| 研究課題/領域番号 |
19K16892
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| 研究機関 | 富山大学 |
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研究代表者 |
アブドゥ カリーム 富山大学, 学術研究部医学系, 助教 (00833609)
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| 研究期間 (年度) |
2019-04-01 – 2021-03-31
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| キーワード | Inference |
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| 研究実績の概要 |
In order to unveil how our brain uses the existing knowledge during sleep to generate new information and hence understand the mechanism of creativity, I successfully established the sleep-dependent transitive inference behavior paradigm as a model for creative problem solving in which mice can infer correctly based on their previous experiences. Moreover, I identified the brain region (Anterior cingulate cortex, ACC) which is necessary for the emergence of the correct inference. Currently, I have got an interesting promising result in defining the brain circuit that is sufficient for the induction of artificial inference during sleep. In the near future, I will start investigating the neuronal dynamic mechanism of the emergence of inference during sleep by Ca2+ imaging technique.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
My progress is going well according to my plan. Establishing the behavior paradigm was the longest step because it needs trouble shooting and repeating the training for mice. The subsequent experiments were running well because I am working with my full power and capabilities.
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| 今後の研究の推進方策 |
My future plan is to investigate the neuronal dynamic mechanism of the emergence of inference during sleep by Ca2+ imaging technique. I will extract the ensembles (activity patterns) corresponding to the inference and their temporal dynamics to dissect the mechanism by which the inference information is emerged. Then, I will establish the causal link between the emerged ensembles during sleep and the inference performance by combining ultra-thin Fluorescence Endoscope Imaging System (U-FEIS) with multi-independent light stimulation system (MILSS).
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| 次年度使用額が生じた理由 |
In the first year, I purchased the majority of items that I need in my research study by the grant money. However, to make the maximum benefit from the items purchased, I sometimes use common materials in our lab purchased by my professor grant instead of buying them again, that’s the reason why there is remaining money from first year. I would like to use the remaining money in the second year because I need to buy more antibodies and cannulas for surgery in mice brain. Also, I need to order analysis software programs to accelerate my data analysis
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