抗加齢ドック受診者を対象とした循環器疾患の発症に関する 長期縦断疫学研究

2012 年度 研究成果報告書

• 研究課題/領域番号: 20390185
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 公衆衛生学・健康科学
• 研究機関: 京都大学 (2012); 愛媛大学 (2008-2011)
• 研究代表者: 田原 康玄 京都大学, 大学院・医学研究科, 准教授 (00268749)
• 研究分担者: 三木 哲郎 愛媛大学, プロテオ医学研究センター, 教授 (00174003) ; 小原 克彦 愛媛大学, 大学院・医学系研究科, 准教授 (30260384) ; 大澤 春彦 愛媛大学, 大学院・医学系研究科, 教授 (90294800)
• 研究期間 (年度): 2008 – 2012
• キーワード: 動脈硬化 / 長期縦断疫学研究 / ゲノム / 動脈硬化性疾患

研究概要

動脈硬化性疾患とその関連因子の関係を包括的に理解する目的で、人間ドック受診者を対象としたコホート研究を行った。内臓脂肪蓄積、インスリン抵抗性、動脈硬化、サルコペニア、無症候性脳血管障害、認知機能ならびに遺伝子多型について、研究成果に示したような相関関係を明らかにした。

研究成果

• [雑誌論文] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia. (2013)
  • 著者名/発表者名: Nakayama K, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S
  • 雑誌名: Hum Genet ページ: 201-217
  • DOI: doi:10.1007/s00439-012-1240-9.
• [雑誌論文] Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J-SHIPP study (2013)
  • 著者名/発表者名: Tabara Y, Igase M, Okada Y, Nagai T, Uetani E, Kido T, Ochi N, Takita R, Yamamoto M, Kohara K, Miki T
  • 雑誌名: Eur J Neurol 巻: 20 ページ: 860-882
  • DOI: doi:10.1111/j.1468-1331.2012.03879.x.
• [雑誌論文] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study (2012)
  • 著者名/発表者名: Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T
  • 雑誌名: Clin Hemorheol Microcirc
  • DOI: doi:10.3233/CH-2012-1634
• [雑誌論文] Atherosclerotic indices for the prediction of cognitive impairment in a middle-aged to elderly general population: shimanami health promoting program study (2012)
  • 著者名/発表者名: Kohara K, Igase M, Tabara Y, Miki T
  • 雑誌名: J Am Geriatr Soc 巻: 60 ページ: 1996-1997
  • DOI: doi:10.1111/j.1532-5415.2012.04184.x.
• [雑誌論文] Postprandial hypertension, an overlooked risk marker for arteriosclerosis (2012)
  • 著者名/発表者名: Uetani E, Tabara Y, Igase M, Guo H, Kido T, Ochi N, Takita R, Kohara K, Miki T
  • 雑誌名: Atherosclerosis. 巻: 224 ページ: 500-505
  • DOI: doi:10.1016/j.atherosclerosis.2012.07.015.
• [雑誌論文] A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval (2012)
  • 著者名/発表者名: Kim JW, Hong KW, Go MJ, Kim SS, Tabara Y, Kita Y, Tanigawa T, Cho YS, Han BG, Oh B
  • 雑誌名: Am J Hum Genet 巻: 91 ページ: 180-184
  • DOI: doi:10.1016/j.ajhg.2012.05.019.
• [雑誌論文] Liver enzyme and adipocytokine profiles are synergistically associated with insulin resistance: the J-SHIPP study (2012)
  • 著者名/発表者名: Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Takita R, Kohara K, Miki T.
  • 雑誌名: J Atheroscler Thromb 巻: 19 ページ: 577-584
  • DOI: doi:10.5551/jat.11924
• [雑誌論文] Potential utility of soluble p3-alcadeinα plasma levels as a biomarker for sporadic Alzheimer's disease (2012)
  • 著者名/発表者名: Kamogawa K, Kohara K, Tabara Y, Takita R, Miki T, Konno T, Hata S, Suzuki T
  • 雑誌名: J Alzheimers Dis 巻: 31 ページ: 421-8
  • DOI: doi:10.3233/JAD-2012-120601.
