, Ikeda T, Saito T, Ogata N, Hojo H, Kimura A, Takeda S, Takato T, Nakamura K, Kawaguchi H, Chung UI
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Comprehensive control of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis progression (2009)
  • 著者名/発表者名: Saito T, Fukai A, Ikeda T, Yano F, Hirata M, Kan A, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Notch/RBPJk/Hes1 signaling controls terminal differentiation of chondrocytes during endochondral ossification (2009)
  • 著者名/発表者名: Hikata T, Saito T, Takaishi H, Akiyama H, Nakamura T, Yamaguchi A, Matsumoto M, Chiba K, Toyama Y, Kawaguchi H
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Regulator of G protein signaling (RGS)-2 enhances bone anabolic action of PTH through inhibition of Gαq/PKC pathway in osteoblasts (2009)
  • 著者名/発表者名: Ogata N, Yano F, Chikazu D, Chung UI, Nakamura K, Kawaguchi H
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Association of knee osteoarthritis, lumbar spondylosis and osteoporosis with mild cognitive impairment : The ROAD (Research on Osteoarthritis/osteoporosis Against Disability) study (2009)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Health-related quality of life in subjects with vertebral fracture, knee osteoarthritis, lumbar spondylosis and other chronic diseases as well as low back pain and knee pain in a population-based cohort study in Japan : The ROAD study (2009)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Identification of receptor tyrosine kinase-like orphan receptor 2 (ROR2)/WNT5B signaling as a therapeutic target against osteosarcoma (2009)
  • 著者名/発表者名: Morioka K, Matsuda K, Kawano H, Nakamura K, Kawaguchi H, Nakamura Y
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] Requirement of Runx1 for chondrocyte lineage commitment (2009)
  • 著者名/発表者名: Kimura A, Inose H, Fujita K, Yano F, Kawaguchi H, Chung UI, Shinomiya K, Takeda S
  • 学会等名: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Denver, Colorado, USA
  • 年月日: 20090911-20090915
• [学会発表] NF-kappa B family member RelA/p65, a transcription factor of Sox9, is essential for chondrogenic differentiation and skeletal growth (Young Investigator Award) (2009)
  • 著者名/発表者名: Itoh S, Saito T, Ushita M, Ikeda T, Yano F, Ogata N, Chung UI, Nakamura K, Kawaguchi H
  • 学会等名: 2009 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Monteral, Quebec, Canada
  • 年月日: 20090910-20090913
• [学会発表] Distinct transcriptional control of chondrocyte hypertrophy and cartilage degeneration by C/EBP-beta and Runx2 during endochondral ossification (2009)
  • 著者名/発表者名: Hirata M, Kugimiya F, Fukai A, Saito T, Kan A, Higashikawa A, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2009 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Monteral, Quebec, Canada
  • 年月日: 20090910-20090913
• [学会発表] Akt1 in chondrocytes controls cartilage calcification during osteophyte foration in osteoarthritis (2009)
  • 著者名/発表者名: Fukai A, Kawamura N, Saito T, Ikeda T, Ogata N, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2009 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Monteral, Quebec, Canada
  • 年月日: 20090910-20090913
• [学会発表] Association of radiographic severity of lumbar spondylosis with low back pain and related disabilities : The ROAD study (2009)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: 2009 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Monteral, Quebec, Canada
  • 年月日: 20090910-20090913
• [学会発表] Automated quantification and diagnosis of the knee on plain radiographs : The ROAD study (2009)
  • 著者名/発表者名: Oka H, Akune T, Muraki S, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: 2009 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Monteral, Quebec, Canada
  • 年月日: 20090910-20090913
• [学会発表] Cross-linked brush-like structure of surface-modified layers gives high durability to joint replacement (2009)
