| 研究課題/領域番号 |
19K15388
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| 研究機関 | 東北大学 |
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研究代表者 |
DAO THINGOCANH 東北大学, 多元物質科学研究所, 助教 (10793903)
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| 研究期間 (年度) |
2019-04-01 – 2022-03-31
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| キーワード | silk protein / gold / hybrid nanomaterials / drug delivery / cancer therapy |
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| 研究実績の概要 |
The research aims to be the first establishment of Au/silk nanoparticles for delivery, imaging and targeting in cancer treatment, prepared by a facile co-precipitation method. At the present stage, silk nanoparticles were obtained in uniform morphology, with the size can be tuned from 10 to 100 nm, and the surface charges can be modified by using different dissolving solution, brings out the possibility of loading different types of drugs. The obtained silk nanoparticles show good drug uptakes, adequate stability and almost no toxicity at cellular level. Au nanoparticles were incorporated into silk matrix via co-precipitation method, with the structure confirmed by TEM measurements. The obtained hybrid nanoparticles display tunable plasmonic properties through varying the contents of gold.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The first three targets of the research plan, including establishing the fabrication method for silk and gold/silk nanoparticles, are close to complete. The research is progressing to the investigation of in vitro behaviors of these nanocarriers with various compositions and structures. As a preliminary result, when gold nanoparticles are incorporated into silk matrix, the obtained hybrid particles have assembled properties to that of silk nanoparticles, in addition to the dual pH- and photothermal-responsive drug release behavior. These behaviors were observed at first in cellular experiments and will be further studied in vivo.
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| 今後の研究の推進方策 |
The next targets of the research are to correlate the drug uptake/release behaviors of the hybrid nanoparticles with theirs structures and characteristics. Furthermore, the efficacy of drug delivery will be tested in animal experiments.
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| 次年度使用額が生じた理由 |
In order to secure travel expenses for an invited lecture at an international conference held in USA (2020 December) and an oral talk in USA (2021 March), part of the FY2019 budget was transferred to FY2020.
In addition, the shared laser system, which will be used in later part of research plan, became unavailable due to the retirement of the related laboratory, so a part of the budget was transferred in order to obtain various components for a new laser system.
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