| 研究課題/領域番号 |
19K16661
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
CHEUNG Martin 沖縄科学技術大学院大学, 量子波光学顕微鏡ユニット, 研究員 (90832163)
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| 研究期間 (年度) |
2019-04-01 – 2022-03-31
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| キーワード | Shigella flexneri / T3SS / Infection |
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| 研究実績の概要 |
Successfully completed the necessary experimental work as detailed in my Kakenhi project outline. Using cryo-EM and mass spectrometry, I was able to identify a hitherto unknown protein complex that binds to the tip of Shigella flexneri's type III secretion system (T3SS). I believe this complex to be crucial for the ability of the T3SS to sense target cells and for the activation of effector protein secretion through this system during the infective cycle. This finding not only ameliorates our understanding of the basic function and mechanism of the T3SS, but could serve as a target for therapeutics targeting this system.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
I have completed the experimental work and actually conducted even more experiments than I had planned. I am currently preparing a manuscript for submission to a peer-review journal.
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| 今後の研究の推進方策 |
Once my paper is submitted, I will work on addressing any concerns and comments from the reviewers. This could require conducting additional experiments.
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| 次年度使用額が生じた理由 |
Next year, I will use the remaining funds for manuscript publication in a peer-reviewed journal and for attending conferences to present my work.
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