  • 著者名/発表者名: Kyomoto M, Moro T, Miyaji F, Yamawaki N, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K
  • 学会等名: 22nd annual conference of the European Society for Biomaterials (ESB)
  • 発表場所: Lausanne, Swiss
  • 年月日: 20090907-20090911
• [学会発表] Cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth (2009)
  • 著者名/発表者名: Kawaguchi H, Chikuda H, Kawasaki Y, Hofmann F
  • 学会等名: 4th International Conference on cGMP
  • 発表場所: Rosensburg, Germany
  • 年月日: 20090619-20090621
• [学会発表] Osteoarthritis, osteoporosis and cognitive impairment : the research on osteoarthritis/osteoporosis against disability study (2009)
  • 著者名/発表者名: Yoshimura N. Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 学会等名: 36th European Symposium on Calcified Tissues (ECTS)
  • 発表場所: Vienna, Austria
  • 年月日: 20090523-20090527
• [学会発表] Full-automatic quantification of hip geometry on plain radiographs by a novel computer-assisted system (2009)
  • 著者名/発表者名: Oka H, Akune T, Muraki S, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: 36th European Symposium on Calcified Tissues (ECTS)
  • 発表場所: Vienna, Austria
  • 年月日: 20090523-20090527
• [学会発表] Mouse genetics studies on molecular mechanisms underlying bone and cartilage disorders (Kappa Delta Award Paper Presentation) (2009)
  • 著者名/発表者名: Kawaguchi H, Akune T, Yamada T, Ogata N
  • 学会等名: 55th Annual Meeting of the Orthopaedic Research Society (ORS)
  • 発表場所: Las Vegas, Nevada, USA
  • 年月日: 20090222-20090225
• [学会発表] Molecular backgrounds of cartilage degeneration during osteoarthritis progression (Special Lecture : OARSI-KORS Co-sponsored Symposium) (2009)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: The 35th Annual Meeting of the Korean Orthopaedic Research Society
  • 発表場所: Seoul, Korea
  • 年月日: 2009-10-14
• [学会発表] Transcriptional regulation of cartilage degeneration during osteoarthritis progression (2009)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: The 2nd International Cartilage and Osteoarthritis Symposium (Plenary Lecture)
  • 発表場所: Seoul, Korea
  • 年月日: 2009-10-10
• [学会発表] C/EBP-beta promotes hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2> during endochonderal ossification (Young Investigator Award) (2008)
  • 著者名/発表者名: Kugimiya F, Hirata M, Ohba S, Kawamura K, Ogasawara T, Kawasaki Y, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] A Novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runx1 (Young Investigator Award) (2008)
  • 著者名/発表者名: Yano F, Ikeda T, Saito T, Ogata N, Nakamura K, Takato T, Kawaguchi H, Chung UI
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] Akt1 contributes to chondrocyte calcification during endochondral ossification (2008)
  • 著者名/発表者名: Fukai A, Kawamura N, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] Association of radiographic severity of knee osteoarthritis with symptomatic parameters : The ROAD study (2008)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] Lateral joint space narrowing on radiographs predicts pain progression in knee osteoarthritis patients : Application of fully automatic KOACAD system to OAI public data (2008)
  • 著者名/発表者名: Oka H, Akune T, Muraki S, Nakamura K, Yoshimura N, Kawaguchi H
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] Biocompatible phospholipid polymer grafting on liner surface of artificial hip joints enhances the wear resistance independently of liner cross-link or femoral head material (2008)
  • 著者名/発表者名: Moro T, Takatori Y, Kyomoto M, Ishihara K, Nakamura K, Kawaguchi H
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] Evaluation of the usefulness of biomarkers in knee osteoarthritis or lumbar spondylosis in mass cohort study of Japan (2008)
  • 著者名/発表者名: Morita M, Yamada H, Yoshimura N, Date H, Oka H, Muraki S, Akune T, Ichinose H, Kawaguchi H, Nakamura K
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] Hypoxia-inducible factor 2A (HIF2A) controls sequential steps in the late stage of endochondral ossification (Young Investigator Award) (2008)
