副甲状腺細胞内における副甲状腺ホルモン断片化調節機構の研究

2010 年度 研究成果報告書

• 研究課題/領域番号: 20590980
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 腎臓内科学
• 研究機関: 大阪市立大学
• 研究代表者: 稲葉 雅章 大阪市立大学, 大学院・医学研究科, 教授 (00176405)
• 研究分担者: 今西 康雄 大阪市立大学, 大学院・医学研究科, 講師 (50326253)
• 研究期間 (年度): 2008 – 2010
• キーワード: 人工透析学 / 副甲状腺アデノーマ / 2次性副甲状腺機能亢進症 / 副甲状腺ホルモン

研究概要

副甲状腺細胞は細胞膜上のカルシウム感知受容体(CaR)により細胞外カルシウム濃度に応じて副甲状腺ホルモン(PTH)の分泌量を調節し、PTHのN端断片化はその一つの機構である。副甲状腺細胞に細胞内カルシウムキレーターを添加するとPTH分泌抑制は解除されたが、N端断片化には変化を認めなかった。PTH分子N端断片化機構はPTH分泌抑制機構における細胞内シグナル伝達系とは異なることが示唆された。

研究成果

• [雑誌論文] Reduction of whole PTH/intact PTH ratio as a predictor of bone metabolism in cinacalcet treatment of hemodialysis patients with secondary hyperparathyroidism (2011)
  • 著者名/発表者名: Kurajoh M 総10名, Inaba M (2番目), Imanishi Y (6番目)
  • 雑誌名: Osteoporos Int 22 ページ: 923-930
  • 査読あり
• [雑誌論文] Association of serum TRAIL levels with atherosclerosis in patients with type 2 diabetes mellitus (2011)
  • 著者名/発表者名: Kawano N 総12名, Inaba M (12番目)
  • 雑誌名: Diabetes research and clinical practice 91 ページ: 316-320
  • 査読あり
• [雑誌論文] Different impacts of neck circumference and visceral obesity on the severity of obstructive sleep apnea syndrome (2011)
  • 著者名/発表者名: Kawaguchi Y, 総7名, Inaba M (3番目)
  • 雑誌名: Obesity 19 ページ: 276-282
  • 査読あり
• [雑誌論文] Advanced glycation end products, carotid atherosclerosis, and circulating endothelial progenitor cells in patients with end-stage renal disease (2011)
  • 著者名/発表者名: Ueno H, 総12名, Inaba M (8番目)
  • 雑誌名: Metabolism 60 ページ: 453-459
  • 査読あり
• [雑誌論文] Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy : evaluation of both HBsAg-positive and HBsAg-negative cohorts. (2011)
  • 著者名/発表者名: Tamori A, 総11名, Inaba M (8番目)
  • 雑誌名: Journal of gastroenterology 46 ページ: 556-564
  • 査読あり
• [雑誌論文] Increased osteocyte death and mineralization inside bone after parathyroidectomy in patients with secondary hyperparathyroidism (2010)
  • 著者名/発表者名: Yajima A, Inaba M, 他5名
  • 雑誌名: J Bone Miner Res 25 ページ: 2374-2381
  • 査読あり
• [雑誌論文] The administration of an active vitamin D3 analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type Ib patients (2010)
  • 著者名/発表者名: Ishii A 総8名, Imanishi Y (2番目), Inaba M (7番目)
  • 雑誌名: Endocr J 57 ページ: 609-614
  • 査読あり
• [雑誌論文] The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels (2010)
  • 著者名/発表者名: Ishii A 総19名, Imanishi Y (2番目), Inaba M (18番目)
  • 雑誌名: Calcif Tissue Int 86 ページ: 455-462
  • 査読あり
• [雑誌論文] Poor muscle quality rather than reduced lean body mass is responsible for the lower serum creatinine level in hemodialysis patients with diabetes mellitus (2010)
  • 著者名/発表者名: Inaba M, 総9名, Imanishi Y (4番目)
  • 雑誌名: Clin Nephrol 74 ページ: 266-272
  • 査読あり
• [雑誌論文] Decreases in parathyroid gland volume after cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism (2010)
  • 著者名/発表者名: Ichii M 総11名, Inaba M (10番目)
  • 雑誌名: Nephron Clin Pract 115 ページ: c195-c202
  • 査読あり
• [雑誌論文] Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus (2010)
  • 著者名/発表者名: Emoto M 総11名, Inaba M (10番目)