• [雑誌論文] Arterial stiffness in sarcopenic visceral obesity in the elderly: J-SHIPP study (2012)
  • 著者名/発表者名: Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T
  • 雑誌名: Int J Cardiol 巻: 158 ページ: 146-148
  • DOI: doi:10.1016/j.ijcard.2012.04.033
• [雑誌論文] Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects: J-SHIPP study (2012)
  • 著者名/発表者名: Kido M, Kohara K, Miyawaki S, Tabara Y, Igase M, Miki T
  • 雑誌名: Geriatr Gerontol Int 巻: 12 ページ: 733-740
  • DOI: doi:10.1111/j.1447-0594.2011.00824.x.
• [雑誌論文] Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes (2011)
  • 著者名/発表者名: Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T
  • 雑誌名: PLoS One 巻: 6 ページ: e24633
  • DOI: doi:10.1371/journal.pone.0024633
• [雑誌論文] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance (2011)
  • 著者名/発表者名: Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Ta
  • 雑誌名: Cell Metab 巻: 14 ページ: 231-241
  • DOI: doi:10.1016/j.cmet.2011.05.011
• [雑誌論文] International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk (2011)
  • 雑誌名: Nature. 巻: 478 ページ: 103-109
  • DOI: doi:10.1038/nature10405.
• [雑誌論文] Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians (2011)
  • 著者名/発表者名: Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson
  • 雑誌名: Nat Genet 巻: 43 ページ: 531-538
  • DOI: doi:10.1038/ng.834
• [雑誌論文] Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score (2011)
  • 著者名/発表者名: Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Makino H, Kohara K, Miki T
  • 雑誌名: Metabolism 巻: 60(11) ページ: 1634-40
  • DOI: doi:10.1016/j.metabol.2011.03.014
• [雑誌論文] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study (2011)
  • 著者名/発表者名: Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
  • 雑誌名: J Hypertens 巻: 29 ページ: 1948-54
  • DOI: doi:10.1097/HJH.0b013e32834abd06
• [雑誌論文] Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study (2010)
  • 著者名/発表者名: Kamogawa K, Kohara K, Tabara Y, Uetani E, Nagai T, Yamamoto M, Igase M, Miki T
  • 雑誌名: Dement Geriatr Cogn Disord 巻: 30 ページ: 432-9
  • DOI: doi:10.1159/000321985
• [雑誌論文] Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project. (2010)
  • 著者名/発表者名: Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K
  • 雑誌名: Hypertension. 巻: 56 ページ: 973-980
  • DOI: doi:10.1161/HYPERTENSIONAHA.110.153429
• [雑誌論文] Association of four genetic loci with uric acid levels and reduced renal function: the J-SHIPP Suita study (2010)
  • 著者名/発表者名: Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T
  • 雑誌名: Am J Nephrol 巻: 32 ページ: 279-286
  • DOI: doi:10.1159/000318943
• [雑誌論文] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population (2010)
  • 著者名/発表者名: Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H
  • 雑誌名: J Hum Genet 巻: 55 ページ: 600-604
  • DOI: doi:10.1038/jhg.2010.75
• [雑誌論文] Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men (2010)
  • 著者名/発表者名: Ochi M, Kohara K, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T.