  • 著者名/発表者名: Saito T, Ikeda T, Kan A, Hirata M, Fukai A, Yano F, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2008 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Rome, Italy
  • 年月日: 20080918-20080921
• [学会発表] β-catenin directly binds to a specifc intracellular domain of PTH/PTHrP receptor and regulates the signaling in chondrocytes during endochondral ossification. (President's Award) (2008)
  • 著者名/発表者名: Yano F, Chung UI, Ikeda T, Kawasaki Y, Kawaguchi H, Tawfeek HAW, Mahon MJ, Segre GV, Ogata N
  • 学会等名: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Montreal, Quebec, Canada
  • 年月日: 20080912-20080916
• [学会発表] C/EBPβ/p57^<Kip2> signaling maintains transition from proliferation to hypertrophic differentiation of chondrocytes during skeletal growth (2008)
  • 著者名/発表者名: Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Montreal, Quebec, Canada
  • 年月日: 20080912-20080916
• [学会発表] Identification of a transcription factor p63 for transactivation of Wnt9a and Gdf5 causing joint cartilage formation (2008)
  • 著者名/発表者名: Kan A, Ikeda T, Saito T, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Montreal, Quebec, Canada
  • 年月日: 20080912-20080916
• [学会発表] Predictive capacity of biochemical markers of bone turnover and endogenous hormones for osteoporosis in men : ten-year follow-up of a Japanese cohort (2008)
  • 著者名/発表者名: Yoshimura N, Oka H, Muraki S, Akune T, Kawaguchi H, Nakamura K
  • 学会等名: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Montreal, Quebec, Canada
  • 年月日: 20080912-20080916
• [学会発表] Development of high-throughput screening system for osteogenic drugs using cell-based sensor (2008)
  • 著者名/発表者名: Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama K, Yonezawa T, Woo JT, Lichtler AC, Rowe DW, Ikeda T, Nakamura K, Kawaguchi H, Chung UI
  • 学会等名: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Montreal, Quebec, Canada
  • 年月日: 20080912-20080916
• [学会発表] Prevalence and risk factors for radiographic osteoarthritis of the knee and lumbar spine in Japan : The Research on Osteoarthritis Against Disability (ROAD) Study (2008)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Kawaguchi H, Nakamura K
  • 学会等名: 35th European Symposium on Calcified Tissues (ECTS)
  • 発表場所: Barcelona, Spain
  • 年月日: 20080524-20080528
• [学会発表] 変形性膝関節症 : その課題とアプローチの現状 (プレナリーレクチャー) (2008)
  • 著者名/発表者名: 中村耕三, 川口浩, 吉村典子, 阿久根徹, 岡敬之, 村木重之, 馬淵昭彦
  • 学会等名: 第52回日本リウマチ学会総会・学術集会
  • 発表場所: 北海道厚生年金会館、北海道
  • 年月日: 20080420-20080423
• [学会発表] マウスジェネティクスを用いた変形性関節症の分子メカニズムの解明 (シンポジウム : 骨・軟骨疾患の分子生物学) (2007)
  • 著者名/発表者名: 川口浩
  • 学会等名: 第30回日本分子生物学会・第80回日本生化学学会 合同大会 (BMB2007)
  • 発表場所: パシフィコ横浜、神奈川
  • 年月日: 20071211-20071215
• [学会発表] Transcriptional regulation of cartilage degeneration from a mouse OA model (invited lecture) (2007)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: 2007 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Ft. Lauderdale, Florida, USA
  • 年月日: 20071206-20071209
• [学会発表] Transcriptional induction of type X collagen expression and hypertrophic differentiation of chondrocytes by Runx2 during osteoarthritis progression (Young Investigator Award) (2007)
  • 著者名/発表者名: Higashikawa A, Saito T, Kamekura S, Ohba S, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2007 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Ft. Lauderdale, Florida, USA
  • 年月日: 20071206-20071209
• [学会発表] Risk factors for radiographic knee osteoarthritis and lumbar spomdylosis : the ROAD study (Young Investigator Award) (2007)
  • 著者名/発表者名: Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saiga A, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: 2007 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Ft. Lauderdale, Florida, USA
  • 年月日: 20071206-20071209
• [学会発表] Fully automatic quantification of knee osteoarthritis severity on standard radiographs by a novel computer-assisted system (2007)
