糖尿病性腎症とベイシジン-VEGF/NOシグナルネットワーク

2008 年度 研究成果報告書

• 研究課題/領域番号: 19590947
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 腎臓内科学
• 研究機関: 名古屋大学
• 研究代表者: 湯澤 由紀夫 名古屋大学, 大学院・医学系研究科, 講師 (00191479)
• 研究分担者: 仁木 一郎 大分大学, 医学部, 教授 (10262908)
• 連携研究者: 松尾 清一 名古屋大学, 大学院・医学系研究科, 教授 (70190410) ; 門松 健治 名古屋大学, 大学院・医学系研究科, 教授 (80204519)
• 研究期間 (年度): 2007 – 2008
• キーワード: 糖尿病性腎症 / ベイシジン / VEGF / NO uncoupling

研究概要

糖尿病性腎症の発症機序におけるBasigin-VEGF/NOシグナルの関与について検討した結果、初期段階からVEGF/NO uncouplingにより、血管新生が引き起こされる。また、Basiginは、VEGFのinducerとしては作用せず、Basigin上の糖鎖がE-selectinの新たなリガンドとして働き、糸球体内へのmicroinflammationを誘導し、糖尿病性腎症の発症・進展に関与する。

研究成果

• [雑誌論文] Kidoney regeneration through nephron neogenesis in medaka (2009)
  • 著者名/発表者名: N Watanabe, M Kato, N Suzuki, C Inoue, S Fedorova, Hi Hashimoto, S Maruyama, S Matsuo, Y Wakamatsu
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• [雑誌論文] Aspects of immune dysfunction in end-stage renal disease (2008)
  • 著者名/発表者名: Kato S, Chmielewski M, Honda H, Pecoits-Hilho R, Matsuo S, Yuzawa Y., Tranaeus A, Stenvinkel O and Lindholm
  • 雑誌名: Clinical journal of the American Society of Nephrology 3(5) ページ: 1526-33
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• [雑誌論文] Efficiency of laparoscopic-assisted renal biopsy (2008)
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  • 雑誌名: Clinical Nephrology 70(3) ページ: 203-9
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• [雑誌論文] Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hapten-induced contact hypersensitivity (2008)
  • 著者名/発表者名: Asano Y, Akisawa T, Fukuhara S, Shimojyo F, Matsuo S, Yorioka T, Morita T, Wakita T, Onishi Y, Kurokawa K
  • 雑誌名: Molecular Therapy 16(2) ページ: 387-95
  • 査読あり
• [雑誌論文] Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue (2008)
  • 著者名/発表者名: Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, Matsuo S
  • 雑誌名: Stem Cells and Development (in press)
  • 査読あり
• [雑誌論文] Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis (2008)
  • 著者名/発表者名: Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
  • 雑誌名: Nephrology dialysis transplantation (in press)
  • 査読あり
• [雑誌論文] Prevalence of Pancreatic Cystic Lesions Including Intraductal Papillary Mucinous Neoplasms in Patients With End-Stage Renal Disease on Hemodialysis (2008)
  • 著者名/発表者名: Ishikawa T, Takeda K, Itoh M, Imaizumi T, Oguri K, Takahashi H, Kasuga H, Toriyama T, Matsuo S, Hirooka Y, Itoh A, Kawashima H, Kasugai T, Ohno E, Miyahara R, Ishigami M, Katano Y, Ohmiya N, Niwa Y, Goto H
  • 雑誌名: Pancreas (in press)
  • 査読あり
• [雑誌論文] Characteristics and causes of immune dysfunction related to uremia and dialysis (2008)
  • 著者名/発表者名: Hauser AB, Stinghen AE, Kato S, Bucharles S, Aita C, Yuzawa Y and Pecoits-Filho R
  • 雑誌名: Peritoneal Dialysis International Suppl 3 ページ: 183-7
  • 査読あり
• [雑誌論文] A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab (2008)
  • 著者名/発表者名: Fumiaki Sugiura, Toshihisa Kojima, Takeshi Oguchi, Shirou Urata, Yukio Yuzawa, Akihiro Sakakibara, Hiroki Hayashi, Norihiro Nishimoto, Naoki Ishiguro
  • 雑誌名: Mod Rheumatol (in press)
  • 査読あり
• [雑誌論文] Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis (2008)
  • 著者名/発表者名: Urahama Y, Ohsaki Y, Fujita Y,Maruyama S, Yuzawa Y, Matsuo S, Fujimoto T