  • 雑誌名: Metabolism 59 ページ: 873-878
  • 査読あり
• [雑誌論文] Time-course of health status in patients with rheumatoid arthritis during the first year of treatment with infliximab (2010)
  • 著者名/発表者名: Ban A, Inaba M, 他5名
  • 雑誌名: Biomed Pharmacother 64 ページ: 107-112
  • 査読あり
• [雑誌論文] Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus (2010)
  • 著者名/発表者名: Yamada S, 総8名, Inaba M (2番目), Imanishi Y (4番目)
  • 雑誌名: Metabolism 59 ページ: 390-394
  • 査読あり
• [雑誌論文] Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse (2010)
  • 著者名/発表者名: Ueno H, 総14名, Inaba M (13番目)
  • 雑誌名: Atherosclerosis 211 ページ: 431-436
  • 査読あり
• [雑誌論文] Regions of arterial stenosis and clinical factors determining transcutaneous oxygen tension in patients with peripheral arterial disease (2010)
  • 著者名/発表者名: Ueno H, 総12名, Inaba M (11番目)
  • 雑誌名: J Atheroscler Thromb 17 ページ: 858-869
  • 査読あり
• [雑誌論文] Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate (2010)
  • 著者名/発表者名: Tsuchikura S, 総9名, Inaba M (8番目)
  • 雑誌名: BMC Nephrol 11 ページ: 7
  • 査読あり
• [雑誌論文] Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus (2010)
  • 著者名/発表者名: Tamori A, 総10名, Imanishi Y (9番目)
  • 雑誌名: J Viral Hepat 17 ページ: 123-129
  • 査読あり
• [雑誌論文] Effects of raloxifene treatment on the structural geometry of the proximal femur in Japanese women with osteoporosis (2010)
  • 著者名/発表者名: Takada J, Miki T, Imanishi Y, 他7名
  • 雑誌名: J Bone Miner Metab 28 ページ: 561-567
  • 査読あり
• [雑誌論文] Preferential reduction of bone mineral density at the femur reflects impairment of physical activity in patients with low-activity rheumatoid arthritis (2010)
  • 著者名/発表者名: Sugiguchi S, Goto H, Inaba M, Nishizawa Y
  • 雑誌名: Mod Rheumatol 20 ページ: 69-73
  • 査読あり
• [雑誌論文] Arterial stiffness predicts cardiovascular death independent of arterial thickness in a cohort of hemodialysis patients (2010)
  • 著者名/発表者名: Shoji T, 総8名, Inaba M (7番目)
  • 雑誌名: Atherosclerosis 210 ページ: 145-149
  • 査読あり
• [雑誌論文] Cerebral microbleeds in predialysis patients with chronic kidney disease (2010)
  • 著者名/発表者名: Shima H, 総13名, Inaba M (10番目)
  • 雑誌名: Nephrol Dial Transplant 25 ページ: 1554-1559
  • 査読あり
• [雑誌論文] Thyroid blood flow as a useful predictor of relapse of Graves' disease after normal delivery in patients with Graves' disease (2010)
  • 著者名/発表者名: Nagasaki T, Inaba M, 他8名
  • 雑誌名: Biomed Pharmacother 64 ページ: 113-117
  • 査読あり
• [雑誌論文] Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes (2010)
  • 著者名/発表者名: Mori K, 総11名, Inaba M (10番目)
  • 雑誌名: Angiology 61 ページ: 86-91
  • 査読あり
• [雑誌論文] Association of serum TRAIL level with coronary artery disease (2010)
  • 著者名/発表者名: Mori K, 総9名, Inaba M (7番目)
  • 雑誌名: Thromb Res 125 ページ: 322-325
  • 査読あり
• [雑誌論文] Fetuin-A is associated with calcified coronary artery disease (2010)
  • 著者名/発表者名: Mori K, 総11名, Inaba M (9番目)
  • 雑誌名: Coron Artery Dis 21 ページ: 281-285
  • 査読あり
• [雑誌論文] Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis (2010)
  • 著者名/発表者名: Koyama H, 総15名, Inaba M (4番目)
