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2019 年度 実施状況報告書

A Comprehensive Theoretical Survey on Functionalities and Properties of Adult Neurogenesis under the Influence of Slow Oscillations

研究課題

研究課題/領域番号 19K16885
研究機関沖縄科学技術大学院大学

研究代表者

Fung ChiChung  沖縄科学技術大学院大学, 神経情報・脳計算ユニット, 研究員 (80757203)

研究期間 (年度) 2019-04-01 – 2023-03-31
キーワードAdult Neurogenesis / Pattern Separation / Detate Gyrus
研究実績の概要

In the last year, the principal investigator (PI) has engaged in the proposed research as well as the related researches collaborated with collaborators.

In the proposed research, the proposed neurogenesis model is implemented according to previous works (including the PI's work and others' experimental works). In the current setting of the model, the dendrites of the newly born dentate gyrus (DG) neurons can perform dendritic competitions among each other. A simple scoring measure and an entropic measure were developed to compare different situations. Also, the model is now capable to perform some of the desirable properties, e.g. memorizing assigned patterns. However, there are still some investigations needed to clarify the function of the model.

Besides the main research work, the principal investigator has also engaged in other related collaborations. The principal investigator has jointly proposed a model on long-term plasticity, which is closely related to memory formation. Also, to maximize the utilization of the purchased facility, the principal investigator has implemented his data analysis program to a GPU variant. This variant should be able to accelerate the analysis throughput.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

The progress of the project is fairly on the course. The principal investigator has fixed the model and developed the measure for model comparison as planned.

今後の研究の推進方策

In the coming year, the principal investigator will fine-tune the model to match the know experimental results. It will be an important step to enable comparison with the experiment and provide experimentally testable results. The principal investigator will also make a variant that is machine-learning-orientated. It is also an important change to make the model applicable to real-world data.

次年度使用額が生じた理由

The incurring amount will be used for attending conference in Japan and Other countries.

  • 研究成果

    (1件)

すべて 2019

すべて 雑誌論文 (1件) (うち査読あり 1件、 オープンアクセス 1件)

  • [雑誌論文] Orchestrated ensemble activities constitute a hippocampal memory engram2019

    • 著者名/発表者名
      Ghandour Khaled、Ohkawa Noriaki、Fung Chi Chung Alan、Asai Hirotaka、Saitoh Yoshito、Takekawa Takashi、Okubo-Suzuki Reiko、Soya Shingo、Nishizono Hirofumi、Matsuo Mina、Osanai Makoto、Sato Masaaki、Ohkura Masamichi、Nakai Junichi、Hayashi Yasunori、Sakurai Takeshi、Kitamura Takashi、Fukai Tomoki、Inokuchi Kaoru
    • 雑誌名

      Nature Communications

      巻: 10 ページ: 2637

    • DOI

      10.1038/s41467-019-10683-2

    • 査読あり / オープンアクセス

URL: 

公開日: 2021-01-27  

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