  • 雑誌名: Atherosclerosis. 巻: 212 ページ: 327-332
  • DOI: doi:10.1016/j.atherosclerosis.2010.05.026
• [雑誌論文] Postural instability is associated with brain atrophy and cognitive impairment in the elderly: the J-SHIPP study (2010)
  • 著者名/発表者名: Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K
  • 雑誌名: Dement Geriatr Cogn Disord 巻: 29 ページ: 379-387
  • DOI: doi:10.1159/000255106
• [雑誌論文] A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population (2010)
  • 著者名/発表者名: Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H
  • 雑誌名: PLoS One 巻: 5 ページ: e9718
  • DOI: doi:10.1371/journal.pone.0009718
• [雑誌論文] Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population (2010)
  • 著者名/発表者名: Ochi M, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T, Kohara K
  • 雑誌名: Geriatr Gerontol Int 巻: 10 ページ: 233-243
  • DOI: doi:10.1111/j.1447-0594.2010.00610.x
• [雑誌論文] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population? (2010)
  • 著者名/発表者名: Osawa H, Tabara Y, Ohashi J, Kawamura R, Onuma H, Makino H
  • 雑誌名: Diabetologia. 巻: 53 ページ: 795-797
  • DOI: doi:10.1007/s00125-010-1665-4
• [雑誌論文] Associations between short one-leg standing time and speed of sound of calcaneal bone in a general population: the Shimanami Health Promoting Program (J-SHIPP) study (2010)
  • 著者名/発表者名: Kido T, Tabara Y, Igase M, Uetani E, Ochi N, Miki T, Kohara K
  • 雑誌名: Geriatr Gerontol Int 巻: 10 ページ: 138-144
  • DOI: doi:10.1111/j.1447-0594.2009.00565.x
• [雑誌論文] Association of central systolic blood pressure with intracerebral small vessel disease in Japanese (2010)
  • 著者名/発表者名: Ochi N, Kohara K, Tabara Y, Nagai T, Kido T, Uetani E, Ochi M, Igase M, Miki T
  • 雑誌名: Am J Hypertens 巻: 23 ページ: 889-894
  • DOI: doi:10.1038/ajh.2010.60
• [雑誌論文] Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients (2010)
  • 著者名/発表者名: Miyashita H, Aizawa A, Hashimoto J, Hirooka Y, Imai Y, Kawano Y, Kohara K, Sunagawa K, Suzuki H, Tabara Y, Takazawa K, Takenaka T, Yasuda H, Shimada K
  • 雑誌名: Am J Hypertens 巻: 23 ページ: 260-268
  • DOI: doi:10.1038/ajh.2009.255
• [雑誌論文] Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study (2010)
  • 著者名/発表者名: Guo H, Tabara Y, Igase M, Yamamoto M, Ochi N, Kido T, Uetani E, Taguchi K, Miki T, Kohara K
  • 雑誌名: Hypertens Res 巻: 33 ページ: 32-36
  • DOI: doi:10.1038/hr.2009.172
• [雑誌論文] Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject (2009)
  • 著者名/発表者名: Ochi N, Tabara Y, Igase M, Nagai T, Kido T, Miki T, Kohara K
  • 雑誌名: Hypertens Res 巻: 32 ページ: 255-260
  • DOI: doi:10.1038/hr.2009.13
• [雑誌論文] Asymptomatic cerebral microbleeds seen in healthy subjects have a strong association with asymptomatic lacunar infarction (2009)
  • 著者名/発表者名: Igase M, Tabara Y, Igase K, Nagai T, Ochi N, Kido T, Nakura J, Sadamoto K, Kohara K, Miki T
  • 雑誌名: Circ J 巻: 73(3) ページ: 530-3
• [雑誌論文] No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population (2008)
  • 著者名/発表者名: Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, Kohara K
  • 雑誌名: Obesity 巻: 16 ページ: 211-215
  • DOI: doi:10.1038/oby.2007.25
• [雑誌論文] Resistin, glomerular filtration rate, and insulin resistance (2008)
  • 著者名/発表者名: Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K
  • 雑誌名: Hypertension 巻: 51 ページ: e11
  • DOI: doi:10.1161/HYPERTENSIONAHA.107.102046
• [雑誌論文] Blood pressure is the main determinant of the reflection wave in patients with type 2 diabetes (2008)
  • 著者名/発表者名: Tomita H, Kawamoto R, Tabara Y, Miki T, Kohara K
  • 雑誌名: Hypertens Res 巻: 31 ページ: 493-499
  • DOI: doi:10.1291/hypres.31.493
• [雑誌論文] Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population: the Shimanami Health Promoting Program Study (2008)
  • 著者名/発表者名: Tabara Y, Osawa H, Kawamoto R, Tachibana-Iimori R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K
  • 雑誌名: J Clin Endocrinol Metab 巻: 93 ページ: 715-722
  • DOI: doi:10.1210/jc.2007-0397
• [学会発表] Postprandial hypertension; an overlooked risk factor for arterial stiffness (2011)
  • 著者名/発表者名: Uetani E, Tabara Y, Igase M, Ochi N, Kido T, Miki T, Kohara K
  • 学会等名: Council for High Blood Pressure Research
  • 発表場所: Orlando
  • 年月日: 20110920-24
• [学会発表] Relatively lower central aortic pressure in subjects with impaired insulin sensitivity and resistance: The Toon Health Study (2011)
  • 著者名/発表者名: Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
  • 学会等名: Council for High Blood Pressure Research
  • 発表場所: Orlando
  • 年月日: 20110920-24
• [学会発表] Reduced lower extremity muscle mass is an independent risk factor for incidence of falls (2011)
  • 著者名/発表者名: Tabara Y, Igase M, Uetani E, Kido T, Ochi N, Kohara K, Miki T
  • 学会等名: International Conference on Sarcopenia Research
  • 発表場所: Toulouse.