  • 雑誌名: Ameircan journal of Pathology 173(5) ページ: 1286-1294
  • 査読あり
• [雑誌論文] Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients (2008)
  • 著者名/発表者名: Shoichi Maruyama, Akihiko Taguchi, Shigejiro Iwashima, Takenori Ozaki, Kaoru Yasuda, Akie Kikuchi-Taura, Toshihiro Soma, Hideki Ishii, Toyoaki Murohara, Hiroshi Takahashi, Hirotake Kasuga, Yoshitaka Kumada, Takanobu Toriyama, Yasuhiko Ito, Hirohisa Kawahara, Yukio Yuzawa and Seiichi Matsuo
  • 雑誌名: Kidney international 74(12) ページ: 1603-9
  • 査読あり
• [雑誌論文] Chronic Kidney Disease Japan Cohort(CKD-JAC)study : design and methods (2008)
  • 著者名/発表者名: Imai E, Matsuo S, Makino H, Watanabe T, Akizawa T, Nitta K, Iimuro S, Ohashi Y, Hishida A ; CKD-JAC Study Group
  • 雑誌名: Hypertension research 31(6) ページ: 1101-1107
  • 査読あり
• [雑誌論文] Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease (2008)
  • 著者名/発表者名: Kumada Y, Aoyama T, Ishii H, Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S, Murohara T
  • 雑誌名: Nephrology dialysis transplantation 23(12) ページ: 3996-4001
  • 査読あり
• [雑誌論文] Chronic kidney disease in Asia (2008)
  • 著者名/発表者名: Imai E, Matsuo S
  • 雑誌名: LANCET 371(9631) ページ: 2147-2148
  • 査読あり
• [雑誌論文] Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy (2008)
  • 著者名/発表者名: Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S
  • 雑誌名: Journal of the American Society of Nephrology 19(9) ページ: 1701-1711
  • 査読あり
• [雑誌論文] Aspects of Immune Dysfunction in End-stage Renal Disease (2008)
  • 著者名/発表者名: Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y, Tranaeus A, Stenvinkel P, Lindholm B
  • 雑誌名: Clinical journal of the American Society of Nephrology 3(5) ページ: 1526-1533
  • 査読あり
• [雑誌論文] Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease (2008)
  • 著者名/発表者名: Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
  • 雑誌名: Clinical journal of the American Society of Nephrology 3(4) ページ: 1034-1040
  • 査読あり
• [雑誌論文] Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. American journal of physiology (2008)
  • 著者名/発表者名: Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S
  • 雑誌名: Renal physiology 294 ページ: 1084-1093
  • 査読あり
• [雑誌論文] A Serine/Threonine Kinase, Cot/Tpl2, Regulates Renal Cell Apoptosis in Ischemia/Reperfusion Injury (2008)
  • 著者名/発表者名: Takaaki Yaomura, Naotake Tsuboi, Yoshinori Urahama, Akinori Hobo, Kenji Sugimoto, Jun Miyoshi, Tetsuya Matsuguchi, Kannagi Reiji, and Seiichi Matsuo, Yukio Yuzawa
  • 雑誌名: Nephrology 13(5) ページ: 397-404
  • 査読あり
• [雑誌論文] Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis (2008)
  • 著者名/発表者名: Aoyama T, Ishii H, Toriyama T, Takahashi H, Kasuga H, Murakami R, Amano T, Uetani T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
  • 雑誌名: Circulation journal 72(1) ページ: 56-60
  • 査読あり
• [雑誌論文] The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy (2008)
  • 著者名/発表者名: Sato W, Kosugi T, Zhang L, Roncal CA, Heinig M, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Grant MB, Croker BP, Nakagawa T
  • 雑誌名: Laboratory investigation 88(9) ページ: 949-961
  • 査読あり
• [雑誌論文] Hishida A Chronic kidney disease perspectives in Japan and the importance of urinalysis screening (2008)
  • 著者名/発表者名: Yamagata K, Iseki K, Nitta K, Imai H, Iino Y, Matsuo S, Makino H
  • 雑誌名: Clinical and experimental nephrology 12(1) ページ: 1-8
