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2021 年度 実績報告書

Incontinence-associated dermatitis by infected urine: biological mechanisms and prevention strategies

研究課題

研究課題/領域番号 19K24194
研究機関東京大学

研究代表者

KOUDOUNAS SOFOKLIS  東京大学, 大学院医学系研究科(医学部), 特任助教 (70849968)

研究期間 (年度) 2019-08-30 – 2022-03-31
キーワードIAD
研究実績の概要

My results last year showed that urine promotes the growth of bacteria. This year I successfully established an animal model of incontinence-associated dermatitis by the combination of urine and bacteria. After exposure for three days to urine and bacteria animals developed an IAD-like persistent redness, characterized by increased infiltration of inflammatory cells, skin barrier disruption and bacteria invasion to the epidermis. These findings have been presented at domestic and international conferences. For this research, I was awarded the Young Investigator Award by the Japanese society for Wound Healing.

  • 研究成果

    (4件)

すべて 2021

すべて 雑誌論文 (1件) 学会発表 (3件)

  • [雑誌論文] The inhibitory effect of artificial urine on proliferation and motility of Pseudomonas aeruginosa , Escherichia coli , Proteus mirabilis and Klebsiella pneumoniae changes to a promoting effect during culture.2021

    • 著者名/発表者名
      Sofoklis Koudounas , Takeo Minematsu , Yuko Mugida , Sanae Tomita , Ayano Nakai , Gojiro Nakagami and Hiromi Sanada
    • 雑誌名

      Journal of Nursing Science and Engineering

      巻: 8 ページ: 220-229

    • DOI

      10.24462/jnse.8.0_220

  • [学会発表] Development of a rat model for incontinence-associated dermatitis in patients with urinary infections2021

    • 著者名/発表者名
      Sofoklis Koudounas, Takeo Minematsu, Yuko Mugita, Gojiro Nakagami and Hiromi Sanada
    • 学会等名
      ‘Beyond Borders’-The 51st Annual Meeting of Japanese Society for Wound Healing
  • [学会発表] Development of a rat model for incontinence-associated dermatitis in patients with urinary-infections2021

    • 著者名/発表者名
      Koudounas S, Minematsu T, Mugita Y, Nakagami G, Sanada H
    • 学会等名
      The 9th Asia Pacific Enterostomal Therapy Nurse Association Conference
  • [学会発表] Does the presence of bacterial urinary infection contribute to the development of incontinence-associated dermatitis? A scoping review2021

    • 著者名/発表者名
      Koudounas S, Mugita Y, Minematsu T, Nakagami G, Weller C, Sanada H
    • 学会等名
      The 9th Asia Pacific Enterostomal Therapy Nurse Association Conference

URL: 

公開日: 2022-12-28  

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