鉄過剰状態における造血幹細胞内鉄代謝制御の解明-アナモルシンを中心に-

2021 年度 実績報告書

• 研究課題/領域番号: 19K08861
• 研究機関: 大阪大学
• 研究代表者: 柴山 浩彦 大阪大学, 医学系研究科, 招へい教授 (60346202)
• 研究分担者: 野崎 健司 大阪大学, 医学部附属病院, 医員 (00836413) ; 横田 貴史 大阪大学, 医学系研究科, 准教授 (60403200)
• 研究期間 (年度): 2019-04-01 – 2022-03-31
• キーワード: アナモルシン / 鉄・硫黄クラスター / アポトーシス / 遺伝子欠損マウス / 条件付き遺伝子欠損マウス / 造血幹細胞 / RNA-Seq / Bリンパ球

研究実績の概要

本研究では、申請者らがクローニングした鉄・硫黄クラスター形成に重要な役割を有する抗アポトーシス分子アナモルシン(AM)の造血幹細胞における機能と鉄過剰状態がAMの機能におよぼす影響についての解析をおこなっている。申請者らは、AMコンディショナルノックアウトマウス（AM flox/floxマウス）を作製することで、in vivoにおいて、種々の臓器、細胞のAMを欠損させることを可能としている。最初に、CD19-Cre TgマウスとAM flox/floxマウスを交配することで、CD19を発現するBリンパ球においてAMが欠損するマウスを作成した。その結果、脾臓におけるBリンパ球の最終分化段階である成熟Bリンパ球分画（FO-Ⅰ細胞）の著明な減少を認めた。それに伴い、末梢血やリンパ節のBリンパ球も著明に減少していることを確認した。また、脾臓におけるBリンパ球のアポトーシスが亢進していることも確認し、AMは抗アポトーシス作用によって、Bリンパ球の分化を制御していることが明らかとなった。Bリンパ球特異的AMKOマウスでは、FO-I細胞の減少に加え、脾臓のplasmablast様B細胞の減少や血清IgG3,IgMの減少といったBtk欠損マウスで報告されている特徴が見られていること、また、BCR-Btk pathwayの下流にあるp38MAPKの発現も低下していることから、BCR-Btk-p38MAPKシグナルの減弱が、B細胞特異的AMKOマウスにおけるFO-I細胞が減少する機序の一つと考えている。さらに、MX-Creリコンビナーゼトランスジェニック（MX-Cre-Tg）マウスとAM flox/floxマウスを交配した MX-Cre-Tg/AM flox/floxマウスの造血幹細胞に焦点をあてた研究をおこない、PIPCを投与することで、造血幹細胞のAMを欠損させるマウスを作成した。

研究成果

• [雑誌論文] Impaired B cell terminal differentiation in B cell-specific knockout mice of cell death-defying factor anamorsin. (2022)
  • 著者名/発表者名: Hamanaka Y, Tanimura A, Yokota T, Ezoe S, Ichii M, Nagate Y, Oritani K, Kanakura Y, Hosen N, Shibayama H.
  • 雑誌名: Biochem Biophys Res Commun 巻: 603 ページ: 1-6
  • DOI: 10.1016/j.bbrc.2022.03.018.
  • 査読あり
• [雑誌論文] Efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: an open-label, single-arm, phase 2 study. (2022)
  • 著者名/発表者名: Edahiro Y, Ohishi K, Gotoh A, Takenaka K, Shibayama H, Shimizu T, Usuki K, Shimoda K, Ito M, VanWart SA, Zagrijtschuk O, Qin A, Kawase H, Miyachi N, Sato T, Komatsu N, Kirito K.
  • 雑誌名: Int J Hematol 巻: ー ページ: ー
  • DOI: 10.1007/s12185-022-03341-9.
  • 査読あり
• [雑誌論文] Two-year outcomes of tirabrutinib monotherapy in Waldenstoom's macroglobulinemia. (2022)
  • 著者名/発表者名: Sekiguchi N, Rai S, Munakata W, Suzuki K, Handa H, Shibayama H, Endo T, Terui Y, Iwaki N, Fukuhara N, Tatetsu H, Iida S, Ishikawa T, Iguchi D, Izutsu K.
