The roles of basolateral amygdala in regulation of optimism and pessimism

2021 年度 実績報告書

• 研究課題/領域番号: 19K21807
• 研究機関: 筑波大学
• 研究代表者: 張 王其 筑波大学, 人間系, 助教 (20525604)
• 研究期間 (年度): 2019-06-28 – 2022-03-31
• キーワード: optimism and pessimism / neural circuit / basolateral amygdala / calcium imaging / fiber photometry

研究実績の概要

In this fiscal year, we successfully labelled BLA cells with calcium indicators and set up fiber photometry system. We recorded the activity dynamics of multiple populations of cells in basolateral amygdala during each step of ambiguous tone test. And we found that different BLA populations experienced distinct dynamics during the test. The data suggest that different populations of BLA cells regulate the direction of cognitive bias in different ways. We could publish 3 papers in international journals, and present our work in six international conferences.

研究成果

• [雑誌論文] On the origins of social behavior diversity. (2021)
  • 著者名/発表者名: Larry Young, Qi Zhang
  • 雑誌名: The Japanese Journal of Animal Psychology 巻: 1 ページ: 1
  • DOI: 10.2502/janip.71.1.4
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid - induced seizures in neuronal GPI anchor deficiency mouse models. (2021)
  • 著者名/発表者名: Kandasamy L, Tsukamoto M, Banov V, Tsetsegee S, Nagasawa Y, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young L, Zhang Q
  • 雑誌名: Human Molecular Genetics 巻: 30(9) ページ: 758-770
  • DOI: 10.1093/hmg/ddab052
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] The hippocampus encodes delay and value information during delay-discounting decision making. (2021)
  • 著者名/発表者名: Masuda A, Sano C, Zhang Q, Goto H, McHugh T, Fujisawa S, Itohara S.
  • 雑誌名: Elife 巻: 9 ページ: 52466
  • DOI: 10.7554/eLife.52466.
  • 査読あり / オープンアクセス / 国際共著
• [学会発表] Oxytocin receptor and the diversity in social behaviors. (2021)
  • 著者名/発表者名: Qi Zhang
  • 学会等名: The Social Brain Symposium 2.0: Social Neuroscience in the Post Pandemic Era, Tsukuba Conference 2021
  • 国際学会 / 招待講演
• [学会発表] On the origin of diversity in social behavior. (2021)
  • 著者名/発表者名: Qi Zhang
  • 学会等名: East/South East Asia Social Brain Symposium
  • 国際学会 / 招待講演
• [学会発表] Inhibitory neurons play key roles in mediating multiple phenotypes in a mouse model of inherited glycosylphosphatidylinositol deficiency disease. (2021)
  • 著者名/発表者名: Qi Zhang
  • 学会等名: The 15th International Conference on Genetic Disorders and Gene Therapy
  • 国際学会 / 招待講演
• [学会発表] Toward creating a mouse loyal to its partner. (2021)
  • 著者名/発表者名: Qi Zhang
  • 学会等名: The Annual Meeting of Japan Neuroscience Society
  • 国際学会 / 招待講演
• [学会発表] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models. (2021)
  • 著者名/発表者名: Kandasamy LC, Zhang Q
  • 学会等名: The 44th Annual Meeting of Japan Neuroscience Society
  • 国際学会 / 招待講演
• [学会発表] The trait-like differences in cognitive bias in outbred CD-1 mice. (2021)
  • 著者名/発表者名: Tsetsegee S, Zhang Q
  • 学会等名: The 44th Annual Meeting of Japan Neuroscience Society
  • 国際学会 / 招待講演
• [備考] lab webpage
  • URL: https://www.qizhanglab.com/
• [学会・シンポジウム開催] The 44th Annual Meeting of Japan Neuroscience Society (2021)