  • 著者名/発表者名: Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • 学会等名: 2007 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Ft. Lauderdale, Florida, USA
  • 年月日: 20071206-20071209
• [学会発表] Identification of sorting nexin 19 as a novel chondrogenic factor by a real-time fluorescence monitoring cell line ATDC5-S2RD5 (Young Investigator Award) (2007)
  • 著者名/発表者名: Kan A, Ikeda T, Saito T, Ushita M, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 2007 World Congress on Osteoarthritis (OARSI)
  • 発表場所: Ft. Lauderdale, Florida, USA
  • 年月日: 20071206-20071209
• [学会発表] Local application of recombinant human fibroblast growth factor-2 on bone repair (2007)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: The 6th Combined Meeting of the Orthopaedic Research Societies
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20071020-20071024
• [学会発表] Cartilage differentiation and osteoarthritis (2007)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: 19th Annual Meeting of the Korean Society for Molecular Cell Biology (Symposium : Cartilage and Bone)
  • 発表場所: Seoul, Korea
  • 年月日: 20071018-20071019
• [学会発表] GSK-3β inhibits osteoblastic bone formation through suppression of Runx2 transcriptional activity by the phosphorylation at a specific site (Young Investigator Award) (2007)
  • 著者名/発表者名: Hirata M, Kugimiya F, Kawamura N, Ohba S, Nakamura K, Kawaguchi H, Chung UI
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Hypoxia-inducible factor 2α induces type X collagen and promotes hypertrophic differentiation of chondrocytes (2007)
  • 著者名/発表者名: Saito T, Ikeda T, Higashikawa A, Kawasaki Y, Kan A, Ushita M, Ohba S, Yano F, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Identification of a novel chondrogenic factor Sorting Nexin 19 using a real-time fluorescence monitoring cell line ATDC5-S2RD5 (2007)
  • 著者名/発表者名: Kan A, Ikeda T, Saito T, Chung UI, Kawaguchi H
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Transcriptional induction of SOX9 by NF-κB subunit p65 during chondrogenesis (2007)
  • 著者名/発表者名: Ushita M, Ikeda T, Saito T, Kan A, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Transcriptional regulation of type X collagen by Runx2 : Molecular network underlying chondrocyte hypertrophy causing osteoarthritis (2007)
  • 著者名/発表者名: Higashikawa A, Saito T, Kamekura S, Ohba S, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Runx1, co-activator of Sox5, Sox6 and Sox9 (the Sox trio) regulates chondrogenic differentiation (2007)
  • 著者名/発表者名: Yano F, Ikeda T, Saito T, Ogata N, Takeda S, Kimura A, Ohba S, Kugimiya F, Nakamura K, Takato T, Kawaguchi H, Chung UI
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] p63 plays a central role in cartilage development by directly regulating key genes for chondrogenesis (2007)
  • 著者名/発表者名: Ikeda T, Kawaguchi H, Saito T, Kan A, Yano F, Ushita M, Kawasaki Y, Nakamura K, Chung UI
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Is osteoporosis related to future incidence of osteoarthritis over 10 years, or vice-versa? (2007)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguchi H, Nakamura K
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Prevalence of radiographic osteoarthritis of knee and lumbar spine and its association with pain : The Research on Osteoarthritis Against Disability (ROAD) study (2007)
  • 著者名/発表者名: Muraki S, Yoshimura N, Oka H, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • 学会等名: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 20070916-20070919
• [学会発表] Full-automatic measurement of knee osteoarthritis parameters by a novel computer-assisted system on standard radiographs (2007)
  • 著者名/発表者名: Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • 学会等名: 1st Workshops on Imaging-Based Measures of Osteoarthritis
  • 発表場所: Salzburg & Ainring, Germany
  • 年月日: 20070711-20070714
• [学会発表] Insulin/IRS/Akt signaling for maintainance of bone mass and turnover. (Symposia : Mediators of PTH action) (2007)