  • 雑誌名: Cancer Sci 巻: ー ページ: ー
  • DOI: 10.1111/cas.15344.
  • 査読あり
• [雑誌論文] Nivolumab-induced systemic lymphadenopathy occurring during treatment of malignant melanoma: a case report. (2022)
  • 著者名/発表者名: Kubo T, Hino A, Fukushima K, Shimomura Y, Kurashige M, Kusakabe S, Nagate Y, Fujita J, Yokota T, Kato H, Shibayama H, Tanemura A, Hosen N.
  • 雑誌名: Int J Hematol 巻: ー ページ: ー
  • DOI: 10.1007/s12185-022-03312-0.
  • 査読あり
• [雑誌論文] Nilotinib vs. imatinib in Japanese patients with newly diagnosed chronic myeloid leukemia in chronic phase: 10-year follow up of the Japanese subgroup of the randomized ENESTnd trial. (2022)
  • 著者名/発表者名: Nakamae H, Yamamoto M, Sakaida E, Kanda Y, Ohmine K, Ono T, Matsumura I, Ishikawa M, Aoki M, Maki A, Shibayama H.
  • 雑誌名: Int J Hematol 巻: 115 ページ: 33-42
  • DOI: 10.1007/s12185-021-03216-5.
  • 査読あり
• [雑誌論文] Significance of maintenance therapy after HDT/ASCT in symptomatic multiple myeloma: A multicenter retrospective analysis in Kansai Myeloma Forum. (2021)
  • 著者名/発表者名: Nakaya A, Shibayama H, Nakatani E, Shimura Y, Kosugi S, Tanaka H, Fuchida S, Kanda J, Uoshima N, Kaneko H, Imada K, Ohta K, Ito T, Yagi H, Yoshihara S, Hino M, Shimazaki C, Takaori-Kondo A, Kuroda J, Matsumura I, Kanakura Y, Nomura S.
  • 雑誌名: eJHaem 巻: 2 ページ: 765-773
  • 査読あり
• [雑誌論文] A forodesine-based regimen as a therapeutic option for PTCL-NOS with Central nervous system involvement. (2021)
  • 著者名/発表者名: Doi Y, Yokota T, Shibayama H, Matsumoto K, Kurashige M, Nozaki K, Fujita J, Fukushima K, Hosen N.
  • 雑誌名: Leuk Lymphoma 巻: 63 ページ: 1013-1015
  • DOI: 10.1080/10428194.2021.2005043.
  • 査読あり
• [雑誌論文] Low-dose dasatinib in older patients with chronic myeloid leukaemia in chronic phase (DAVLEC): a single-arm, multicentre, phase 2 trial (2021)
  • 著者名/発表者名: Murai K, Ureshino H, Kumagai T, Tanaka H, Nishiwaki K, Wakita S, Inokuchi K, Fukushima T, Yoshida C, Uoshima N, Kiguchi T, Mita M, Aoki J, Kimura S, Karimata K, Usuki K, Shimono J, Chinen Y, Kuroda J, Matsuda Y, Nakao K, Ono T, Fujimaki K, Shibayama H, Sakamoto J, Kimura S.
  • 雑誌名: Lancet Haematol 巻: 8 ページ: e902-e911
  • DOI: 10.1016/S2352-3026(21)00333-1.
  • 査読あり
• [雑誌論文] Carfilzomib, dexamethasone, and daratumumab in Asian patients with relapsed or refractory multiple myeloma: post hoc subgroup analysis of the phase 3 CANDOR trial. (2021)
  • 著者名/発表者名: Suzuki K, Min CK, Kim K, Lee JJ, Shibayama H, Ko PS, Huang SY, Li SS, Ding B, Khurana M, Iida S.
  • 雑誌名: Int J Hematol 巻: 114 ページ: 653-663
  • DOI: 10.1007/s12185-021-03204-9.
  • 査読あり
• [雑誌論文] Phase II study of tazemetostat for relapsed or refractory B-cell non-Hodgkin lymphoma with EZH2 mutation in Japan. (2021)
  • 著者名/発表者名: Izutsu K, Ando K, Nishikori M, Shibayama H, Teshima T, Kuroda J, Kato K, Imaizumi Y, Nosaka K, Sakai R, Hojo S, Nakanishi T, Rai S.
