| 研究実績の概要 |
This study aimed at assessing the the specific proteins that are targets of naturally acquired immunity against Plasmodium falciparum clinical malaria in individuals residing in a malaria endemic region in Uganda. In the initial analysis, we observed that > 98% of assayed proteins (n=265) were immunogenic in malaria-exposed individuals in Uganda. The overall breadth of immune responses was significantly correlated with age but not with clinical malaria outcome among the study volunteers. Children with high levels of antibodies to four RIFINs a STEVOR, and SURFIN 1.2 displayed reduced the risk of developing clinical malaria. This antigens are potential targets of protective immunity and need further investigation. Manuscript based on this data < Global repertoire of human antibodies against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a malaria exposed population> has just been accepted for publication in Frontiers in Immunology journal.
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| 今後の研究の推進方策 |
This study aims at contributing to malaria vaccine development studies aiming at developing vaccine based on the antigens that are targets of naturally acquired protective immunity.
therefore, in the next phase, analysis of specific Immunoglobulin G subclass will be considered to differentiate their role in protective immunity and identify other factors that are involved.
In addition, follow up studies targeting the selected RIFINs will be initiated to assess their mechanisms of action of the observed protective immunity.
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