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2020 年度 実績報告書

植物炭疽病菌における強病原性菌株特異的遺伝子クラスターの進化と機能解明

研究課題

研究課題/領域番号 19K15846
研究機関国立研究開発法人理化学研究所

研究代表者

GAN PAMELA  国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (80634740)

研究期間 (年度) 2019-04-01 – 2021-03-31
キーワードGenome rearrangement / cluster / virulence / fungal genome / anthracnose / nudix / effector
研究実績の概要

Understanding how virulence emerges in pathogens can contribute to the development of better methods of disease control. We discovered a virulent strain-specific cluster of genes in Colletotrichum fungi which cause strawberry anthracnose that has an uneven phylogenetic distribution across multiple species. In FY2020, the following was achieved:

1. Submitted paper describing potential virulence gene clusters in sub-telomeric regions and repeat-rich chromosomes. The work and associated genome and transcriptome data has been publicly released on NCBI, github and Biorxiv and is currently under review in the journal Genome Research.

2. One of the proteins present in the potential virulence gene cluster, CfNudix, was characterized further. Phylogenetic analyses of all C. fructicola nudixes including CfNudix was carried out to determine the most closely related sequences to identify potential substrates by homology to previously characterized nudixes. The substrate specificity of purified CfNudix was tested on known nudix substrates.

  • 研究成果

    (1件)

すべて 2020

すべて 雑誌論文 (1件) (うち国際共著 1件、 査読あり 1件、 オープンアクセス 1件)

  • [雑誌論文] Subtelomeric regions and a repeat-rich chromosome harbor multicopy effector gene clusters with variable conservation in multiple plant pathogenic Colletotrichum species2020

    • 著者名/発表者名
      Pamela Gan, Ryoko Hiroyama, Ayako Tsushima, Sachiko Masuda, Arisa Shibata, Akiko Ueno, Naoyoshi Kumakura, Mari Narusaka, Trinh Xuan Hoat, Yoshihiro Narusaka, Yoshitaka Takano, Ken Shirasu
    • 雑誌名

      bio Rxiv

      巻: - ページ: -

    • DOI

      https://doi.org/10.1101/2020.04.28.061093

    • 査読あり / オープンアクセス / 国際共著

URL: 

公開日: 2021-12-27  

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