  • 雑誌名: Cancer Sci 巻: 112 ページ: 3627-3635
  • DOI: 10.1111/cas.15040.
  • 査読あり
• [雑誌論文] A phase 2 study of polatuzumab vedotin + bendamustine + rituximab in relapsed/refractory diffuse large B-cell lymphoma. (2021)
  • 著者名/発表者名: Terui Y, Rai S, Izutsu K, Yamaguchi M, Takizawa J, Kuroda J, Ishikawa T, Kato K, Suehiro Y, Fukuhara N, Ohmine K, Goto H, Yamamoto K, Kanemura N, Ueda Y, Ishizawa K, Kumagai K, Kawasaki A, Saito T, Hashizume M, Shibayama H.
  • 雑誌名: Cancer Sci 巻: 112 ページ: 2845-2854
  • DOI: 10.1111/cas.14937.
  • 査読あり
• [雑誌論文] Pretreatment levels of serum soluble interleukin-2 receptor are useful in selecting the treatment regimen for newly diagnosed advanced-stage follicular lymphoma with low tumor burden. (2021)
  • 著者名/発表者名: Nozaki K, Sugahara H, Ueda S, Ishikawa J, Karasuno T, Iida M, Kamae T, Moriyama Y, Kawakami M, Kosugi S, Nakagawa M, Azenishi Y, Sakaniwa R, Kitamura T, Shibayama H.
  • 雑誌名: Int J Hematol 巻: 114 ページ: 217-221
  • DOI: 10.1007/s12185-021-03151-5.
  • 査読あり
• [雑誌論文] Identification of CXCL12-abundant reticular cells in human adult bone marrow. (2021)
  • 著者名/発表者名: Aoki K, Kurashige M, Ichii M, Higaki K, Sugiyama T, Kaito T, Ando W, Sugano N, Sakai T, Shibayama H; HANDAI Clinical Blood Club, Takaori-Kondo A, Morii E, Kanakura Y, Nagasawa T.
  • 雑誌名: Br J Haematol 巻: 193 ページ: 659-668
  • DOI: 10.1111/bjh.17396.
  • 査読あり
• [雑誌論文] High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder. (2021)
  • 著者名/発表者名: Saito H, Miyoshi H, Shibayama H, Toda J, Kusakabe S, Ichii M, Fujita J, Fukushima K, Maeda T, Mizuki M, Oritani K, Seto M, Yokota T, Kanakura Y, Hosen N, Ohshima K.
  • 雑誌名: Int J Hematol 巻: 114 ページ: 53-64
  • DOI: 10.1007/s12185-021-03129-3.
  • 査読あり
• [雑誌論文] Oral ixazomib, lenalidomide, and dexamethasone for newly diagnosed transplant-ineligible multiple myeloma patients. (2021)
  • 著者名/発表者名: Facon T, Venner CP, Bahlis NJ, Offner F, White D, Karlin L, Benboubker L, Rigaudeau S, Rodon P, Voog E, Yoon SS, Suzuki K, Shibayama H, Zhang X, Twumasi-Ankrah P, Yung G, Rifkin RM, Moreau P, Lonial S, Kumar SK, Richardson PG, Rajkumar SV.
  • 雑誌名: Blood 巻: 137 ページ: 3616-3628
  • DOI: 10.1182/blood.2020008787.
  • 査読あり
• [雑誌論文] Safety and Antitumor Activity of Acalabrutinib for Relapsed/Refractory B-cell Malignancies: A Japanese Phase I Study. (2021)
  • 著者名/発表者名: Izutsu K, Ando K, Ennishi D, Shibayama H, Suzumiya J, Yamamoto K, Ichikawa S, Kato K, Kumagai K, Patel P, Iizumi S, Hayashi N, Kawasumi H, Murayama K, Nagai H.
  • 雑誌名: Cancer Sci 巻: 112 ページ: 2405-2415
  • DOI: 10.1111/cas.14886.