  • 雑誌名: Clin J Am Soc Nephrol 5 ページ: 659-666
  • 査読あり
• [雑誌論文] Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients (2010)
  • 著者名/発表者名: Kobayashi I, 総9名, Inaba M (8番目)
  • 雑誌名: Nephrol Dial Transplant 25 ページ: 3361-3365
  • 査読あり
• [雑誌論文] Advanced glycation end products, carotid atherosclerosis, and circulating endothelial progenitor cells in patients with end-stage renal disease (2010)
  • 著者名/発表者名: Ueno H 総12名, Inaba M (8番目)
  • 雑誌名: Metabolism 60 ページ: 453-459
• [雑誌論文] Beneficial effect of risedronate on arterial thickening and stiffening with a reciprocal relationship to its effect on bone mass in female osteoporosis patients : a longitudinal study (2010)
  • 著者名/発表者名: Okamoto K 総8名, Inaba M (2番目), Imanishi Y (7番目)
  • 雑誌名: Life sciences 87 ページ: 686-691
• [雑誌論文] Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease. (2010)
  • 著者名/発表者名: Mima Y 総11名, Inaba M (11番目)
  • 雑誌名: Osaka city medical journal 56 ページ: 27-36
• [雑誌論文] Poor glycemic control is a significant predictor of cardiovascular events in chronic hemodialysis patients with diabetes (2009)
  • 著者名/発表者名: Tsujimoto Y, 総11名, Inaba M (8番目)
  • 雑誌名: Ther Apher Dial 13 ページ: 358-365
  • 査読あり
• [雑誌論文] Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case (2009)
  • 著者名/発表者名: Onoda N, 総10名, Inaba M (5番目)
  • 雑誌名: Endocr J 56 ページ: 495-502
  • 査読あり
• [雑誌論文] Serum β_2-microglobulin level is a significant predictor of mortality in maintenance haemodialysis patients (2009)
  • 著者名/発表者名: Okuno S, 総8名, Inaba M (7番目)
  • 雑誌名: Nephrol Dial Transplant 24 ページ: 571-577
  • 査読あり
• [雑誌論文] Severe arterial hypertension : a possible complication of McCune-Albright syndrome (2009)
  • 著者名/発表者名: Ohata Y, 総9名, Imanishi Y (6番目)
  • 雑誌名: Eur J Pediatr 168 ページ: 871-876
  • 査読あり
• [雑誌論文] Glycated albumin as an improved indicator of glycemic control in hemodialysis patients with type 2 diabetes based on fasting plasma glucose and oral glucose tolerance test (2009)
  • 著者名/発表者名: Nagayama H, Inaba M, 他5名
  • 雑誌名: Biomed Pharmacother 63 ページ: 236-240
  • 査読あり
• [雑誌論文] Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of thyroid function : a double-blind, placebo-controlled study (2009)
  • 著者名/発表者名: Nagasaki T, Inaba M, 他8名
  • 雑誌名: Eur J Endocrinol 160 ページ: 409-415
  • 査読あり
• [雑誌論文] Significant association of fracture of the lumbar spine with mortality in female hemodialysis patients : a prospective observational study (2009)
  • 著者名/発表者名: Maeno Y, Inaba M, 他6名
  • 雑誌名: Calcif Tissue Int 85 ページ: 310-316
  • 査読あり
• [雑誌論文] The combination of IMT and stiffness parameter beta is highly associated with concurrent coronary artery disease in type 2 diabetes (2009)
  • 著者名/発表者名: Lee E, 総13名, Inaba M (12番目)
  • 雑誌名: J Atheroscler Thromb 16 ページ: 33-39
  • 査読あり
• [雑誌論文] Association of reduction in bone mineral density with mortality in male hemodialysis patients (2009)
  • 著者名/発表者名: Kohno K, Inaba M, 他6名
  • 雑誌名: Calcif Tissue Int 84 ページ: 180-185
  • 査読あり
