研究課題
We have successfully performed the dissociation of the p53 core domain tetramers out of the complex with DNA. We found that the bending of DNA contributes largely to the dissociation of the core domain out of the tetramers. We have successfully carried out the C-terminal domain scanning of DNA and find key interaction that contributes to the binding. We developed the method to sample efficiently the slow domain motion of the protein using PCA analysis and Markov State Modeling. We successfully constructed the full length complex of A2a receptor bound to Gs protein. The structure is stable and we found the mechanism of signal transmission pathway in the A2a/Gs protein complex.
すべて 2021 2020
すべて 雑誌論文 (4件) (うち国際共著 3件、 査読あり 4件) 学会発表 (4件) (うち国際学会 3件、 招待講演 2件)
Cell
巻: 184 ページ: 1884~1894.e14
10.1016/j.cell.2021.02.041
The Journal of Chemical Physics
巻: 152 ページ: 225101~225101
10.1063/5.0004654
ACS Omega
巻: 5 ページ: 22847~22851
10.1021/acsomega.0c02088
アンサンブル : 分子シミュレーション研究会会誌
巻: 22 ページ: 151~156