| 研究実績の概要 |
In FY2022, we investigated interactions of various ligands (anions or small chiral molecules) with porphyrin-type host molecules. The binding of, for example, anions by highly-coloured porphyrin chromophore is of interest from the point-of-view of the development of optical sensors. We analyzed the spectroscopic and structural (by DFT) properties of the formed host-guest complexes between porphyrin and ligand molecules.
We have also studied in detail the nuclear magnetic resonance (NMR) spectral lineshapes of host-guest complexes of porphyrin with chiral organic acids. This improves the detection of chirality by 3D NMR imaging techniques. We also published a systematic approach to study the kinetics of reversible reactions (i.e. host-guest complexation) using NMR lineshape analyses. For this purpose, we have derived analytical solutions of multi-state chemical exchange lineshapes (these solutions were previously unreported).
We also found that a saddle-shaped metallo-porphyrinoid forms a persistently microporous crystalline material. The structure is prepared directly by a simple solution casting process. The material is formed by a unique accumulation of intermolecular interactions involving pi-pi stacking, coordinative interactions at the metallo-porphyrinoid unit, and hydrogen bonding. We used this material as a membrane cover in nanomechanical membrane-type surface-stress sensors (MSS) system for highly sensitive real-time monitoring of gaseous analytes. This system can be suitable for analyses of, for example, human breath for diagnostic purposes.
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