| 研究実績の概要 |
Following on from FY2020 where the selective serotonin re-uptake inhibitor (SSRI), paroxetine, was shown to significantly improve right ventricle systolic function and right ventricle-pulmonary artery coupling in a rat model of severe pulmonary hypertension (PH), the molecular mechanisms underlying this improvement were investigated.
It was shown the paroxetine treatment in PH rats was associated with ~80% higher myosin light chain-2 phosphorylation and significantly increased titin phosphorylation compared to the vehicle-treated PH rats. The changes in titin phosphorylated correlated with increased RV function.
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