  • 査読あり
• [雑誌論文] In vivo silencing of a molecular target by short interfering RNA electroporation : tumor vascularization correlates to delivery efficiency (2008)
  • 著者名/発表者名: Takei Y, Nemoto T, Mu P, Fujishima T, Ishimoto T, Hayakawa Y, Yuzawa Y, Matsuo S, Muramatsu T, Kadomatsu K
  • 雑誌名: In vivo silencing of a molecular target by short interfering RNA electroporation : tumor vascularization correlates to delivery efficiency 7(1) ページ: 211-221
  • 査読あり
• [雑誌論文] Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure (2008)
  • 著者名/発表者名: Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y, Matsuo S
  • 雑誌名: Nephrology dialysis transplantation 23(1) ページ: 110-119
  • 査読あり
• [雑誌論文] Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hepten-induced contact hypersensitivity (2008)
  • 著者名/発表者名: Takuji Ishimoto, Yoshifumi Takei, Yukio Yuzawa, Koji Hanai, Shunji Nagahama, Yuzo Tarumi, Seiichi Matsuo, Kenji Kadomatsu
  • 雑誌名: Molecular Therapy 16(2) ページ: 387-395
  • 査読あり
• [雑誌論文] High mobility group box chromosomal protein 1 in patients with renal diseases (2008)
  • 著者名/発表者名: Fumihiko Sato, Shoichi Maruyama, Hiroki Hayashi, Izumi Sakamoto, Shingo Yamada, Tomonori Uchimura, Yoshiki Morita, Yasuhiko Ito, Yukio Yuzawa, Ikuro Maruyama, Seiichi Matsuo
  • 雑誌名: Nephron Clinical Practice 108(3) ページ: 194-201
  • 査読あり
• [雑誌論文] Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure (2007)
  • 著者名/発表者名: Anas C, Ozaki T, Maruyama S, Yamamoto T, Gotoh M, Ono Y, Matsuo S
  • 雑誌名: International journal of Urology 14(3) ページ: 219-225
  • 査読あり
• [雑誌論文] High levels of complement C3a receptor in the glomeruli in lupus nephritis (2007)
  • 著者名/発表者名: Mizuno M, Blanchin S, Gasque P, Nishikawa K, Matsuo S
  • 雑誌名: American journal of kidney diseases 49(5) ページ: 598-606
  • 査読あり
• [雑誌論文] Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients (2007)
  • 著者名/発表者名: Inaguma D, Tatematsu M, Shinjo H, Suzuki S, Mishima T, Inaba S, Kurata K, Yuzawa Y, Matsuo S
  • 雑誌名: Clinical and experimental nephrology 11(1) ページ: 56-60
  • 査読あり
• [雑誌論文] Efficacy of oral nicorandil in patients with end-stage renal disease: A retrospective chart review after coronary angioplasty in japanese patients receiving hemodialysis (2007)
  • 著者名/発表者名: Ishii H, Toriyama T, Aoyama T, Takahashi H, Yamada S, Kasuga H, Ichimiya S,Kanashiro M, Mitsuhashi H, Maruyama S, Matsuo S, Naruse K, Matsubara T, Murohara T
  • 雑誌名: Clinical therapeutics 29(1) ページ: 110-122
  • 査読あり
• [雑誌論文] Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy (2007)
  • 著者名/発表者名: Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Johnson RJ, Croker B
  • 雑誌名: Journal of the American Society of Nephrology 18(2) ページ: 539-550
  • 査読あり
• [雑誌論文] A Protein Toxin from the Sea Anemone Phyllodiscus semoni Targets the Kidney and Causes a Severe Renal Injury with Predominant Glomerular Endothelial Damage (2007)
  • 著者名/発表者名: Mizuno M., Nozaki M., Morine N., Suzuki N., Nishikawa K., Morgan BP., Matsuo S
  • 雑誌名: Ameircan journal of Pathology 171(2) ページ: 402-414
  • 査読あり
• [雑誌論文] Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation (2007)
  • 著者名/発表者名: Dambara A, Morinaga T, Fukuda N, Yamakawa Y, Kato T, Enomoto A, Asai N, Murakumo Y, Matsuo S, Takahashi M
