Identifying malaria vaccine candidate antigens using genetic linkage analyses

2021 年度 研究成果報告書

• 研究課題/領域番号: 19K07526
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 審査区分: 小区分49040:寄生虫学関連
• 研究機関: 愛媛大学 (2020-2021); 長崎大学 (2019)
• 研究代表者: カレトン リチャード 愛媛大学, プロテオサイエンスセンター, 教授 (10503782)
• 研究期間 (年度): 2019-04-01 – 2022-03-31
• キーワード: Malaria / Genetics / Genomics

研究成果の概要

We have described here in detail the phenotypic, structural, copy number and nucleotide-level variations among several P. vinckei isolates. We hope that these efforts would greatly aid genetic linkage studies in the future to resolve genotype-phenotype relationships.

自由記述の分野

Parasitology

研究成果の学術的意義や社会的意義

Plasmodium vinckei isolates display a large degree of phenotypic and genotypic diversity and could serve as a resource to study parasite virulence and immunogenicity. Amenability to genetic crossing and transfection make them also suitable for classical and functional genetics to study malaria.