• [雑誌論文] Renal biopsy in a patient with haemophilia A and cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection (2009)
  • 著者名/発表者名: Kobayashi I, 総11名, Inaba M (9番目)
  • 雑誌名: NDT Plus 2 ページ: 373-375
  • 査読あり
• [雑誌論文] Osteosarcoma in a pregnant patient with McCune-Albright syndrome (2009)
  • 著者名/発表者名: Kanazawa I, 総12名, Imanishi Y (4番目), Inaba M (9番目)
  • 雑誌名: Bone 45 ページ: 603-608
  • 査読あり
• [雑誌論文] Glycemic control and survival of diabetic hemodialysis patients-importance of lower hemoglobin A1C levels (2009)
  • 著者名/発表者名: Ishimura E, 総12名, Inaba M (11番目)
  • 雑誌名: Diabetes Res Clin Pract 83 ページ: 320-326
  • 査読あり
• [雑誌論文] Cinacalcet in hyperfunctioning parathyroid diseases (2009)
  • 著者名/発表者名: Imanishi Y, Inaba M, 他2名
  • 雑誌名: Ther Apher Dial 13 Suppl 1 ページ: S7-S11
  • 査読あり
• [雑誌論文] Animal models of hyperfunctioning parathyroid diseases for drug development (2009)
  • 著者名/発表者名: Imanishi Y, Inaba M, 他2名
  • 雑誌名: Expert Opin Drug Discov 4 ページ: 727-740
  • 査読あり
• [雑誌論文] Severe hypophosphatemic osteomalacia with fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis (2009)
  • 著者名/発表者名: Bando H, 総9名, Imanishi Y (7番目)
  • 雑誌名: Intern Med 48 ページ: 353-358
  • 査読あり
• [雑誌論文] Association of glycated albumin, but not glycated hemoglobin, with peripheral vascular calcification in hemodialysis patients with type 2 diabetes (2008)
  • 著者名/発表者名: Yamada S, Inaba M, 他5名
  • 雑誌名: Life Sci 83 ページ: 516-519
  • 査読あり
• [雑誌論文] Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease : independence from renal dysfunction (2008)
  • 著者名/発表者名: Yamada S, 総7名, Inaba M (2番目), Imanishi Y (5番目)
  • 雑誌名: Clin Endocrinol (Oxf) 69 ページ: 189-196
  • 査読あり
• [雑誌論文] Bone formation by minimodeling is more active than remodeling after parathyroidectomy (2008)
  • 著者名/発表者名: Yajima A, Inaba M, 他2名
  • 雑誌名: Kidney Int 74 ページ: 775-781
  • 査読あり
• [雑誌論文] Serum Levels of TRAP5b, a New Bone Resorption Marker Unaffected by Renal Dysfunction, as a Useful Marker of Cortical Bone Loss in Hemodialysis Patients (2008)
  • 著者名/発表者名: Shidara K, Inaba M, 他7名
  • 雑誌名: Calcif Tissue Int 82 ページ: 278-287
  • 査読あり
• [雑誌論文] Clinical and Biochemical Response of TNFRSF11A-Mediated Early-Onset Familial Paget Disease to Bisphosphonate Therapy (2008)
  • 著者名/発表者名: Riches PL, Imanishi Y, 他2名
  • 雑誌名: Calcif Tissue Int 83 ページ: 272-275
  • 査読あり
• [雑誌論文] Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects (2008)
  • 著者名/発表者名: Nishizawa Y, Inaba M, 他8名
  • 雑誌名: J Bone Miner Metab 26 ページ: 265-270
  • 査読あり
• [雑誌論文] Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus (2008)
  • 著者名/発表者名: Mori K, 総10名, Inaba M (9番目)
  • 雑誌名: Metabolism 57 ページ: 1248-1252
  • 査読あり
• [雑誌論文] Influence of atherosclerosis on the relationship between anaemia and mortality risk in haemodialysis patients (2008)
  • 著者名/発表者名: Maekawa K, 総8名, Inaba M (7番目)
  • 雑誌名: Nephrol Dial Transplant 23 ページ: 2329-2336
  • 査読あり
• [雑誌論文] Association of increased active PTH(1-84) fraction with decreased GFR and serum Ca in predialysis CRF patients : modulation by serum 25-OH-D (2008)
