| 研究課題/領域番号 |
19K20668
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| 研究機関 | 名古屋工業大学 |
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研究代表者 |
ゴメスタメス ホセデビツト 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (60772902)
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| 研究期間 (年度) |
2019-04-01 – 2022-03-31
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| キーワード | Brain stimulation / TMS / Multiscale modeling / Electric field / Nerve Modelling / Electroceuticals |
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| 研究実績の概要 |
Transcranial magnetic stimulation (TMS) induces a neurostimulation dosage (i.e., electric field) in the brain via a magnetic coil placed over the scalp. A multiscale electrophysiological model was developed to describe how TMS-induced dosage interacts with the activation of brain circuits in the human cortex.
By using the proposed computational approach, this study investigated the induced electric field effects on large pyramidal brain neurons. Also, the stimulation intensity thresholds for activation were identified. The model was used to investigate the conservativeness of safety limits in international safety guidelines/standards for electromagnetic exposure. The results have practical implications in clinical practice for optimized brain stimulation and understanding TMS mechanism.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Most of the contents described in the plan were achieved.
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| 今後の研究の推進方策 |
In FY2020, experiments of TMS physiological responses will be conducted to validate and improve the multiscale electrophysiological model. TMS-induced currents in the human motor cortex can target specific brain circuits according to the stimulation conditions that can generate different responses. The model developed will be used to determine neuronal responses using the same experimental setup (coil position/orientation and stimulation strength) and a realistic head model of the subjects. For the first one, a navigation system will record the position/orientation of the coil. For the second one, magnetic resonance images of each subject will be obtained to construct individualized head models.
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