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2020 年度 実施状況報告書

Brain-controlled neuroprosthetic for restoration of upper-limb function

研究課題

研究課題/領域番号 19K23606
研究機関大阪大学

研究代表者

MILOSEVIC MATIJA  大阪大学, 基礎工学研究科, 助教 (50840188)

研究期間 (年度) 2019-08-30 – 2022-03-31
キーワードbrain-computer interface / neuroprosthetics / upper-limb / rehabilitation / neuroplasticity
研究実績の概要

The objectives of this research are to develop: (1) a brain-computer interface (BCI) system that can detect hand opening / closing movements using non-invasive cortical (brain) signals from human participants during motor imagery tasks, and (2) a neuroprosthetic technology that can activate the upper-limb muscles through functional electrical stimulation (FES). Finally, the research program aims to test the feasibility of this BCI-controlled FES neuroprosthetic and examine how it can contribute to restoration of upper-limb motor function. Based on these objectives, we have developed and implemented a BCI-controlled FES system and proposed the underlying mechanisms of recovery of upper-limb motor function that can be elicited through BCI-controlled FES. We showed that presynaptic cortical facilitation followed by postsynaptic FES (BCI-controlled FES) is required to elicit short-term corticospinal facilitation, while only postsynaptic FES (random FES) activation was ineffective. Moreover, we have been testing how FES can be used to activate different muscles and as such facilitate excitability of the central nervous system. Specifically, it was shown that long-term application of upper-limb FES can facilitate cortical excitability beyond the training period. In summary, a BCI-FES system with an accuracy of ~85% was developed, and it was shown to contribute to restoration of upper-limb motor function through facilitation of cortical and peripheral activations.

現在までの達成度 (区分)
現在までの達成度 (区分)

1: 当初の計画以上に進展している

理由

(1) In the research related to the development of the BCI system, we have implemented and tested the BCI-FES system proved the underlying mechanisms of BCI-controlled FES for recovery of upper-limb function [1]. Specifically, motor imagery was shown to affect cortical networks [2]. Moreover, threshold-based motor imagery BCI was shown to work with an accuracy of ~85% [3], while a machine learning classifier had a comparable detection [4]. Notably, using the BCI-controlled FES system was shown as effective in facilitating corticospinal excitability more than random application of FES [3], confirming our results indicating that cortical facilitation before FES is necessary to elicit neural plasticity [5].

(2) In the research related to the development of FES technology, we have been testing how FES can activate muscles and the central nervous system. Specifically, we showed that upper-limb FES can elicit considerable and long-lasting cortical re-organization [6]. A book chapter is currently in preparation based on these findings for a textbook titled Neurorehabilitation Technology edited by Dr. Volker Dietz.

References: [1] M. Milosevic, et al., BioMedical Engineering Online, vol. 19, 81, 2020; [2] Y. Suzuki, et al., Neuroscience Letters, vol. 755, 2021; [3] Y. Suzuki, et al., To be submitted to Neuromodulation; [4] Y. Yamanouchi, et al., To be submitted to Artificial Organs; [5] N. Cao, et al., To be submitted to Brain Stimulation; [6] M. Milosevic, et al., medRxiv, 2020.

今後の研究の推進方策

In the future, we will complete all analyses of data that was collected during experiments in Osaka and Tokyo. Moreover, we will continue preparing manuscripts for dissemination of research results in international peer-reviewed journals and work towards publishing all the research findings.

次年度使用額が生じた理由

Travel implementation schedule for collaborative research at the University of Tokyo was adjusted due to restrictions related to COVID-19. Despite this, all BCI-FES experiments were conducted and completed at Osaka University. Moreover, experimental schedule at the University of Tokyo related to testing of FES technology were completed within the scheduled timelines with students belonging to the University of Tokyo. Currently, final data analysis and preparations for dissemination of research results in international journals is currently underway.

  • 研究成果

    (16件)

すべて 2021 2020 その他

すべて 国際共同研究 (1件) 雑誌論文 (9件) (うち国際共著 9件、 査読あり 8件、 オープンアクセス 4件) 学会発表 (6件) (うち国際学会 3件、 招待講演 3件)

  • [国際共同研究] University of Toronto/Toronto Rehabilitation Institute(カナダ)

    • 国名
      カナダ
    • 外国機関名
      University of Toronto/Toronto Rehabilitation Institute
  • [雑誌論文] Muscle-specific movement-phase-dependent modulation of corticospinal excitability during upper-limb motor execution and motor imagery combined with virtual action observation2021

    • 著者名/発表者名
      Yoshiyuki Suzuki, Naotsugu Kaneko, Atsushi Sasaki, FumiyaTanaka, Kimitaka Nakazawa, Taishin Nomura and Matija Milosevic
    • 雑誌名

      Neuroscience Letters

      巻: 755 ページ: -

    • DOI

      10.1016/j.neulet.2021.135907

    • 査読あり / 国際共著
  • [雑誌論文] Long-lasting event-related beta synchronizations of electroencephalographic activity in response to support-surface perturbations during upright stance: A pilot study associating beta rebound and active monitoring in the intermittent postural control2021

    • 著者名/発表者名
      Akihiro Nakamura, Yasuyuki Suzuki, Matija Milosevic and Taishin Nomura
    • 雑誌名

