| 研究実績の概要 |
When a person is afflicted with a disease, quantities of biomarkers are elevated. This research is focused on developing sensitive and rapid microfluidic systems to detect a wide range of biomarkers. Here, kinetic enhancements in microfluidic bioassay systems were investigated using novel 3D glass devices. Real-time binding events between fluorescently-labelled receptor and ligand antibodies were analyzed. Combining experimental measurements with scaling analysis, two key control dimensionless parameters were proposed to achieve “rapid” and “sensitive” ligand detection: a local Peclet number and a kinetic Damkohler number. Finally, we summarized our observations by providing design rules to support the development of fast and sensitive microfluidic bioassay systems.
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