  • 著者名/発表者名: Kurajoh M, Inaba M, Yamada S, Imanishi Y, 他3名
  • 雑誌名: Osteoporos Int 19 ページ: 709-716
  • 査読あり
• [雑誌論文] Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes (2008)
  • 著者名/発表者名: Kumeda Y, Inaba M, 他6名
  • 雑誌名: Clin Endocrinol (Oxf) 69 ページ: 556-561
  • 査読あり
• [雑誌論文] Different risk factors for vascular calcification in end-stage renal disease between diabetics and nondiabetics : the respective importance of glycemic and phosphate control (2008)
  • 著者名/発表者名: Ishimura E, 総10名, Inaba M (9番目)
  • 雑誌名: Kidney Blood Press Res 31 ページ: 10-15
  • 査読あり
• [雑誌論文] Increased basal phosphorylation of mitogen-activated protein kinases and reduced responsiveness to inflammatory cytokines in neutrophils from patients with rheumatoid arthritis (2008)
  • 著者名/発表者名: Inaba M, 他8名
  • 雑誌名: Clin Exp Rheumatol 26 ページ: 52-60
  • 査読あり
• [学会発表] Coexpressions of FGF-23 and MEPE in causative tumors of oncogenic osteomalacia (2010)
  • 著者名/発表者名: Nagata Y
  • 学会等名: ASBMR 32nd Annual Meeting
  • 発表場所: Metro Toronto Convention Center
  • 年月日: 2010-10-16
• [学会発表] Reduction of Whole PTH/Intact PTH Ratio is a Predictor of Bone Metabolism by Cinacalcet Treatment in Hemodialysis Patients with Secondary Hyperparathyroidism (2010)
  • 著者名/発表者名: Kurajoh M
  • 学会等名: ASBMR 32nd Annual Meeting
  • 発表場所: Metro Toronto Convention Center
  • 年月日: 2010-10-16
• [学会発表] Suppression of Circulating Fibroblast Growth Factor-23 by Cinacalcet in Patients with Primary Hyperparathyroidism (2010)
  • 著者名/発表者名: Imanishi Y
  • 学会等名: 12th European Congress of Endocrinology
  • 発表場所: Prague Congress Centre
  • 年月日: 2010-04-27
• [学会発表] Octreotide therapies were unable to improve hypophosphatemia in oncogenic osteomalacia (2010)
  • 著者名/発表者名: Ishii A
  • 学会等名: 14th International Congress of Endocrinology (ICE2010)
  • 発表場所: Kyoto International Conference Center
  • 年月日: 2010-03-28
• [学会発表] Regulation of Circulating Fibroblast Growth Factor-23 by parathyroid hormone in Patients with Primary Hyperparathyroidism (2010)
  • 著者名/発表者名: Kurajoh M
  • 学会等名: 14th International Congress of Endocrinology (ICE2010)
  • 発表場所: Kyoto International Conference Center
  • 年月日: 2010-03-28
• [学会発表] Expressions of Somatostatin Receptors on Responsible Tumors are Insufficient for Their Agonist to Normalize Serum Phosphate Levels in Oncogenic Osteomalacia (2009)
  • 著者名/発表者名: Ishii A
  • 学会等名: ASBMR 31th Annual Meeting
  • 発表場所: Colorado Convention Center
  • 年月日: 2009-09-14
• [学会発表] Cinacalcet Suppresses Circulating Fibroblast Growth Factor-23 in Patients with Primary Hyperparathyroidism (2009)
  • 著者名/発表者名: Kurajoh M
  • 学会等名: ASBMR 31th Annual Meeting
  • 発表場所: Colorado Convention Center
  • 年月日: 2009-09-13
• [学会発表] Activation of Calcium-Sensing Receptor Accelerates Amino-terminal Truncation of Human Parathyroid Hormone (1-84) in the Patients with Primary Hyperparathyroidism (2009)
  • 著者名/発表者名: Imanishi Y
  • 学会等名: ASBMR 31th Annual Meeting
  • 発表場所: Colorado Convention Center
  • 年月日: 2009-09-12