      Frontiers in Systems Neuroscience

      巻: - ページ: -

    • DOI

      10.3389/fnsys.2021.660434

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Contribution of Each Motor Point of Quadriceps Femoris to Knee Extension Torque During Neuromuscular Electrical Stimulation2021

    • 著者名/発表者名
      Derrick Lim, Mikael Del Castillo, Austin J Bergquist, Matija Milosevic and Kei Masani
    • 雑誌名

      IEEE Transactions on Neural Systems and Rehabilitation Engineering

      巻: 29 ページ: 389-396

    • DOI

      10.1109/TNSRE.2021.3052853

    • 査読あり / 国際共著
  • [雑誌論文] Why brain-controlled neuroprosthetics matter: Mechanisms underlying electrical stimulations of muscles and nerves in rehabilitation2020

    • 著者名/発表者名
      Matija Milosevic, Cesar Marquez-Chin, Kei Masani, Masayuki Hirata, Taishin Nomura, Milos R. Popovic and Kimitaka Nakazawa
    • 雑誌名

      BioMedical Engineering OnLine

      巻: 19, 81 ページ: -

    • DOI

      10.1186/s12938-020-00824-w

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Postural instability via a loss of intermittent control in elderly and patients with Parkinson’s disease: a model-based and data-driven approach for dynamical disease2020

    • 著者名/発表者名
      Yasuyuki Suzuki, Akihiro Nakamura, Matija Milosevic, Kunihiko Nomura, Takao Tanahashi, Takuyuki Endo, Saburo Sakoda, Pietro Morasso and Taishin Nomura
    • 雑誌名

      Chaos: Interdisciplinary Journal of Nonlinear Science

      巻: 30(11) ページ: 113140

    • DOI

      10.1063/5.0022319

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Cortical and subcortical neural interactions between trunk and upper-limb muscles in humans2020

    • 著者名/発表者名
      Atsushi Sasaki, Matija Milosevic and Kimitaka Nakazawa
    • 雑誌名

      Neuroscience

      巻: 451 ページ: 126-136

    • DOI

      10.1016/j.neuroscience.2020.10.011

    • 査読あり / 国際共著
  • [雑誌論文] Interlimb neural interactions in corticospinal and spinal reflex circuits during preparation and execution of isometric elbow flexion2020

    • 著者名/発表者名
      Atsushi Sasaki, Naotsugu Kaneko, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
    • 雑誌名

      Journal of Neurophysiology

      巻: 124(3) ページ: 652-667

    • DOI

      10.1152/jn.00705.2019

    • 査読あり / 国際共著
  • [雑誌論文] Changes in corticospinal excitability during bilateral and unilateral lower-limb force control tasks2020

    • 著者名/発表者名
      Akiko Yamaguchi, Atsushi Sasaki, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
    • 雑誌名

      Experimental Brain Research

      巻: 238(9) ページ: 1977-1987

    • DOI

      10.1007/s00221-020-05857-0

    • 査読あり / 国際共著
  • [雑誌論文] Cortical re-organization after traumatic brain injury elicited using functional electrical stimulation therapy: A case report2020

    • 著者名/発表者名
      Matija Milosevic, Tomoya Nakanishi, Atsushi Sasaki, Akiko Yamaguchi, Taishin Nomura, Milos R. Popovic and Kimitaka Nakazawa
    • 雑誌名

      medRxiv

      巻: - ページ: -

    • DOI

      10.1101/2020.05.31.20118323

    • オープンアクセス / 国際共著
  • [学会発表] Mechanisms of brain-controlled functional electrical stimulation of muscles in neurorehabilitation2021

    • 著者名/発表者名
      Matija Milosevic
    • 学会等名
      Webinar - International Functional Electrical Stimulation Society (IFESS)
    • 国際学会 / 招待講演
  • [学会発表] How brain-controlled electrical stimulation of muscles can be used to elicit neural plasticity2020

    • 著者名/発表者名
      Matija Milosevic
    • 学会等名
      Invited presentations at the Center for Information and Neural Networks (CiNet) - Osaka University
  • [学会発表] Development of an upper-limb virtual reality system for brain-computer interface2020

    • 著者名/発表者名
      Yoshiyuki Suzuki, Fumiya Tanaka, Matija Milosevic and Taishin Nomura
    • 学会等名
      ME and Bio Cybernetics Virtual Forum
  • [学会発表] Validation of the effectiveness of functional electric stimulation (FES) therapy by using fMRI and TMS: Interventional study on a traumatic brain injury patient2020

    • 著者名/発表者名
      Tomoya Nakanishi, Matija Milosevic, Atsushi Sasaki, Akiko Yamaguchi and Kimitaka Nakazawa
    • 学会等名
      Japanese Society for Brain Function and Rehabilitation
  • [学会発表] Neurophysiology of brain-machine interface rehabilitation2020

    • 著者名/発表者名
      Matija Milosevic
    • 学会等名
      42nd International Conference of the IEEE Engineering in Medicine and Biology Society
    • 国際学会 / 招待講演
  • [学会発表] Neural interactions between the trunk and the upper-limb muscles in humans: Effects of cortical and subcortical contributions2020

    • 著者名/発表者名
      Atsushi Sasaki, Matija Milosevic and Kimitaka Nakazawa
    • 学会等名
      13th FENS Forum
    • 国際学会 / 招待講演

URL: 

公開日: 2021-12-27  

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