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2020 年度 実施状況報告書

分子異常をエビデンスとした高リスク乳頭がんの形態学的形質分析

研究課題

研究課題/領域番号 19K16587
研究機関長崎大学

研究代表者

ムサジャノワ ジャンナ  長崎大学, 原爆後障害医療研究所, 助教 (30770432)

研究期間 (年度) 2019-04-01 – 2022-03-31
キーワードPapillary carcinoma / TERT mutation / BRAF mutation
研究実績の概要

The 400 surgically-resected, formalin-fixed, paraffin-embedded (FFPE) thyroid FTs including 100 Japanese from one single hospital of Japan and 300 Kazakh cases from two hospital of Kazakhstan, were collected in this time. All Japanese cases and Kazakh cases were preliminary evaluated for BRAF, TERT and Ki-67. The coexistence of the two mutations was more strongly associated with high Ki-67 labeling index (>5 and >10%). Age of this patients range from 45 to 84 y.o. (mean age 68.52). In the 2017 new WHO classification was introduced and this classification brought significant changes in TNM grade and staging system of thyroid tumors. Thus, we performing re-classification of all available for our research cases.

現在までの達成度 (区分)
現在までの達成度 (区分)

3: やや遅れている

理由

We need perform re-classification of all cases by new WHO (2017) classification. For that we need review all HE staining of cases. Thus, we delay with study results.

今後の研究の推進方策

We request HE staining from Hospitals and reviewing them. Only 1/3 of cases are finished with re-classification.

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公開日: 2021-12-27  

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