| 研究課題/領域番号 |
19K16587
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| 研究機関 | 長崎大学 |
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研究代表者 |
ムサジャノワ ジャンナ 長崎大学, 原爆後障害医療研究所, 助教 (30770432)
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| 研究期間 (年度) |
2019-04-01 – 2022-03-31
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| キーワード | PTC / FFPE |
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| 研究実績の概要 |
We have already collected 160 cases of FFPE PTC tissue of Japanese patients and 250 cases of Kazakh patients. All cases were evaluated for BRAF mutation, TERT promoter C228T and C250T mutations, and Ki-67 labeling index. Now detailed analysis of histology and collection of samples are continuing. For instance, BRAFV600E is reported to find in 82% of Japan and 67% of Kazakh population, and TERT promoter in 25% of Japan and 5% of Kazakh population. Associations between BRAFV600E mutation with TERT promoter, and Ki-67 LI, and clinicopathologic factors will be presented to further.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
We have already collected 160 cases of FFPE PTC tissue of Japanese patients and 250 cases of Kazakh patients. All cases were evaluated for BRAF mutation, TERT promoter C228T and C250T mutations, and Ki-67 labeling index. Now detailed analysis of histology and collection of samples are continuing. For instance, BRAFV600E is reported to find in 82% of Japan and 67% of Kazakh population, and TERT promoter in 25% of Japan and 5% of Kazakh population.
Associations between BRAFV600E mutation with TERT promoter, and Ki-67 LI, and clinicopathologic factors will be presented to further.
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| 今後の研究の推進方策 |
We continuing collecting of cases of FFPE PTC tissue of Japanese patients and Kazakh patients. And planning to evaluate for BRAF mutation, TERT promoter C228T and C250T mutations, and Ki-67 labeling index. Now detailed analysis of histology and collection of samples are continuing. And last statistical analysis of associations between BRAFV600E mutation with TERT promoter, and Ki-67 LI, and clinicopathologic factors will be performed.
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