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2020 年度 実施状況報告書

糖尿病に伴う多臓器障害を予防する低・中強度運動療法の開発:VEGFに着目して

研究課題

研究課題/領域番号 19K11543
研究機関東邦大学

研究代表者

Jesmin Subrina  東邦大学, 医学部, 博士研究員 (60374261)

研究分担者 渡部 厚一  筑波大学, 体育系, 准教授 (30447247)
河野 了  筑波大学, 医学医療系, 講師 (90323295)
研究期間 (年度) 2019-04-01 – 2022-03-31
キーワード糖尿病 / 合併症 / 運動
研究実績の概要

In the first year, we used a established rat model in the pre-diabetic stage of OLETF rats, a model of T2DM, with LETO rats as genetic control. We clearly demonstrated that Four months of mild or moderate exercise from pre-diabetes was effective in significant normalization of glycemic parameters with hippocampal molecular normalization through MCT2, glycogen, and BDNF levels with substantial improvement of memory dysfunction in early-T2DM rats. In the 2nd year, from various organ investigations, we found the hippocampus is affected earlier than other organs like the heart, kidney. Here we investigated whether a daily walking intervention could improve the fasting blood sugar level in newly diagnosed diabetes mellitus participants in rural Bangladesh who were not on medication. A rural population of 1,045 people in Bangladesh was screened for diabetes mellitus. One hundred fifty-six people, including 87 diabetes mellitus participants, went through a 5-month daily walking program (twice daily, 1.5 km walking each time). In our initial screening, the prevalence of newly diagnosed diabetes mellitus cases was 8.5% in the rural population. The mean fasting blood sugar level in these new diabetes mellitus cases was 10.0 ± 0.33 mmol/L. After five months of exercise, both the fasting blood sugar and 2h OGTT sugar levels were significantly improved, and no DM (diabetes mellitus) cases were on medication. The current research findings show that a walking program can be a potential lifestyle intervention to combat the diabetes mellitus epidemic in a poor rural context in Bangladesh.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

Reason and status: Although COVID-19 is affecting a lot of works, fortunately, the current research is on the right track both from the contexts of the timeline and the number of research activities scheduled to be done (100% done with target milestone achievement) with the proper management of project budget and funding.
We did the target works in the first year and also the scheduled works in the 2nd year. In this Covid-19 crisis, we published the human study this year in February. We could also continue animal studies and expect to complete all the works by this year.

今後の研究の推進方策

In the 3rd year, we will do more focus on human study. We already published a part of that research. Now we are conducting the survey with different exercise regimens and duration. Also, we include patients from various degrees of diabetes. This year also, we will have a number of mobile health screening camps in rural Bangladesh through screening and assessing diabetes by OGTT. In Bangladesh, in a rural setting, it is challenging to measure HBA1c for diabetes screening.
Also, we continue animal studies. Here we intend to use fatty diet-induced mice diabetes model and will conduct the exercise. High fatty diet-induced pre-DM and DM mice will be used. Here we will also focus on VEGF angiogenic signaling cascade and the related apoptosis signaling cascade as a molecular investigation.

次年度使用額が生じた理由

2020年度は新型コロナウイルス感染症の拡大が続き、予定していた海外からの試薬が届かないことがあったため、次年度使用額が生じた。次年度は本研究の最終年度であり、予定していた試薬を全て購入し、研究の成果を出す予定である。

  • 研究成果

    (13件)

すべて 2021 2020 その他

すべて 国際共同研究 (1件) 雑誌論文 (7件) (うち国際共著 7件、 査読あり 7件、 オープンアクセス 7件) 学会発表 (5件) (うち国際学会 5件、 招待講演 5件)

  • [国際共同研究] HDRCRP/Bogra Medical College(バングラデシュ)

    • 国名
      バングラデシュ
    • 外国機関名
      HDRCRP/Bogra Medical College
  • [雑誌論文] Association between self-reported empathy and level of physical activity in healthy young adults2021

    • 著者名/発表者名
      Shima Takeru、Jesmin Subrina、Nakao Hayato、Tai Kentaro、Shimofure Tomonori、Arai Yoshihiro、Kiyama Keiko、Onizawa Yoko
    • 雑誌名

      The Journal of Physical Fitness and Sports Medicine

      巻: 10 ページ: 45~49

    • DOI

      10.7600/jpfsm.10.45

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Vigorous-intensity physical activity associates with self-reported empathy in healthy young adults2021

