| 研究実績の概要 |
This study aimed at assessing the the specific proteins that are targets of naturally acquired immunity against Plasmodium falciparum clinical malaria in individuals residing in a malaria endemic region in Uganda. In the initial phase, we observed that >98% of assayed proteins were immunogenic in malaria-exposed individuals in Uganda. Children with high levels of antibodies to four RIFINs a STEVOR, and SURFIN 1.2 displayed reduced the risk of developing clinical malaria. Subsequently, we observed that antibodies to a potential vaccine antigen, PF3D7_0801000 which localizes in merozoites, inhibit P. falciparum parasite growth in in vitro culture. The protein is strongly immunoreactive with serum obtained from a malaria-exposed Ugandan population, with antibody acquisition increasing with age. The selected proteins need further evaluation as asexual blood-stage vaccine candidate antigens. These and other findings were summarized in Kanoi et al (2021). Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development. Parasitol Int 80, 102224, doi:10.1016/j.parint.2020.102224.
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