  • 著者名/発表者名: Kawaguchi H
  • 学会等名: The Endocrine Society's 89th Annual Meeting (ENDO 07)
  • 発表場所: Toronto, Canada
  • 年月日: 20070602-20070605
• [学会発表] Association of radiographic osteoarthritis of knee and lumbar spine with pain. The Research on Osteoarthritis Against Disability (ROAD) study (2007)
  • 著者名/発表者名: Muraki S, Yoshimura N, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Suzuka T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • 学会等名: 34th annual meeting of the European Calcified Tissue Society (ECTS)
  • 発表場所: Copenhagen, Denmark
  • 年月日: 20070505-20070509
• [学会発表] Osteoporosis and osteoarthritis: is osteoporosis a predictor of the incidence of osteoarthritis or vice versa? (2007)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguch H, Nakamura K
  • 学会等名: 34th annual meeting of the European Calcified Tissue Society (ECTS)
  • 発表場所: Copenhagen, Denmark
  • 年月日: 20070505-20070509
• [図書] 新国民病ロコモティブシンドローム 長寿社会は警告する (2010)
  • 著者名/発表者名: 中村耕三
  • 総ページ数: 315
  • 出版者: NHK出版生活人新書
• [図書] ロコモティブシンドローム (監修)「BS朝日テレビテキスト「医療の現場! 4」 (2010)
  • 著者名/発表者名: 中村耕三
  • 総ページ数: 20-35
• [図書] ロコモティブシンドローム特集にあたって (巻頭言)「Modern Physician 30」 (2010)
  • 著者名/発表者名: 中村耕三
  • 総ページ数: 461-463
• [図書] 特集 ロコモティブシンドローム-予防・治療のための運動支援- (巻頭言)「臨床スポーツ医学 27」 (2010)
  • 著者名/発表者名: 中村耕三
• [図書] 関節・軟骨疾患の分子医学 : 変形性関節症の治療標的分子の探索. BIO CLINICA (特集 : 骨・軟骨疾患の分子医学) (2010)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 41-45
• [図書] 変形性関節症の治療ガイドライン. Geriatric Medicine 老年医学 (特集 : 変形性関節症・脊椎症)-診断と治療の最前線- (2010)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 307-314
• [図書] 高齢社会におけるロコモティブシンドローム「運動療法と物理療法 20」 (2009)
  • 著者名/発表者名: 中村耕三
  • 総ページ数: 300-304
• [図書] 筋肉・バランス感覚「NHKここが聞きたい! 名医にQロコモティブシンドローム](共同監修) (2009)
  • 著者名/発表者名: 中村耕三, 遠藤直人, 宗田大
  • 出版者: 日本放送出版協会
• [図書] ひざ痛・骨粗しょう症の新常識! ロコモティブシンドローム (監修)「NHKテレビテキスト きょうの健康4」 (2009)
  • 著者名/発表者名: 中村耕三
  • 総ページ数: 50-61
• [図書] Osteovisual「変形性関節症における軟骨破壊のメカニズム」. Arthritis (2009)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 149-153
• [図書] 遺伝子変異マウスによる変形性関節症の病態解明へのアプローチ. The Bone (特集 : 変形性関節症の基礎と臨床) (2009)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 35-40
• [図書] 変形性関節症 : 研究・診療の現状と問題点. 日本老年病学会雑誌 (骨粗鬆症と変形性関節症 : 研究と診療の最前線) (2009)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 121-127
• [図書] 変形性関節症に対する分子標的治療の展望. CLINICAL CALCIUM (特集 : 変形性関節症 Up-to-date) (2009)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 1608-1614
• [図書] 変形性関節症の疫学研究の現状と問題点 : ROAD (Research on Osteoarthritis Against Disability) 研究. 日本整形外科学会雑誌 (シンポジウム : 変形性膝関節症のマネージメント-最新の臨床エビデンスとエキスパートオピニオン-) (2009)
  • 著者名/発表者名: 川口浩, 阿久根徹, 村木重之, 岡敬之, 中村耕三, 吉村典子
  • 総ページ数: 978-981
• [図書] 変形性関節症 : ROAD 研究が明らかにした実態. 日経メディカル (特集 : 骨粗鬆症と運動器不安定症) (2008)
  • 著者名/発表者名: 川口浩, 阿久根徹, 岡敬之, 村木重之, 中村耕三, 吉村典子
  • 総ページ数: 29-31
• [図書] 変形性関節症の治療標的分子の解明. 骨の remodeling における Dickkopf-1 の役割. リウマチ科 (特集 : 変形性関節症の病態と治療-最近の進歩) (2008)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 498-505
• [図書] OARSIによる股・膝関節OAの治療ガイドライン. Osteoarthritis Update (特集 : 変形性関節症の最新知見) (2008)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 2-5
• [図書] 世界におけるOAの疫学. Osteoarthritis Update (特集 : 変形性関節症の最新知見) (2008)
  • 著者名/発表者名: 村木重之, 川口浩
  • 総ページ数: 10-13
• [図書] OAの画像診断. Osteoarthritis Update (特集 : 変形性関節症の最新知見) (2008)
  • 著者名/発表者名: 岡敬之, 川口浩
  • 総ページ数: 18-21
• [図書] 「運動器リハビリテーションクルズス」第1章 運動を司る構造と機能 : 解剖・生理について. I. 筋骨格系骨. 1. 骨の構造と機能(編集 : 岩谷力、黒沢尚、江藤文夫、赤居正美、星野雄一、飛松好子) (2008)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 7-11
  • 出版者: 南江堂
• [図書] 軟骨のメカニカルストレスと変形性関節症. CLINICAL CALCIUM (特集 : メカニカルストレスと骨) (2008)
  • 著者名/発表者名: 川口浩
  • 総ページ数: 1278-1286
• [図書] コンピュータを用いた大腿骨頸部骨形態自動計測法の開発. Osteoporos Jpn (2008)
  • 著者名/発表者名: 村木重之, 阿久根徹, 岡敬之, 吉村典子
  • 総ページ数: 644-647
• [図書] 変形性関節症の疫学研究. 日本整形外科学会雑誌 (シンポジウム : 変形性関節症の病態解明・診断・治療の新世紀) (2007)
  • 著者名/発表者名: 吉村典子, 岡敬之, 村木重之, 馬淵昭彦, 延與良夫, 吉田宗人, 鈴木隆雄, 山本精三, 川口浩, 中村耕三
  • 総ページ数: 17-21
• [産業財産権] 膝関節診断支援方法及び装置並びにプログラム
  • 発明者名: 中村耕三, 川口浩, 岡敬之
  • 権利者名: 中村耕三, 川口浩, 岡敬之
  • 公開番号: 特開2008-93229