  • 査読あり
• [雑誌論文] Plateau is a prognostic factor of lenalidomide therapy for previously treated multiple myeloma. (2021)
  • 著者名/発表者名: Takakuwa T, Ohta K, Nakatani E, Ito T, Kaneko H, Fuchida SI, Shimura Y, Yagi H, Shibayama H, Kanda J, Uchiyama H, Kosugi S, Tanaka H, Kawata E, Uoshima N, Ishikawa J, Shibano M, Karasuno T, Shindo M, Shimizu Y, Imada K, Kanakura Y, Kuroda J, Hino M, Nomura S, Takaori-Kondo A, Shimazaki C, Matsumura I.
  • 雑誌名: Hematol Oncol 巻: 39 ページ: 349-357
  • DOI: 10.1002/hon.2863.
  • 査読あり
• [雑誌論文] Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease. (2021)
  • 著者名/発表者名: Konishi T, Kusakabe S, Hino A, Inamoto K, Yoshifuji K, Kiridoshi Y, Takeshita K, Sasajima S, Toya T, Igarashi A, Najima Y, Kobayashi T, Doki N, Motooka D, Nakamura S, Suyama M, Suda W, Shiota A, Atarashi K, Hattori M, Honda K, Yokota T, Ohashi K, Shibayama H, Fukushima K, Kakihana K.
  • 雑誌名: Bone Marrow Transplant 巻: 56 ページ: 1728-1731
  • DOI: 10.1038/s41409-021-01249-2.
  • 査読あり
• [雑誌論文] Flow cytometry analysis of peripheral Tregs in patients with multiple myeloma under lenalidomide maintenance. (2021)
  • 著者名/発表者名: Nozaki K, Fujioka Y, Sugiyama D, Ishikawa J, Iida M, Shibata M, Kosugi S, Nishikawa H, Shibayama H.
  • 雑誌名: Int J Hematol 巻: 113 ページ: 772-774
  • DOI: 10.1007/s12185-021-03093-y.
  • 査読あり
• [雑誌論文] Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia. (2021)
  • 著者名/発表者名: Shingai Y, Yokota T, Okuzaki D, Sudo T, Ishibashi T, Doi Y, Ueda T, Ozawa T, Nakai R, Tanimura A, Ichii M, Shibayama H, Kanakura Y, Hosen N.
  • 雑誌名: Stem Cells 巻: 39 ページ: 723-736
  • DOI: 10.1002/stem.3348.
  • 査読あり
• [雑誌論文] Outcomes of ixazomib/lenalidomide/dexamethasone for multiple myeloma: A multicenter retrospective analysis. (2021)
  • 著者名/発表者名: Takakuwa T, Yamamura R, Ohta K, Kaneko H, Imada K, Nakaya A, Fuchida SI, Shibayama H, Matsuda M, Shimazu Y, Adachi Y, Kosugi S, Uchiyama H, Tanaka H, Hanamoto H, Shimura Y, Kanda J, Onda Y, Uoshima N, Yagi H, Yoshihara S, Hino M, Shimazaki C, Takaori-Kondo A, Kuroda J, Matsumura I, Kanakura Y, Nomura S.
  • 雑誌名: Eur J Haematol 巻: 106 ページ: 555-562
  • DOI: 10.1111/ejh.13586.
  • 査読あり
• [雑誌論文] Brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine in patients with advanced-stage, classical Hodgkin lymphoma: a prespecified subgroup analysis of high-risk patients from the ECHELON-1 study. (2021)
  • 著者名/発表者名: Hutchings M, Radford J, Ansell SM, Sureda A, Connors JM, Shibayama H, Abramson JS, Chua NS, Friedberg JW, LaCasce AS, Molina L, Engley G, Fenton K, Jolin H, Liu R, Gautam A, Gallamini A.
  • 雑誌名: Hematol Oncol 巻: 39 ページ: 185-195
  • DOI: 10.1002/hon.2838.