    • 著者名/発表者名
      Takeru Shima , Subrina Jesmin , Hayato Nakao , Kentaro Tai , Tomonori Shimofure , Yoshihiro Arai , Keiko Kiyama , Yoko Onizawa
    • 雑誌名

      The Journal of Sports Medicine and Physical Fitness

      巻: - ページ: -

    • DOI

      10.23736/S0022-4707.21.12230-3

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Effects of Selective Endothelin Receptor Antagonist on Vegf Signaling System in Diabetic Penis: A Possible Clinical Implication for Diabetes Induced Erectile Dysfunction2021

    • 著者名/発表者名
      Adil Maqbool, Subrina Jesmin, Chishimba N Mowa, Sayeeda Nusrat Sultana,Nobutake Shimojo, Yujiro Matsuishi, Takeru Shima, Naoto Yamaguchi, Takashi Miyauchi, Satoru Kawano, Takashi Miyauchi
    • 雑誌名

      Cardiology & Vascular Research

      巻: 5 ページ: 1-7

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Daily walking habit reduces fasting blood sugar level in newly diagnosed diabetic participants in rural Bangladesh2021

    • 著者名/発表者名
      Jesmin Subrina、Shima Takeru、Yamaguchi Naoto、Sohael Farzana、Maqbool Adil、Rahman Arifur、Moroi Masao、Shimojo Nobutake、Kawano Saturo、Watanabe Koichi、Takeda Fumi、Soya Hideaki
    • 雑誌名

      The Journal of Physical Fitness and Sports Medicine

      巻: 10 ページ: 85~97

    • DOI

      10.7600/jpfsm.10.85

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Small Amounts of Physical Activity During the COVID-19 Pandemic May Contribute to Improve Empathy in Young Adults: An Observational Study2021

    • 著者名/発表者名
      Takeru Shima, Subrina Jesmin, Hayato Nakao, Kentaro Tai, Tomonori Shimofure, Yoshihiro Arai, Keiko Kiyama, and Yoko Onizawa
    • 雑誌名

      Asia Pacific Journal of Public Health

      巻: - ページ: 1-3

    • DOI

      10.1177/10105395211016333

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Severe COVID-19 Infection Associated with Endothelial Dysfunction Induces Multiple Organ Dysfunction: A Review of Therapeutic Interventions2021

    • 著者名/発表者名
      Matsuishi Yujiro、Mathis Bryan J.、Shimojo Nobutake、Subrina Jesmin、Okubo Nobuko、Inoue Yoshiaki
    • 雑誌名

      Biomedicines

      巻: 9 ページ: 279~279

    • DOI

      10.3390/biomedicines9030279

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Short-term lifestyle intervention program through daily walking improves circulatory low HDL level in rural Bangladeshi women2020

    • 著者名/発表者名
      Jesmin Subrina、Sohael Farzana、Rahman Md. Arifur、Maqbool Adil、Islam Md. Majedul、Shima Takeru、Shimojo Nobutake、Moroi Masao、Yamaguchi Naoto、Watanabe Koichi、Takeda Fumi、Soya Hideaki
    • 雑誌名

      The Journal of Physical Fitness and Sports Medicine

      巻: 9 ページ: 181~190

    • DOI

      10.7600/jpfsm.9.181

    • 査読あり / オープンアクセス / 国際共著
  • [学会発表] Diabetes and erectile dysfunction2021

    • 著者名/発表者名
      Jesmin Subrina
    • 学会等名
      invited by Diabetes Prevention Society, Bangladesh
    • 国際学会 / 招待講演
  • [学会発表] Effects of exercise on diabetic complications2020

    • 著者名/発表者名
      Jesmin Subrina
    • 学会等名
      Symposium: Diabetes Education(Online lecture)
    • 国際学会 / 招待講演
  • [学会発表] Diabetes and memory complications2020

    • 著者名/発表者名
      Jesmin Subrina
    • 学会等名
      A special online conference arranged by HDRCRP, Bangladesh
    • 国際学会 / 招待講演
  • [学会発表] Exercise regimen on DM prevention: an example from Bangladeshi rural women2020

    • 著者名/発表者名
      Jesmin Subrina
    • 学会等名
      Poster presentation arranged by Bangladesh physical activity association
    • 国際学会 / 招待講演
  • [学会発表] What we can do diabetes prevention2020

    • 著者名/発表者名
      Jesmin Subrina
    • 学会等名
      invited by Bogra Medical College, Bangladesh
    • 国際学会 / 招待講演

URL: 

公開日: 2021-12-27  

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