  • 年月日: 20110616-19
• [学会発表] Postprandial hypotension as a risk factor for cognitive decline in community-dwelling elderly persons (2010)
  • 著者名/発表者名: Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Yamamoto M, Kohara K, Miki T
  • 学会等名: 23rd Scientific Meeting, The International Society of Hypertension
  • 発表場所: Vancouver
  • 年月日: 20100926-30
• [学会発表] Class effects of BP-lowering drugs on central blood pressure measurement (2010)
  • 著者名/発表者名: Uetani E, Tabara Y, Igase M, Ochi N, Kido T, Kohara K, Miki T
  • 学会等名: 23rd Scientific Meeting, The International Society of Hypertension
  • 発表場所: Vancouver
  • 年月日: 20100926-30
• [学会発表] Postprandial hypotension is associated with asymptomatic cerebrovascular damage in community-dwelling elderly (2009)
  • 著者名/発表者名: Tabara Y, Igase M, Nagai T, Kido T, Ochi N, Uetani E, Miki T, Kohara K
  • 学会等名: XIXth IAGG World Congress of Gerontology and Geriatrics
  • 発表場所: Paris
  • 年月日: 20090705-09
• [学会発表] Postural instability is-associated with brain atrophy and cognitive impairment in elderly: the J-SHIPP study (2009)
  • 著者名/発表者名: Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K
  • 学会等名: XIXth IAGG World Congress of Gerontology and Geriatrics
  • 発表場所: Paris
  • 年月日: 20090705-09
• [学会発表] Nocturnal blood pressure and mild cognitive impairment in elderly (2008)
  • 著者名/発表者名: Tabara Y, Igase M, Yamamoto M, Nakura J, Ochi N, Kido T, Miki T, Kohara K
  • 学会等名: 62nd Council for High Blood Pressure Research
  • 発表場所: Atlanta
  • 年月日: 20080917-20
• [学会発表] Urate anion exchanger gene, SLC22A12, polymorphism is associated with plasma uric acid levels but not inflammation and insulin resistance (2008)
  • 著者名/発表者名: Tabara Y, Kawamoto R, Tachibana-Iimori R, Yamamoto M, Miki T, Kohara K
  • 学会等名: 22nd Scientific Meeting, the International Society of Hypertension
  • 発表場所: Berlin
  • 年月日: 20080714-19
• [学会発表] Plasma leptin levels and orthostatic hypertension in the elderly (2008)
  • 著者名/発表者名: Tabara Y, Igase M, Tomoko K, Namiko O, Tetsuro M, Kohara K
  • 学会等名: 22nd Scientific Meeting, the International Society of Hypertension
  • 発表場所: Berlin
  • 年月日: 20080714-19
• [学会発表] Composition of the lower extremity in relation to a high ankle-brachial index: The J-SHIPP study (2008)
  • 著者名/発表者名: Tabara Y, Igase M, Kido T, Ochi N, Miki T, Kohara K
  • 学会等名: 22nd Scientific Meeting, the International Society of Hypertension
  • 発表場所: Berlin
  • 年月日: 20080714-19
• [学会発表] Orthostatic decline in augmentation index and late systolic blood pressure is a risk factor for silent lacunar infarction (2008)
  • 著者名/発表者名: Tabara Y, Igase M, Nagai T, Kido T, Ochi N, Tetsuro M, Kohara K
  • 学会等名: 22nd Scientific Meeting, the International Society of Hypertension
  • 発表場所: Berlin
  • 年月日: 20080714-19