  • 査読あり
• [学会発表] Clinical Significance of FLT3 Mutations in a Comprehensive NGS Multicenter Study of AML: HM-Screen-Japan 01 (2021)
  • 著者名/発表者名: Kentaro Fukushima, Hirohiko Shibayama, SungGi Chi, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Makoto Yoshimitsu, Kenji Ishitsuka, Takaaki Ono, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinori Nakamura, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: The American Society of Hematology 63rd Annual Meeting
  • 国際学会
• [学会発表] Very Low-Dose Dasatinib Is a Safe and Effective Therapy for Elderly Patients with Newly-Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Results from the Davlec Study, a Single-Arm, Multicenter, Phase 2 Trial (2021)
  • 著者名/発表者名: Takashi Kumagai, Kazunori Murai, Hiroshi Ureshino, Hideo Tanaka, Takaaki Ono, Katsumichi Fujimaki, Hirohiko Shibayama, Chisaki Mizumoto, Tomoharu Takeoka, Katsuhiro Io, Takeshi Kondo, Masatomo Miura, Yosuke Minami, Takayuki Ikezoe, Jun Imagawa, Ayako Takamori, Atsushi Kawaguchi, Junichi Sakamoto, Shinya Kimura
  • 学会等名: The American Society of Hematology 63rd Annual Meeting
  • 国際学会
• [学会発表] Two-year follow-up data of Phase II study of Tirabrutinib, a second-generation bruton’s tyrosine kinase inhibitor, in patients with treatment-naive or relapsed/refractory Waldenstrom’s macroglobulinemia. (2021)
  • 著者名/発表者名: Kenshi Suzuki, Naohiro Sekiguchi, Shinya Rai, Wataru Munakata, Hiroshi Handa, Hirohiko Shibayama, Tomoyuki Endo, Yasuhito Terui, Noriko Iwaki, Noriko Fukuhara, Hiro Tatetsu, Shinsuke Iida, Takayuki Ishikawa, Daisuke Iguchi, Koji Izutsu
  • 学会等名: The American Society of Hematology 63rd Annual Meeting
  • 国際学会
• [学会発表] Late vs Early Response and Depth of Response Are Associated with Improved Outcomes in Newly Diagnosed Multiple Myeloma (NDMM) Patients (pts) Treated with Ixazomib-Lenalidomide-Dexamethasone (IRd) or Placebo-Lenalidomide-Dexamethasone (pbo-Rd) in the Phase 3 TOURMALINE-MM2 Trial (2021)
  • 著者名/発表者名: Paul G. Richardson, Thierry Facon, Sophie Rigaudeau, Eric Voog, Sung-Soo Yoon, Kenshi Suzuki, Hirohiko Shibayama, Xiaoquan Zhang, Arun Kumar, Philip Twumasi-Ankrah, Richard Labotka, Robert M. Rifkin, Sagar Lonial, Shaji K Kumar, S. Vincent Rajkumar, Philippe Moreau
  • 学会等名: The American Society of Hematology 63rd Annual Meeting
  • 国際学会
• [学会発表] Genomic analysis of TP53 mutations in a multicenter NGS study of AML: HM-SCREEN-Japan01. (2021)
  • 著者名/発表者名: Kentaro Fukushima, SunGi Chi, Hirohiko Shibayama, Nohoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Very elderly patients with myeloma: a multicenter retrospective analysis from Kansai Myeloma forum. (2021)
  • 著者名/発表者名: Yusuke Okayama, Teruhito Takakuwa, Yuji Shimura, Nobuhiko Uoshima, Satoshi Yoshihara, Junya Kanda, Hirohiko Shibayama, Kentaro Fukushima, Kensuke Ota, Hideo Yagi, Shosaku Nomura, Chihiro Shimazaki, Itaru Matsumura, Akifumi Takaori, Naoki Hosen, Masayuki Hino, Junya Kuroda
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Nobel web application predicting patient-specific prognosis in MM from KMF using machine learning. (2021)
  • 著者名/発表者名: Teruhito Takakuwa, Hiroshi Okamura, Shin-ichi Fuchida, Yuji Shimura, Junya Kanda, Nobuhiko Uoshima, Hirohiko Shibayama, Satoshi Yoshihara, Hideo Yagi, Masayuki Hino, Yuzuru Kanakura, Junya Kuroda, Akifumi Takaori, Chihiro Shimazaki, Itaru Matsumura, Shosaku Nomura
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Efficacy of elotuzumab plus lenalidomide and dexamethasone for MM: A retrospective analysis from KMF. (2021)
