| 研究実績の概要 |
Germinal center (GC)-associated nuclear protein (GANP) is critical molecule for the regulation of adaptive immune system. We investigated mRNAs and proteins associated with GANP in B cells. GANP interacts with many kinds of RNAs for various functions of cancer development, cell cycling, DNA repair, and protein translation. GANP interacts with the translation initiation factor eIF4E and efficiently targets the transcription factor c-Myc mRNA. Furthermore, GANP regulates c-Myc translation via interacting with the 5’ untranslated region of c-Myc mRNA in B cells. The results indicated that GANP is necessary for the upregulation of c-Myc in B cells undergoing the selection process in the GCs. The augmented c-Myc expression by GANP is likely a regulatory signal for B cell positive selection.
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