| 研究課題/領域番号 |
19K07765
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
Guillaume Vares 沖縄科学技術大学院大学, 最先端医療機器開発ユニット, 研究員 (10415432)
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| 研究期間 (年度) |
2019-04-01 – 2022-03-31
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| キーワード | chondrosarcoma / cancer stem cells / particle therapy / PARP inhibitors / microRNA |
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| 研究実績の概要 |
We performed two series of carbon-ion irradiations at HIMAC in July and December 2019. Chondrosarcoma cells were treated with Olaparib, Velaparib and/or a mimic for miR-145. RNA and protein samples were collected and flow cytometry experiments were performed. RNA-Seq analysis was performed in January 2020. Preliminary experiments in lower oxygen concentration (physioxia) were also performed. A first manuscript was submitted for publication and is under revision.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Initial experiments were performed smoothly in FY2019, however due to COVID-19, irradiation at HIMAC is stopped until further notice.
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| 今後の研究の推進方策 |
We will put the plan temporarily on hold in FY2020 because I am leaving OIST.
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