  • 著者名/発表者名: Shin-ichi Fuchida, Tomoki Ito, Kensuke Ota, Hirohiko Shibayama, Kentaro Fukushima, Hirokazu Tanaka, Yuji Shimura, Kazunori Imada, Hideo Yagi, Satoshi Yoshihara, Masayuki Hino, Naoki Hosen, Akifumi Takaori, Itaru Matsumura, Shosaku Nomura, Chihiro Shimazaki, Junya Kuroda
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Using ImmunoFISH to determine lymphoid neoplasm relapse after sex-mismatched HSCT or PTLD occurrence (2021)
  • 著者名/発表者名: Ryumei Kurashige, Masako Kurashige, Yosuke Okada, Kohei Higuchi, Akihisa Hino, Takako Miyamura, Michiko Ichii, Kentaro Fukushima, Makoto Takeuchi, Akihisa Sawada, Masami Inoue, Hirohiko Shibayama, Eiichi Morii, Naoki Hosen
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] A Phase 2b study of an oral HDAC inhibitor HBI-8000 in patients with relapsed or refractory ATL (2021)
  • 著者名/発表者名: Tatsuro Jo, Atae Utsunomiya, Koji Izutsu, Hirohiko Shibayama, Kazuya Shimoda, Yasushi Takamatsu, Kuniko Takano, Kunihiro Tsukasaki, Jun Taguchi, Kentaro Yonekura, Shinichi Makita, Mireille Gillings, Hiroshi Onogi, Kensei Tobinai
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Genomic analysis of relapsed AML with RUNX1-RUNX1T1 in a comprehensive NGS multicenter study of AML (2021)
  • 著者名/発表者名: Seiichiro Katagiri, Daigo Akabane, Akihiko Gotoh, SunGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Genetic features of AML with MLL-rearrangement and NPM1 mutation: HM-SCREEN-JAPAN01 (2021)
  • 著者名/発表者名: SunGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Genetic features of AML with normal karyotype: HM-SCREEN-JAPAN01 (2021)
  • 著者名/発表者名: SunGi Chi, Masamitsu Yanada, Kazuhito Yamamoto, Naoko Hosono, Takahiro Yamauchi, Kentaro Fukushima, Hirohiko Shibayama, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Genetic features of AML with IDH1/IDH2 mutation: HM-SCREEN-JAPAN01 (2021)
  • 著者名/発表者名: Hirotaka Nakamura, SunGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] A mutation profiling multicenter study of patients with AML: HM-SCREEN-JAPAN01 (2021)
  • 著者名/発表者名: Naoko Hosono, Takahiro Yamauchi, SunGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] A case of PTCL-NOS with central nervous system involvement successfully treated with oral forodesine. (2021)
  • 著者名/発表者名: Yukio Doi, Takafumi Yokota, Hirohiko Shibayama, Kana Matsumoto, Masako Kurashige, Kenji Nozaki, Kouki Yoshida, Makiko Suga, Midori Koike, Jun Toda, Keigo Akuta, Akihisa Hino, Tomoaki Ueda, Yasuhiro Nagate, Jiro Fujita, Kentaro Fukushima, Naoki Hosen
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] A Phase 2b study of an oral HDAC inhibitor HBI-8000 in patients with relapsed or refractory PTCL (2021)
  • 著者名/発表者名: Hidetsugu Kawai, Jun Ando, Ilseung Choi, Junya Kuroda, Mitsutoshi Kurosawa, Hong Ghi Lee, Jae Hoon Lee, Won Sik Lee, Hironobu Minami, Hirokazu Nagai, Hirohiko Shibayama, Takeo Shindo, Kenji Tsukamoto, Kunihiro Tsukasaki, Toshiki Uchida, Shinya Rai, Deok Hwan Yang, Shinichiro Yoshida, Mireille Gillings, Kensei Tobinai
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Genetic features of AML requiring hematopoietic stem cell transplantation: HM-SCREEN-JAPAN01 (2021)
  • 著者名/発表者名: Motoki Eguchi, Takanobu Morishita, SunGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会
• [学会発表] Clinical significance of FLT3 mutations in a NGS multicenter study of AML: HM-SCREEN-JAPAN01 (2021)
  • 著者名/発表者名: Kentaro Fukushima, Hirohiko Shibayama, SunGi Chi, Nohoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinobu Nakamura, Suguru Fukuhara, Koji Izutsu, Hirohiko Yamauchi, Junichiro Yuda, Yosuke Minami
  • 学会等名: 第83回日本血液学会学術集会