  • 雑誌名: Experimental cell research 13(17) ページ: 3755-3766
  • 査読あり
• [雑誌論文] Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy (2007)
  • 著者名/発表者名: Kosugi T, Yuzawa Y, Sato W, Arata-Kawai H, Suzuki N, Kato N, Matsuo S, Kadomatsu K
  • 雑誌名: Laboratory investigation 87(9) ページ: 903-913
  • 査読あり
• [学会発表] Characteristics and causes of immune dysfunction related to uremia and dialysis (2009)
  • 著者名/発表者名: Yukio Yuzawa
  • 学会等名: 3rd CKD Forum in Nagoya
  • 発表場所: Nagoya
  • 年月日: 2009-02-15
• [学会発表] Elevated Serum Resistin Level Is Associated with Left Ventricular Hypertrophy in Chronic Kidney Disease Patients on Hemodialysis (2008)
  • 著者名/発表者名: Isao Ito, Shoichi Maruyama, Kiyonari Kato, Hiroshi Takahashi, Takanobu Toriyama, Hirohisa Kawahara, Seiichi Matsuo, Yukio Yuzawa
  • 学会等名: 41rd Annual Meeting of The American Society of Nephrology
  • 発表場所: Philadelphia
  • 年月日: 20081104-08
• [学会発表] Urinary Midkine Is a Sensitive Biomarker of Ischemic Acute Kidney Injury and an Early Ditection of Acute Kidney Injury in Human (2008)
  • 著者名/発表者名: H Hayashi, Y Yuzawa, S Maruyama, W Sato, A Hobo, S Ikematsu, D Sugiyama, K Kadomatsu, S Matsuo
  • 学会等名: 41rd Annual Meeting of The American Society of Nephrology
  • 発表場所: Philadelphia
  • 年月日: 20081104-08
• [学会発表] The Growth Factor Midkine Is a Critical Regulator of Blood Pressure through the Renin Angiotensin Aldosterone System (2008)
  • 著者名/発表者名: A Hobo, T Kosugi, W Sato, T Ishimoto, Y Ito, A Nishiyama, K Kadomatsu, S Matsuo, Y Yuzawa
  • 学会等名: 41rd Annual Meeting of The American Society of Nephrology
  • 発表場所: Philadelphia
  • 年月日: 20081104-08
• [学会発表] URINARY MIDKINE IS A SENSITIVE BIOMARKER OF ACUTE TUBULAR NECROSIS IN HUMAN (2008)
  • 著者名/発表者名: Hiroki Hayashi, Yukio Yuzawa, Shoichi Maruyama, Akinori Hobo, Shinya Ikematsu, Daisuke Sugiyama, Kenji Kadomastu, Seichi Matsuo
  • 学会等名: 45th ERA-EDTA Congress
  • 発表場所: Stockholm
  • 年月日: 20080510-13
• [学会発表] ACUTE KIDNEY INJURY(AKI) IS ONE OF THE MAJOR PROGNOSTIC FACTORS FOR THE PATIENTS WITH ACUTE LUNG INJURY/ACUTE RESPIRATORY DISTRESS SYNDROME (2008)
  • 著者名/発表者名: Sachiyo Suzuki, Hiroki Hayashi, Kei Kurata, Daijyo Inaguma, Kensuke Kataoka, Yasuhiro Kondo, Hiroyuki Taniguchi, Daisuke Sugiyama, Seiichi Matsuo Yukio Yuzawa
  • 学会等名: 45th ERA-EDTA Congress
  • 発表場所: Stockholm
  • 年月日: 20080510-13
• [学会発表] Transmembrane Glycoprotein, Basigin(CD147), Is Involved in the Pathogenesis of Renal Fibrosis (2007)
  • 著者名/発表者名: T Kosugi, N Kato, Y Yuzawa, K Kadomatsu, S Matsuo
  • 学会等名: 40rd Annual Meeting of The American Society of Nephrology
  • 発表場所: San Francisco
  • 年月日: 20071031-1105
• [学会発表] eNOS Deficiency as a Mechanism for Development of Mesangiolysis, Glomerular Microaneurysms and Nodular Glomerulosclerosis in the Mouse Kidney (2007)
  • 著者名/発表者名: W Sato, M Heinig, C Roncal, Y Yuzawa, Mu Wei, S Reungjui, Michael S. Gersch, Byron Croker, Seiichi Matsuo, Richard J. Johnson, Takahiko Nakagawa
  • 学会等名: 40rd Annual Meeting of The American Society of Nephrology
  • 発表場所: San Francisco
  • 年月日: 20071031-1105
• [学会発表] Characteristics and Causes of Immune Dysfunction in Uremia (2007)
  • 著者名/発表者名: Yukio Yuzawa
  • 学会等名: 3rd Asian Chapter Meeting of International Society for Peritoneal Dialysis
  • 発表場所: Hiroshima
  • 年月日: 2007-11-24