| 研究課題/領域番号 |
18H06103
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| 配分区分 | 補助金 |
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| 研究機関 | 大阪大学 |
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研究代表者 |
ZWAMA MARTIJN 大阪大学, 産業科学研究所, 特任助教(常勤) (40827052)
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| 研究期間 (年度) |
2018-08-24 – 2020-03-31
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| キーワード | RND / Transporter / Antibiotic / Resistance / AcrB / Evolution |
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| 研究実績の概要 |
Studied the evolution of multidrug efflux pumps (RND transporters), and observed the environmental adaption of these pump within specific organisms. The antibiotic and inhibitor specificities of an ancient RND transporter were identified. In this fiscal year FY2018 we could publish (and submit) one review article and one research article.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The experiments and results were performed very efficiently, by a relatively fast data output and interesting and revealing data, which brought significant new insights in the evolution of multidrug efflux transporters of the RND superfamily. One review article and one research article on this research within one fiscal year was achieved.
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| 今後の研究の推進方策 |
Studying more RND multidrug efflux transporters and also analyze drug resistance in different bacterial strains.
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